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教授

马文建,博士,教授,博导。山东大学学士,中科院生物物理所硕士,德国科隆大学(University of Cologne)博士,美国NIH环境健康研究所(NIEHS)博士后。天津转基因生物安全指导委员会执法专家;天津生物医学工程学会,美国微生物学会(ASM),细胞生物学会(ASCB) 等会员;德国斯普林格(Springer)国际出版公司《癌症百科全书》辞条编写成员;任Cancer Letters, Genetics, Toxicology & Applied Pharmacology, Toxicology Letters, Journal of Molecular Biology, Mutation Research, Journal of Photochemistry & Photobiology, Biochemical Journal等国际期刊审稿人。

主讲课程
本科生:细胞生物学(英文)
研究生:新药研究与开发;科技论文写作等

科研领域及方向
[1] DNA损伤修复/基因组稳定性机制
[2] 肿瘤、衰老的分子生物学及药理学研究
[3] 食品/药品安全检测及体系构建

科研项目情况
[1] 国家重点研发项目“益生菌健康功能与基于肠道微生物组学的食品营养代谢机理研究”(2017-2020,2314万),子课题负责人
[2] 天津市131创新型人才团队“天津科技大学微生态调控与分子药理学团队”(2018-2020,120万), 骨干成员
[3] 天津市高等学校创新团队“基于肠道微生态调控的食品营养功能和安全评价”(2018-2020,180万),骨干成员
[4] 天津市特聘教授科研启动基金 (2015-2019,100万),项目负责人
[5] 天津市优秀人才基金(2015,30万),项目负责人
[6] 国家自然科学基金“聚集型DNA损伤在不同细胞周期中的修复及抑癌机制研究”(2012-2015,60万),项目负责人
[7] 天津市科委基金“MRTF-A激活CYP1A1转录调控类固醇激素代谢”(2011-2014,10万),项目负责人

主要学术成果
在PNAS(影响因子9.6)和Nucleic Acids Research(影响因子10.2)等高水平SCI期刊上发表科研论文/专著40余篇,引用2000余次。2012年应国际著名的Springer出版公司邀请,担任癌症百科全书两个辞条的撰写人。
近年代表性学术论文:
[1].Liu Q., Zhang Z., Liu Y., Cui Z., Zhang T., Li Z., Ma W. Cancer cells growing on perfused 3D collagen model produced higher ROS level and were more resistant to cisplatin comparing to 2D model. J Appl Biomater Funct Mater. 2018 Jul;16(3):144-150. 
[2].Zhang R., Li H., Zhang S., Zhang Y., Wang N., Zhou H., He H., Hu G., Zhang T., Ma W. RXRα provokes tumor suppression through p53/p21/p16 and PI3K-AKT signaling pathways during stem cell differentiation and in cancer cells. Cell Death &Disease, 2018 May 10;9(5):532.
[3].He H, Du F, He Y, Wei Z, Meng C, Xu Y, Zhou H, Wang N, Luo XG, Ma W, Zhang TC. The Wnt-β-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells. Oncotarget. 2018 Jan 4;9(20):15239-15251.
[4].He H, Lai Y, Hao Y, Liu Y, Zhang Z, Liu X, Guo C, Zhang M, Zhou H, Wang N, Luo XG, Huo L, Ma W, Zhang TC. Selective p300 inhibitor C646 inhibited HPV E6-E7 genes, altered glucose metabolism and induced apoptosis in cervical cancer cells. Eur J Pharmacol. 2017 Oct 5;812:206-215.
[5].Wang C, Li Z, Wang H, Qiu H, Zhang M, Li S, Luo X, Song Y, Zhou H, Ma W, Zhang T., Rapid biodegradation of aflatoxin B1 by metabolites of Fusarium sp. WCQ3361 with broad working temperature range and excellent thermostability. J Sci Food Agric,2017 Mar 1;97(4):1342~1348
[6].He H, Wei Z, Du F, Meng C, Zheng D, Lai Y, Yao H, Zhou H, Wang N, Luo XG, Ma W, Zhang TC., Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells.,Cellular Signalling,2017 Feb 1;31:87~95
[7].Zhang R, Wang N, Zhang LN, Huang N, Song TF, Li ZZ, Li M, Luo XG, Zhou H, He HP, Zhang XY, Ma W, Zhang TC,Knockdown of DNMT1 and DNMT3a Promotes the Angiogenesis of Human Mesenchymal Stem Cells Leading to Arterial Specific Differentiation., Stem Cells,2016 May ;34(5):1273~1283
[8].Liao XH, Zheng L, He HP, Zheng DL, Wei ZQ, Wang N, Dong J, Ma W, Zhang TC. STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells. Cell Signal. 2015 Nov;27(11):2285-95.
[9].Ma W, Westmoreland JW, and Resnick MA. Homologous recombination rescues ssDNA gaps generated by NER and reduced translesion DNA synthesis in G2 cells. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2895-904.
[10].Covo S, Ma W, Westmoreland JW, Gordenin DA and Resnick MA. Understanding the origins of UV-induced recombination through manipulation of sister chromatid cohesion. Cell Cycle. 2012Nov;11(21) 3937-44
[11].Ma W, Halweg CJ, Menendez D, Resnick MA. Differential effects of PARP inhibition and depletion on single- and double-strand break repair in human cells are revealed with EBV. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5.
[12].Ma W, Westmoreland JW, Gordenin DA and Resnick MA. Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease. PLoS Genetics, 2011 7(4): e1002059
[13].Westmoreland JW, Ma W, Yan Y, Van Hulle K, Malkova A, and Resnick MA. RAD50 (RMX) is essential for efficient resection and recombinational repair of radiation-induced double-strand breaks but not crossovers. PLoS Genetics, 2009 Sep;5(9):e1000656
[14].Ma W, Panduri V, Sterling J, Van Houten B, Gordenin DA, Resnick MA. The transition of closely-spaced lesions into double-strand breaks is prevented by an interaction between Pol32, Rad27/FEN1 and PCNA. Mol. Cell Biol. 2009 Mar;29(5):1212-21
[15].Ma W, Resnick MA and Gordenin DA  Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic Acids Research. 2008 Apr;36(6):1836-46
专著章节
[16].Ma W (2012) Topoisomerases. Encyclopedia of Cancer, Edited by Dr. Manfred Schwab; New York: Springer, http://www.springerreference.com/docs/html/chapterdbid/177517.html
[17].Ma W (2012) Cell cycle checkpoints. Encyclopedia of Cancer, Edited by Dr. Manfred Schwab; New York: Springer, http://www.springerreference.com/docs/html/chapterdbid/172653.html
[18].Ma W, Westmoreland JW and Resnick MA. (2011) Characterizing resection at random and unique chromosome double-strand breaks and telomere ends. Methods in Molecular Biology. Vol. 745: 15-31

联系方式:
办公地点:天津经济技术开发区第十三大街29号天津科技大学生物工程院,300457。

办公电话:022-60602831;

传真:022-60602831;

Email: ma_wj@tust.edu.cn。

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