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王楠,博士,yh1187银河网站教授。“天津市131创新型人才培养工程第一层次”人选,天津市“131“创新型人才团队负责人,天津市高校第一批“优秀青年教师资助计划”,天津青年“创新创业创优”先进个人荣誉称号。中国细胞生物学学会会员,中国生物化学学会会员,中国细胞生物学学会干细胞分会会员。目前是《Stem Cells》、《Experiment Cell Research》、《Journal of Cellular and Molecular Medicine》、《Gene》等多个SCI期刊的同行评议人。
目前主要从事心血管疾病及干细胞分化中的转录调控及表观遗传学修饰等研究工作,同时开展益生菌与功能因子在机体发育、肠道疾病调节等方面的调控作用及作用机制。主持省部级以上科研项目8项,参与多项国家级及省部级项目,共发表论文80余篇,其中以第一或通讯作者发表SCI论文20余篇。 

主讲课程:
本科生:《细胞生物学》、《生物制药概论》、《制药工程专题前沿进展》
研究生:《分子药理学》

主要教学研究及成果情况
先后参与教改项目1项,获得校级教学成果奖1项,发表教改论文3篇,参编教材1部。
[1] 天津科技大学教育教学改革规划课题:制药工程专业药理学双语教学新体系的建立,2012-2014。第五参与人。
[2] 罗学刚, 张同存, 王楠, 孙华, 滕玉鸥, 何红鹏。制药工程专业药理学双语教学新体系的构建与实践. 天津科技大学校。教学成果奖一等奖。2018年3月。
[3] N Wang,M Li,TC Zhang,XG Luo。Discussion on the Teaching Methods of Pharmaceutical Engineering Education。Creative Education,2013,3 (7B):80-82。
[4] 王巨克,罗学刚,王楠,戴炳业,张同存。依托高校省部级重点实验室培养本科生科研能力。中国轻工教育,2012,04:66-68。
[5] 罗学刚,张同存,王楠,姜勇。药物制剂工程课堂教学体会。药学教育,2008,24(4):24-25。
[6] 《药理学(双语)》,华中科技大学出版社,2013年8月。

科研领域及方向
[1]表观遗传学修饰调控血管生成与重构
[2]lncRNA调控平滑肌表型转化与动脉硬化
[3]益生菌及功能因子对机体发育和肠道疾病的调控

科研项目情况:
1.天津市131创新型人才团队带头人,“天津科技大学微生态调控与分子药理学团队”,201801-202012,120万。
2.天津市高等学校创新团队负责人,“基于肠道微生态调控的食品营养功能和安全评价”,“TD13-5015”,201801-202012,180万。
3.“益生菌健康功能与基于肠道微生物组学的食品营养代谢机理研究”课题四子课题“益生菌及肠道微生物对人体细胞分化和发育的影响机制研究”(2017YFD0400304)。国家重点研发计划2017/01-2020/12,2314万,子课题110万,子课题负责人。
4.DNA去甲基化特异性调控动脉内皮细胞分化和血管生成(17JCZDJC33600)。天津市自然科学基金,201704-202004,20万,项目负责人。
5.MRTF-A调控CYR61介导间充质干细胞向内皮细胞分化的分子机制研究(31171303)。国家自然科学基金面上项目,2012-2015,60万,项目负责人。  
6.MRTF参与调控间充质干细胞向胰岛素分泌细胞分化的研究(212010)。教育部科技研究重点项目,2012-2014,5万,项目负责人。 
7.TGF-β激活Myocardin家族诱导骨髓间充质干细胞分化的研究(30800561)。国家自然科学基金青年基金,2009-2011,20万,项目负责人。
8.骨髓间充质干细胞向平滑肌细胞定向分化的分子调控研究(09JCZDJC18100)。天津市应用基础及前沿技术研究计划重点项目,2009-2011,20万,项目负责人。
9.Myocardin调节骨髓间充质干细胞分化的研究(20080409)。天津科技大学人才引进基金,2008-2010,项目负责人。
10.天然多糖的制备与功能多糖的研制(2012AA021505)。国家863项目,2012-2015,58万,第三参与人。
11.食品微生物基因组改造(2012AA022108)。国家高技术研究发展计划(863),201211-201512,210万,参与。
12.MRTF-A促进雌激素代谢及机制研究(20111208110001)。高等学校博士学科点专项科研基金联合资助课题,2012-2014,12万。第三参与人。
13.Myocardin和SRC-1相互作用及在药物代谢中的功能(07JCYBJC16400)。天津市自然科学基金项目,2007-2010,8万。第三参与人。
14.益生菌定向筛选与功能开发关键技术的研究(2008AA10Z336)。国家863计划,2007-2010,110万。第六参与人。
15.膜整连蛋白介导的神经干细胞增殖、分化信号转导(30470404)。国家自然科学基金。2005-2007。第三参与人。

主要学术成果(论文,专著,专利及授权情况)
先后发表各类科研论文80余篇,其中以第一或通讯作者发表SCI论文20余篇,授权或申请发明专利6项。发表的主要学术论文有:
1.Kuramoto K#, Wang N#, Fan Y, Zhang W, Schoenen FJ, Frankowski KJ, Marugan J, Zhou Y, Huang S, He C*. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 2016 Sep;12(9):1460-71. (# Co-first author) (SCI, 1区, IF=9.108)
2.Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, He C. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 2016 Oct 28:141-56. (SCI, 1区, IF=9.108)
3.Zhang R#, Wang N#*, Zhang LN, Huang N, Song TF, Li ZZ, Li M, Luo XG, Zhou H, He HP, Zhang XY, Ma W, Zhang TC*. Knockdown of Dnmt1 and Dnmt3a Promotes the Angiogenesis of hMSCs Leading to Arterial Specific Differentiation. Stem Cells. 2016 May;34(5):1273-83. (SCI, 1区, IF= 5.902)
4.Liao XH#, Wang N#, Zhao DW, Zheng DL, Zheng L, Xing WJ, Ma WJ, Bao LY, Dong J, Zhang TC*. STAT3 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin. J Biol Chem. 2015 Aug 7;290(32):19641-52. (SCI, 2区, IF= 4.258)
5.Zhuang C, Yuan Y, Song T, Wang H, Huang L, Luo X, He H, Huo L, Zhou H, Wang N*, Zhang T*. miR-219a-5p inhibits breast cancer cell migration and epithelial-mesenchymal transition by targeting myocardin-related transcription factor A. Acta Biochim Biophys Sin (Shanghai). 2017 Oct 25:1-10. 
6.Mao L, Wang H, Ma F, Guo Z, He H, Zhou H, Wang N*. Exposure to static magnetic fields increases insulin secretion in rat INS-1 cells by activating the transcription of the insulin gene and up-regulating the expression of vesicle-secreted proteins. Int J Radiat Biol. 2017 Aug;93(8):831-840. 
7.Xing-Hua Liao#, Nan Wang#*, Dong-Wei Zhao, De-Liang Zheng, Li Zheng, Wen-Jing Xing, Hao Zhou, Dong-Sun Cao, Tong-Cun Zhang*. NF-κB (p65) negatively regulates myocardin-induced cardiomyocyte hypertrophy through multiple mechanisms. Cellular Signalling. 2014 Dec;26(12):2738-48.. (# Co-first author) (*, corresponding author) (SCI, 2区, IF=4.132) 
8.Xing-Hua Liao#, Yan-Qi Li#, Nan Wang#,*, Li Zheng, Wen-Jing Xing, Dong-Wei Zhao, Ting-Bao Yan, Yue Wang, Long-Yue Liu, Xue-Guang Sun, Peng Hu, Hao Zhou, Tong-Cun Zhang*. Re-expression and epigenetic modification of maspin induced apoptosis in MCF-7 cells mediated by myocardin. Cellular Signalling. 2014 Mar 6;26(6):1335-1346. (# Co-first author) (*, corresponding author) (SCI, 2区;IF=4.132) 
9.Li M#, Wang N#*, Zhang J, He HP, Gong HQ, Zhang R, Song TF, Zhang LN, Guo ZX, Cao DS, Zhang TC*. MicroRNA-29a-3p attenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytes. Gene. 2016 Jul 1;585(1):44-50. (SCI, 3区;IF=2.319) 
10.Li M, He HP, Gong HQ, Zhang J, Ma WJ, Zhou H, Cao DS, Wang N*, Zhang TC*. NFATc4 and myocardin synergistically up-regulate the expression of LTCC α1C in ET-1-induced cardiomyocyte hypertrophy. Life Sci. 2016 Jun 15;155:11-20. (SCI, 3区;IF=2.685)
11.Zhang R#, Wang N#*, Zhang M , Zhang LN, Guo ZX, Luo XG, Zhou H, He HP, Zhang TC*. Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells. Stem Cells Int. 2015; 2015:534758. (SCI, 3区;IF= 3.687)
12.Li W#, Wang N#*, Li M, Gong H, Liao X, Yang X, Zhang T*. Protein kinase Cα inhibits myocardin-induced cardiomyocyte hypertrophy through the promotion of myocardin phosphorylation. Acta Biochim Biophys Sin (Shanghai). 2015 Sep;47(9):687-95. 
13.Xing WJ#, Liao XH#, Wang N#*, Zhao DW, Zheng L, Zheng L, Dong J, Zhang TC*. MRTF-A and STAT3 promote MDA-MB-231 cell migration via hypermethylating BRSM1. IUBMB Life. 2015 Mar;67(3):202-17. (SCI, 3区;IF= 2.653)
14.Shu XZ, Zhang LN, Zhang R, Zhang CJ, He HP, Zhou H, Wang N*, Zhang TC*. Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells. Gene. 2015 Mar 5.563, 17-23. (SCI, 3区;IF= 2.319)
15.Jian RL, Mao LB, Xu Y, Li XF, Wang FP, Luo XG, Zhou H, He HP, Wang N*, Zhang TC*. Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells. Gene 2015 May 10;562(1):107-16. (SCI, 3区;IF= 2.319)
16.Man Li#, Nan Wang#*, Hui-Qin Gong, Wei-Zong Li, Xing-Hua Liao, Xiao-Long Yang, Hong-Peng He, Dong-Sun Cao, Tong-Cun Zhang*. Ca2+ signals induced cardiomyocyte hypertrophy through activation of myocardin. Gene. 2015 Feb 15;557(1):43-51..(# Co-first author) (*, corresponding author) (SCI, 3区;IF= 2.319)
17.Xing-Hua Liao#, Nan Wang#*, Long-Yue Liu, Li Zheng, Wen-Jing Xing, Dong-Wei Zhao, Xue-Guang Sun, Peng Hu, Jian Dong, Tong-Cun Zhang*. MRTF-A and STAT3 synergistically promote breast cancer cell migration. Cellular Signalling. 2014 Nov;26(11):2370-80. (# Co-first author) (*, corresponding author) (SCI, 2区)
18.Liao XH#, Wang Y#, Wang N#,*, Yan TB, Xing WJ, Zheng L, Zhao DW, Li YQ, Liu LY, Sun XG, Hu P, Zhang TC*. Human chorionic gonadotropin decreases human breast cancer cell proliferation and promotes differentiation. IUBMB Life. 2014 May;66(5):352-60. (# Co-first author) (*, corresponding author) (SCI, 3区)
19.Xing-Hua Liao#, Da-Lin Lu#, Nan Wang#, Long-Yue Liu, Yue Wang, Yan-Qi Li, Ting-Bao Yan, Xue–Guang Sun, Peng Hu and Tong-Cun Zhang*. Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway. FEBS J. 2014 Feb;281(3):927-42. . (# Co-first author) (*, corresponding author)  (SCI,3区;IF=4.001)
20.Nan Wang, Rui Zhang, Shui-Jing Wang, Chun-Ling Zhang, Li-Bin Mao,Chun-Yu Zhuang, Yan-Yang Tang, Xue-Gang Luo, Hao Zhou, Tong-Cun Zhang*.Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription actor-A signaling pathway. The International Journal of Biochemistry & Cell Biology. 2013 Jul;45(7):1447-56 (SCI, 2区;收录号175KH;IF=4.125)
21.Nan Wang, Yao Xu, Tao Qin, Feng-Po Wang, Lin-Lin Ma, Xue-Gang Luo, Tong-Cun Zhang*. Myocardin-related transcription factor-A is a key regulator in retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells. Gene.523 (2013): 178-186. (SCI, 3区;收录号164QK;IF=2.196)
22.Lin F, Wang N*, Zhang TC*. The role of endothelial-mesenchymal transition in development and pathological process. IUBMB Life. 2012 Sep;64(9):717-23. (* Corresponding author) (SCI, 3区;收录号993VA;IF=2.789)
23.Nan Wang, Guang-Da Ren, Zhen Zhou, Yao Xu, Tao Qin, Ru-Fa Yu, Tong-Cun Zhang*. Cooperation of myocardin and smad2 in inducing differentiation of mesenchymal stem cells into smooth muscle cells. IUBMB Life. 2012 Apr;64(4):331-9. (SCI, 3区;收录号907OK;IF=2.789)
24.Liao Xing-Hua#, Nan Wang#, Qing-Xi Liu, Tao Qin, Bo Cao, Dong-Sun Cao, Tong-Cun Zhang*. Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy. IUBMB Life. 2011; 1, 63(1): 54-61. (* Co-first author) (SCI, 3区;收录号725WH;IF 2011 = 3.514) 
25.Nan Wang, Zhen Zhou, Xinghua Liao and Tongcun Zhang*,Role of microRNAs in cardiac hypertrophy and heart failure. IUBMB Life, 2009 Jun;61(6):566-71. (SCI,3区;收录号454IU;IF= 3.578)
26.Wang N, Sun C, Huo S, Zhang Y, Zhao J, Zhang S, Miao J. Cooperation of phosphatidylcholine-specific phospholipase C and basic fibroblast growth factor in the neural differentiation of mesenchymal stem cells in vitro. Int J Biochem Cell Biol. 2008; 40(2):294-306. (SCI, 2区, IF= 4.178)  
27.Wang N, Xie K, Huo S, Zhao J, Zhang S, Miao J. Suppressing Phosphatidylcholine-specific Phospholipase C and elevating ROS level, NADPH oxidase activity and Rb level induced neuronal differentiation in mesenchymal stem cells. J Cell Biochem. 2007 Apr 15;100(6):1548-57. (SCI, 3区, IF= 3.54)
28.Wang N, Lv X, Su L, Zhao B, Zhang S, Miao J. D609 blocks cell survival and induces apoptosis in neural stem cells. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4780-3. (SCI, 3区, IF= 2.531) 
29.Wang N, Du CQ, Wang SS, Xie K, Zhang SL, Miao JY. D609 induces vascular endothelial cells and marrow stromal cells differentiation into neuron-like cells. Acta Pharmacol Sin. 2004 Apr;25(4):442-6. (IF= 1.676)

获奖情况:
2011年指导本科生参加"挑战杯"课外学术科技作品竞赛,获得“天津市一等奖”,获得"优秀指导教师"称号;2013年指导本科生参加"挑战杯"课外学术科技作品竞赛,获得“天津市三等奖”;2013年校级“先进个人”;2013年“师生一帮一助学活动中先进个人”;2015年天津青年“创新创业创优”先进个人荣誉称号。
 
联系方式
办公地点:天津经济技术开发区第十三大街29号yh1187银河网站(300457)
办公电话:022-60602099;传真:022-60602298;Email: wn929@tust.edu.cn



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