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教授


郁彭,博士,yh1187银河网站副院长,教授,博士生导师。法国国家药学科学院外籍通讯院士。《欧洲药物化学杂志》(European Journal of Medicinal Chemistry)副主编(1区Top)。天津市特聘专家,天津市特聘教授。科技部“食品营养与安全和药物化学国家国际科技合作基地”主任。
1999年获美国威斯康辛大学(密尔沃基)博士学位,同年进入美国Decode基因化学公司从事新药研发工作。期间主持了多项创新药物研发,完成了两个Ⅱ期临床药物的核心结构的创新性设计和实验室合成,作为共同发明人获得了5项美国专利和20多项其他各国专利保护。2009年9月回国受聘于yh1187银河网站,先后承担科技部,国家自然科学基金,天津市科委及企业委托项目若干。


主讲课程:
本科生:《药物合成反应实验》
研究生:《新药研究与开发》,《制药工程专题讲座》,《科技论文写作》


科研领域及方向:
主要研究方向有药物化学(小分子抑制剂,激活剂等)、抗肿瘤药理学、糖化学生物学、药物作用机制研究、新型递药系统、天然产物全合成、药物新制剂新剂型研究、天然活性物质的功效评价及其在保健品和化妆品中的应用等。


主要学术成果:回国后先后发表SCI论文近百篇,共申请专利80余项,美国授权发明专利1项,中国授权发明专利16项。


代表性学术论文:
(1)Yunsong Chang#, Yuan Yuan#, Qian Zhang, Yao Rong, Yang Yang, Ming Chi, Zhen Liu, Yongmin Zhang*, Peng Yu *, Yuou Teng*.Effects of an isatin derivative on tumor cell migration and angiogenesis. RSC Advances. 2020, 10, 1191-1197.
(2)Yongmin Zhang*, Peng Yu* and Yuou Teng*.Antioxidant Activities of Anastatins A&B derivatives and compound 38c protective effect in a mouse model of CCl4-induced acute liver injury. RSC Advances. 2020, 10, 14337-1346.
(3)Yuou Teng, Kui Lu, Qian Zhang, Lianbo Zhao, Yuna Huang, Angela Maria Ingarra,Herv e Galons, Tingshen Li, Shanshan Cui, Peng Yu *, Nassima Oumata *. Recent advances in the development of cyclin-dependent kinase 7 inhibitors.European Journal of Medicinal Chemistry.2019,183:111641-111650.
(4)Dong Wang,* Zhentao Wang, Zhenlin Liu, Mindong Huang, Jianyong Hu, and Peng Yu*.Strategic C-C bond-forming dearomatization of pyridines and quinolones.Organic Letters,2019,21:4459-4463.
(5)Mingyuan Li, Chunyang Du, Na Guo, Yuou Teng, Xin Meng, Hua Sun, Shuangshuang Li, Peng Yu*, Herve Galons*.Composition design and medical application of liposomes.European Journal of Medicinal Chemistry.2019, 164:640-653.
(6)Yu Wang , Chunyan Dou, Guidong He, Litong Ban, Liang Huang, Zheng Li,*,Jixian Gong, Jianfei Zhang and Peng Yu*. Biomedical Potential of Ultrafine Ag Nanoparticles Coated on Poly (Gamma-Glutamic Acid) Hydrogel with Special Reference to Wound Healing.Nanomaterials.2018, 8, 324-335.
(7)Qian Zhang, Yuou Teng, Yuan Yuan, Tingting Ruan, Qi Wang, Xing Gao, Yao Zhou,Kailin Han, Peng Yu*, Kui Lu**,Synthesis and cytotoxic studies of novel 5-phenylisatin derivatives and their anti-migration and anti-angiogenic evaluation.European Journal of Medicinal Chemistry.2018,156, 800-814.
(8)Dong Wang,* Zhenlin Liu, Zhentao Wang,Xinyue Maa and Peng Yu*.Metal- and base-free regioselective thiolation of the methyl C(sp3)–H bond in 2-picoline N-oxides.Green Chemistry.2019,21:157-163.
(9)Hua Sun, Xiaotong Song, Yunchang Tao, Ming Li, Ke Yang, Hang Zheng, Zongxin Jin, Robert H Dodd, Guojun Pan, Kui Lu*, & Peng Yu*. Synthesis & α-glucosidase inhibitory & glucose consumption-promoting activities of flavonoid–coumarin hybrids.Future Medicinal Chemistry.2018, 10(9):1055-1066.
(10)Dong Wang, Hairong Feng, Linna Li, Zhenlin Liu, Zhongli Yan, Peng Yu*.Access to 8‑Azachromones via Activation of C−H in N‑Oxides.Journal Of Organic Chemis.2017, 82:11275−11287.
(11)Cen Xiang, Yuou Teng, Chaoran Yao,Xuehui Li, Menglin Cao, Xuzhe Li,Guojun Pan, Kui Lu, Herv´e Galons* and Peng Yu*.Antioxidant properties of flavonoid derivatives and their hepatoprotective effects on CCl4 induced acute liver injury in mice.RSC Advances.2018, 8:15366-15371.
(12)Yang Yang, Haojie He, Hao Chang, Yao Yu, Meibing Yang, Yun He, Zhenchuan Fan, Suri S. Iyer, Peng Yu*.Multivalent oleanolic acid human serum albumin conjugate as nonglycosylated neomucin for influenza virus capture and entry inhibition.European Journal of Medicinal Chemistry.2018, 143: 1723-1731.
(13)Xin Meng, Chuanming Ji, Chao Su, Di Shen, Yaxin Li, Peijie Dong, Ding Yuan, Mengya Yang, Song Bai, Demei Meng, Zhenchuan Fan, Yang Yang*, Peng Yu*, Tao Zhu*.Synthesis and immunogenicity of PG-tb1 monovalent glycoconjugate,European Journal of Medicinal Chemistry.2017, 134: 140-146.
(14)Yuou Teng, Lixin Wang, Huan Liu, Yuan Yuan, Qian Zhang, Meng Wu, Luyao Wang, Haomeng Wang, Zhen Liu*, Peng Yu*.3'-Geranyl-mono-substituted chalcone Xanthoangelovl induces apoptosis in human leukemia K562 cells via activation of mitochondrial pathway.Chemico-Biological Interactions. 2017 261:103-107.
(15)Xin Meng,*, Meibing Yang, Yang Li, Xiaobin Li, Tianwei Jia, Haojie He, Qun Yu,Na Guo, Yun He, Peng Yu*,Yang Yang*.Multivalent neuraminidase hydrolysis resistant triazole-sialoside protein conjugates as influenza-adsorbents.Chinese Chemical Letters.2018,1:76-80.
(16)Hua Sun, Weina Ding, Xiaotong Song, Dong Wang, Mingzhu Chen, Kaili Wang, Yazhou Zhang, Peng Yuan, Ying Ma, Runling Wang, Robert H. Dodd, Yongmin Zhang, Kui Lu,* and Peng Yu *.Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5, 6-disubstituted derivatives.Bioorganic & Medicinal Chemistry Letters.2017, 27:3226-3230.
(17)Hua Sun,*, Dong Wang, Xiaotong Song, Yazhou Zhang, Weina Ding, Xiaolin Peng, Xiaoting Zhang, Yashan Li, Ying Ma Runling Wang and Peng Yu*,Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: α‑Glucosidase and α‑Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects,Journal of Agricutural Food Chemistry,2017, 65:1574-1581
(18)Dong Wang,* Yuxi Wang, Junjie Zhao, Meng Shen, Jianyong Hu, Zhenlin Liu, Linna Li, Furen Xue, and Peng Yu*.Strategic Approach to 8‑Azacoumarins.Organic letters.2017, 19(5):984-987.
(19)Kui Lu,* Ke Yang, Xiaoliang Jia, Xing Gao, Xia Zhao, Guojun Pan, Yantao Ma, Qiyao Huang, and Peng Yu*.Total Synthesis of I3,II8‐Biapigenin and Ridiculuflavone A.Organic Chemistry Frontiers.2017, 4, 578-586.
(20)Zhen Liu, Qi Zheng, Wenzhu Chen, Meng Wu, Guojun Pan, Ke Yang, Xuzhe Li, Shuli Man, Yuou Teng, Peng Yu*, Wenyuan Gao*.Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways.European Journal of Medicinal Chemistry.2017,125:760-769.
(21)Yuou Teng,Xuzhe Li,Ke Yang,Xuehui Li,Zijun Zhang,Luyao Wang,Zhijie Deng,Binbin Song, Zhihong Yan,Yongmin Zhang,Kui Lu,*Peng Yu*.Synthesis and antioxidant evaluation of desmethylxanthohumolanalogs and their dimers. European Journal of Medicinal Chemistry.2017, 125 :335-345.
(22)Kui Lu,*, Yantao Ma, Meile Gao,Yan Liu, Ming Li,Chuanming Xu,Xia Zhao,*,and Peng Yu*. 1,4-Addition Ugi Reaction Using Cyclic α,β-Unsaturated Ketone as Substrate. Organic letters. 2016, 18, 5038-5041.

已授权专利:
(1)一种能够对细胞培养板实现局部可控加热的水浴锅. ZL 201821308969.5
(2)一种8-氮杂色酮的合成方法.ZL 201611202287.1
(3)天然双黄酮I3, II8-Biapgienin 和 Ridiculuflavone A 的制备. ZL 201610839344.0
(4)谷胱甘肽敏感的两亲性聚乙二醇-羟基喜树碱偶联物. ZL 201610845743.8
(5)天然黄酮Anastatin B的衍生物及制备和应用. ZL 201610325752.4
(6)一类香豆素取代黄酮类衍生物及其制备方法和应用. ZL 201510216650.4
(7)胡枝子酚E1类化合物及制备方法和应用. ZL 201510052946.7
(8)四环吲哚生物碱衍生物及其制备和应用. ZL 201510043073.3
(9) 3,5-二异戊烯基,2,4,4'-三羟基查尔酮及其衍生物的用途和制备. ZL 201410483832.3
(10)一种合成2,5-二羰基哌嗪类化合物的方法.ZL 201410007958.3
(11)双吲哚类化合物及合成方法.ZL 201410246013.7
(12)2,5,6-三取代-3(2H)-苯并呋喃酮类衍生物及应用. ZL 201410217214.4
(13)一种1-(苯基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚衍生物的制备及其在抗肿瘤药物中的应用. ZL 201210531525.9
(14)1,3- 取代-5- 乙酰氨基吲哚酮类化合物及其在抗肿瘤药物中的应用. ZL 201310540828.1
(15)一类新型4,5- 取代-7- 甲酸甲酯吲哚二酮衍生物及其在抗肿瘤药物中的应用. ZL 201310540643.0
(16)聚乙二醇和脂溶性化合物的连接物在生物催化中的应用. ZL 201110054137.1


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Email: yupeng@tust.edu.cn

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