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副教授



申雁冰,博士,yh1187银河网站副教授,博士生导师。天津市“131”人才计划第二层次人选, 天津市“131”创新型人才团队和天津市创新人才推进计划重点领域创新团队成员,中国微生物学会和中国化工学学会员,入选首届天津市高校“优秀青年教师资助计划”和天津市高校中青年骨干创新人才培养计划。

主讲课程:
本科生:《生物药物合成原理》,《生物制药工艺学》
研究生:《生物制药技术》

主要教学研究及成果情况:
参与教改项目1项,参编专著1部。指导本科生获得校级优秀本科毕业论文4项。
[1] 天津市高等学校本科教学质量与教学改革研究计划项目:制药工程专业特色建设的综合改革与实践,2014-2016;
[2] 参与指导本科生获全国大学生生命科学创新创业大赛创新组一等奖1项,二等奖2项;
[3] 指导本科生获批国家和天津市大学生创新创业训练计划项目各1项;
[4] 指导本科生获第十五届“挑战杯”天津市大学生课外学术科技作品竞赛二等奖1项;
[5] 指导本科生获得第五届药学专业大学生自主创新学术论坛二等奖1项。

科研领域及方向:
[1] 具有重要医药价值的工业微生物菌种筛选与分子改造;
[2] 微生物细胞催化反应与过程调控。

科研项目情况:
[1] 国家合成生物学重点研发计划项目“甾体激素从头生物合成的人工细胞创建及应用”子课题,2020-2024,子课题负责人;
[2] 国家自然科学基金项目:分枝杆菌合成雄烯二酮过程中辅因子的作用机制及调控,2020-2023,项目主持人;
[3] 国家自然科学基金项目:环糊精介质中甾体结构与微生物催化活性的关系和基于活化效应的作用机制研究,2015-2017,项目主持人;
[4] 天津市合成生物技术创新能力提升行动项目“新型C19甾体药物合成关键基因元件挖掘与进化改造”,2019-2022,项目主持人;
[5] 天津市自然科学基金“简单节杆菌 C1,2 位脱氢酶底物催化特异性机制研究及理性改造” 2018-2021,项目主持人;
[6] 天津市科技特派员项目:基于环糊精和细胞共循环的甾体绿色生物转化工艺研究,2018-2019,项目主持人;
[7] 天津市应用基础与前沿技术研究计划项目:“环糊精介质中甾体结构与C1,2脱氢反应的变化规律及机制” 2013-2016,项目主持人;
[8] 天津市高等学校科技发展基金计划项目“超分子介质生物催化中主体化合物的选择策略研究”,2012 -2015,项目主持人;
[9] 教育部科学技术研究重点项目“AD生物合成关键酶KsdD的稳定性分析与菌株构建”2014-2016,排名第二;
[10] 国家863计划子课题“生物法合成去氢胆固醇技术研究”,2011-2016,排名第二;
[11] 国家自然科学基金项目:“Mycrobacterium neoaurum 生物合成AD的产物迁移机制与调控”,2013-2016,排名第二;
[12] 天津市科技计划项目“环糊精介质中甾体药物及中间体生物转化工艺中试”,2015-2018,排名第二。

主要学术成果:
先后发表各类科研论文50余篇,参编专著1部,授权或申请发明专利50余项。发表的主要学术论文有:
[1] Zhao YQ, Shen YB*, Ma S, Luo JM, Ouyang W, Zhou HJ, Tang R, Wang M*. Poduction of 5a-androstene-3, 17-dione from phytosterols by co-expression of 5a-reductase and glucose-6-phosphate dehydrogenase in engineered Mycobacterium neoaurum, Green Chemistry, 2019, 21, 1809-1815(一区Top, IF:9. 48)
[2] Zhou XL,Zhang Y*,Shen YB,Zhang X,Zan ZH,Luo JM,Xia ML,Wang Min*.Efficient repeated batch production of androstenedione using untreated cane molasses by Mycobacterium neoaurum driven by ATP futile cycle, Bioresource Technology. 2020, 309:123307(一区Top, IF:7.539)
[3] Zhang Y,Zhou XL,Wang XM,Wang L,Xia ML,Luo JM,Shen YB*,Wang M*.Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum[J]. Microbial Cell Factories,2020,19:13. (二区, IF:4.187)
[4] Ma, QY, Gao, XZ, Bi, XY, Tu LN, Xia ML, Shen YB*, Wang M*. Isolation, characterisation, and genome sequencing of Rhodococcus equi: a novel strain producing chitin deacetylase [J]. Scientific reports, 2020, 10(1), 4229. (IF:3.998)
[5] Su LQ, Xu SP, Shen YB*, Xia ML, Ren XX, Wang LF, Shang ZH, Wang M*. 2020. The sterol carrier hydroxypropyl-β-cyclodextrin enhances the metabolism of phytosterols by Mycobacterium neoaurum. Applied and Environmental Microbiology. 2020,86(15): e00441-20(二区Top, IF:4.016)
[6] Zhou XL, Zhang Y, Shen YB*, Zhang X, Xu SP, Shang ZH, Xia ML, Wang M*, Efficient production of androstenedione by repeated batch fermentation in waste cooking oil media through regulating NAD+/NADH ratio and strengthening cell vitality of Mycobacterium neoaurum,Bioresource Technology, 2019, 279: 209-217. (一区Top, IF:7.539)
[7] Tang R, Shen YB*, Wang M*, Zhou HJ, Zhao YQ. Highly efficient synthesis of boldenone from androst-4-ene-3,17-dione by Arthrobacter simplex and Pichia pastoris ordered biotransformation[J]. Bioprocess and Biosystems Engineering. 2019, 42(6), 933-940(IF:2.419)
[8] Tang R, Shen YB, Xia ML, Tu LN, Luo JM, Geng YH, Gao T, Zhou HJ, Zhao YQ, Wang M*. A highly efficient step-wise biotransformation strategy for direct conversion of phytosterol to boldenone. Bioresource Technology, 2019, 283:242–250(一区Top, IF:7.539)
[9] Shen YB, Niu LL, Yu ZQ, Wang M*, Shang ZH, Yang Y. Sodium alginate-grafted β-cyclodextrins as a matrix for immobilized Arthrobacter simplex for cortisone acetate biotransformation, Applied Surface Science, 2018,444:42-47. (一区Top, IF:6.182)
[10] Liu JJ, Wang LF, Shen YB*, Su LQ, Wang M*. Effect of β-cyclodextrins Derivatives on Steroids Biotransformation by Arthrobacter simplex, Applied Biochemistry and Biotechnology, 2018, 185(4), 1004-1013. (IF:2.277)
[11] Su LQ, Shen YB*, Xia ML, Shang ZH, Xu SP, An XJ, Wang M*. Overexpression of cytochrome p450 125 in Mycobacterium: a rational strategy in the promotion of phytosterols biotransformation, Journal of Industrial Microbiology and Biotechnology, 2018, 45(10): 857-86. (二区,IF:2.993)
[12] Su LQ, Shen YB*, Zhang WK, Gao T, Shang ZH, Wang M*. Cofactor engineering to regulate NAD+/NADH ratio with its application to phytosterols biotransformation[J]. Microbial Cell Factories, 2017, 16(1):182.
[13] Shen YB, Yu ZQ, Yang X, Wang F, Wang M*. A new technique for promoting cyclic utilization of cyclodextrins in biotransformation, Journal of Industrial Microbiology and Biotechnology, 2017,44(1):1-7.
[14] Wang LF, Shen YB, Liu MJ, Tang R, Wang M*. Influence of imidazolium-based ionic liquids on the steroid biotransformation by Arthrobacter simplex[J]. Journal of Chemical Technology & Biotechnology, 2018,93(2):426-431.
[15] Qin N, Shen YB*, Yang X, Su LQ, Tang R, Li W, Wang M*. Site-directed mutagenesis under the direction of in-silico protein docking modeling reveals the active site residues of 3-ketosteroid-Δ1-dehydrogenase from Mycobacterium neoaurum, World Journal of Microbiology and Biotechnology, 2017,33:146.
[16] Su LQ , Shen YB*, Gao T, Luo JM, Wang M*. Improvement of AD biosynthesis and cofactors analysis response to enhanced oxygen transfer by oxygen vectors in Mycobacterium neoaurum TCCC11979, Applied Biochemistry and Biotechnology, 2017,182:1564-1574.
[17] Qiao YQ, Shen YB*, Huang W, Wang YP, Ren JJ, Xia T, Wang M. Biocatalyst-mediated production of 11α, 15α-dihydroxy derivatives of androst-1, 4-dien-3, 17-dione, Journal of Bioscience and Bioengineering, 2017,123(6):692-697.
[18] Tang R, Shen YB, Wang M*, Zhai Y, Gao Q. Highly chemoselective and efficient production of 2,6-difluorobenzamide using Rhodococcus ruber CGMCC3090 resting cells.[J]. Journal of Bioscience & Bioengineering, 2017,124 (6): 641-646.
[19] Shen YB, Wang LF, Liang JT, Tang R, Wang M*. Effects of two kinds of imidazolium-based ionic liquids on the characteristics of steroid-transformation Arthrobacter simplex[J]. Microbial Cell Factories, 2016, 15:118.
[20] Shen YB, Wang F, Wang YP, Zhao Q, Wang M*. Cyclic utilization of HP-b-CD in the bioconversion of cortisone acetate by Arthrobacter simplex[J]. Biotechnol Lett, 2016, 38: 597-602.
[21] Liu Y, Shen YB*, Qiao YQ, Su LQ, Li C, Wang M*. The effect of 3-ketosteroid-Δ1-dehydrogenase isoenzymes on the transformation of AD to 9α-OH-AD by Rhodococcus rhodochrous DSM43269[J]. Journal of Industrial Microbiology and Biotechnology, 2016, 43: 1303-1311.
[22] Liu Y, Cao F, Xiong H, Shen YB, Wang M*. Application of 2,4-Dinitrophenyl-hydrazine(DNPH) in High-Throughput Screening for Microorganism Mutants Accumulating 9α-Hydroxyandrost-4-ene-3,17-dione (9α-OHAD)[J]. PLOS ONE, 2016, 10(11).
[23] Shen YB, Liang JT, Li HN, Wang M*. Hydroxypropyl-β-cyclodextrin-mediated alterations in cell permeability, lipid and protein profiles of steroid-transforming Arthrobacter simplex[J]. Applied Microbiology and Biotechnology, 2015, 99(1): 387-397.
[24] Xie RL, Shen YB, Qin N, Wang YB, Su LQ, Wang M*. Genetic differences in ksdD influence on the ADD/AD ratio of Mycobacterium neoaurum[J]. Journal of Industrial Microbiology and Biotechnology, 2015, 42: 507-513.
[25] Chen X, Shen YB, Liang QK, Flavell R, Hong ZY, Yin ZN, Wang M*. Effect of Bavachinin and its derivatives on T cell differentiation[J]. International Immunopharmacology, 2014, 19(2): 399-404.
[26] Shen YB, Wang M*, Li XD, Zhang JL, Sun H, Luo JM. Highly efficient synthesis of 5-cyanovaleramide by Rhodococcus ruber CGMCC3090 resting cells. Journal of Chemical Technology and Biotechnology. 2012, 87: 1396-1400.
[27] Shen YB, Wang M*, Li HN, Wang YB, Luo JM. Influence of hydroxypropyl-β-cyclodextrin on phytosterol biotransformation by different strains of Mycobacterium neoaurum. Journal of Industrial Microbiology and Biotechnology. 2012, 39(9), 1253-1259.
[28] Cui LY, Shen YB, Guo XD,Wang YZ, Luo JM, Wang M*.Effects of HP-β-CD on growth and morphology of Absidia coerulea. World Journal of Microbiology and Biotechnology, 2012, 28(8):2723-2729.
[29] Shen YB, Wang M*, Zhang LT , Ma YH, Ma B , Zheng Y , Liu H, Luo JM. Effects of hydroxypropyl-β-cyclodextrin on cell growth, activity, and integrity of steroid-transforming Arthrobacter simplex and Mycobacterium sp. Applied Microbiology and Biotechnology, 2011,90(6): 1995-2003.

授权发明专利:
[1] 申雁冰,王敏,于子棋,商志华,夏梦雷. 海藻酸钠接枝衍生环糊精固定化细胞及其应用,中国,专利号:ZL 2017104526560
[2] 申雁冰,王敏,刘晶晶,汤睿,骆健美,郑宇.一种用于植物甾醇侧链降解反应的底物处理方法. 中国,专利号:ZL 201610270775.X
[3] 申雁冰;王敏;王芳;梁静婷;骆健美;郑宇. 醋酸可的松转化中固定化细胞和环糊精循环利用的方法. 2017.3.22 中国,专利号: ZL201310665015.5
[4] 王敏,申雁冰,于子棋,谢晓林,骆健美. 海藻酸钠接枝天然环糊精固定化细胞及其应用,中国,专利号:ZL2017104526503
[5] 王敏,申雁冰,牛璐璐,杨妍,骆健美. 一种真菌催化甾体生物转化的方法,中国,专利号:ZL2017104526448
[6] 王敏,申雁冰,刘晶晶,苏立秋,郑宇,骆健美. 一种雄烯二酮的制备方法.中国,专利号:ZL201610278447.4
[7] 王敏,申雁冰,梁静婷,赵清,骆健美,郑宇. 醋酸可的松生物催化中环糊精介质的循环利用方法[P]. 2017.2.8 中国,专利号: ZL 201310666576.7
获奖情况:
优良果醋饮料发酵菌种选育及发酵关键技术研究与应用,获2015年度天津市科学技术进步奖一等奖。

联系方式:
办公地点:天津经济技术开发区第十三大街29号yh1187银河网站
邮政编码:300457
办公电话:022-60601256
传 真:022-60602298
Email: shenyb@tust.edu.cn

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