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Professors


Xixian Xie


TITLE: Professor, College of Biotechnology, Tianjin University of Science and Technology 

Deputy Director, National and Local United Engineering Lab of Metabolic Control Fermentation Technology


EDUCATION: University of Science and Technology of China, B.S. (2000)
Third Institute of Oceanography, M.S. (2004)

Xiamen University, Ph.D. (2007)


PROFESSIONAL EXPERIENCE:
1.Professor of College of Biotechnology, Tianjin University of Science & Technology, 2014-present.
2.Associate Professor of College of Biotechnology, Tianjin University of Science & Technology, 2010-2014.
3.Visiting scholar, Department of Bioengineering, Rice University, 2012-2013.
4.Assistant Professor of College of Biotechnology, Tianjin University of Science & Technology, 2007-2010.

5.Research Assistant, Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, 2000-2007.


SERVICE:
1.Deputy Secretary-general, Chinese Amino acid technology service center, 2010-present.
2.Trustee, Tianjin Society for Microbiology, 2012-present.

3.Trustee, Tianjin Society for Food, 2016-present.


RESEARCH:

Research interest is mainly concerned with the microbial technology related to the industrial production of amino acid, nucleotide and derivatives. The main focus is on the systematic analysis of industrial microorganism, including Corynebacterium glutamicum, Escherichia coli and Bacillus subtilis, and on the pathway design and manipulation using recombinant DNA technology to improve cellular properties and to achieve advanced engineering strains for specific product accumulation. Another main research aspect is the optimization and scale-up of fermentation. The comprehensive optimization techniques combining metabolic flux analysis contribute to improve the productivity of fermentation process. 


SELECTED PUBLICATIONS:
1.Ning Y, Wu X, Zhang C, Xu Q, Chen N, Xie X*. Pathway construction and metabolic engineering for fermentative production of ectoine in Escherichia coli. Metab Eng, 2016, 36:10-18.  IF: 8.201
2.Wu H, Li Y, Ma Q, Li Q, Jia Z, Yang B, Xu Q, Fan X, Zhang C, Chen N, Xie X*. Metabolic engineering of Escherichia coli for high-yield uridine production. Metab Eng, 2018, 49:248-256.  IF: 8.201
3.Zhang C, Li Y, Ma J, Liu Y, He J, Li Y, Zhu F, Meng J, Zhan J, Li Z, Zhao L, Ma Q, Fan X, Xu Q, Xie X, Chen N*. High production of 4-hydroxyisoleucine in Corynebacterium glutamicum by multistep metabolic engineering. Metab Eng, 2018, 49:287-298.  IF: 8.201
4.Fan X, Wu H, Jia Z, Li G, Li Q, Chen N, Xie X*. Metabolic engineering of Bacillus subtilis for the co-production of uridine and acetoin. Appl Microbiol Biotechnol, 2018, 102(20):8753-8762.  IF: 3.340
5.Zhang C, Qi J, Li Y, Fan X, Xu Q, Chen N, Xie X*. Production of α-ketobutyrate using engineered Escherichia coli via temperature shift. Biotechnol Bioeng, 2016, 113(9):2054-9.  IF: 4.126
6.Li Y, Wei H, Wang T, Xu Q, Zhang C, Fan X, Ma Q, Chen N, Xie X*. Current status on metabolic engineering for the production of l-aspartate family amino acids and derivatives. Bioresour Technol, 2017, 245:1588-1602.  IF: 5.651
7.Ma Y, Chen Q, Cui Y, Du L, Shi T, Xu Q, Ma Q, Xie X, Chen N. Comparative genomic and genetic functional analysis of industrial L-leucine- and L-valine-producing Corynebacterium glutamicum strains. J Microbiol Biotechnol, 2018, doi: 10.4014/jmn.1805.05013.  IF: 1.650
8.Fan X, Wu H, Li G, Yuan H, Zhang H, Li Y, Xie X*, Chen N. Improvement of uridine production of Bacillus subtilis by atmospheric and room temperature plasma mutagenesis and high-throughput screening. PLoS One, 2017, 12(5):e0176545.  IF: 3.234
9.Qian Ma, Quanwei Zhang, Qingyang Xu, Chenglin Zhang, Yanjun Li, Xiaoguang Fan, Xixian Xie*, Ning Chen, Systems metabolic engineering strategies for the production of amino acids. Synth Syst Biotechnol, 2017, 2: 87-96.
10.Gui Y, Ma Y, Xu Q, Zhang C, Xie X*, Chen N. Complete genome sequence of Corynebacterium glutamicum CP, a Chinese l-leucine producing strain. J Biotechnol, 2016, 220:64-65.  IF: 2.871
11.Li Y, Sun L, Feng J, Wu R, Xu Q, Zhang C, Chen N, Xie X*. Efficient production of α-ketoglutarate in the gdh deleted Corynebacterium glutamicum by novel double-phase pH and biotin control strategy. Bioprocess Biosys Eng, 2016, 39(6):967-76.  IF: 1.997
12.Xie X, Liang Y, Liu H, Liu Y, Xu Q, Zhang C, Chen N*. Modification of glycolysis and its effect on the production of L-threonine in Escherichia coli. J Ind Microbiol Biotechnol, 2014, 41:1007-1015.  IF: 2.439
13.Wang J, Wen B, Wang Jian, Xu Q, Zhang C, Chen N, Xie X*. Enhancing l-isoleucine production by thrABC overexpression combined with alaT deletion in Corynebacterium glutamicum. Appl Biochem Biotech, 2013, 171(1):20-30.   IF: 1.893
14.Guo X, Wang J, Xie X, Xu Q, Zhang C, Chen N*. Enhancing the supply of oxaloacetate for L-glutamate production by pyc overexpression in different Corynebacterium glutamicum. Biotechnol Lett. 2013, 35(6):943-950. IF: 1.736
15.Liang J, Zhang D, Guo X, Xu Q, Xie X, Zhang C, Bai G, Xiao X, Chen N*. At-line near-infrared spectroscopy for monitoring concentrations in temperature-triggered glutamate fermentation. Bioprocess Biosyst Eng. 2013, 36(12):1879-1887.  IF: 1.823
16.Fang H, Xie X, Xu Q, Zhang C, Chen N*. Enhancement of cytidine production by coexpression of gnd, zwf, and prs genes in recombinant Escherichia coli CYT15. Biotechnol Lett. 2013, 35(2):245-251. IF: 1.736
17.Liu Q, Cheng Y, Xie X, Xu Q, Chen N*. Modification of tryptophan transport system and its impact on production of L-tryptophan in Escherichia coli. Bioresour Technol. 2012, 114:549-554.  IF: 4.75
18.Xie X, Huo W, Xia J, Xu Q, Chen N*. Structure-activity relationship of a cold-adapted purine nucleoside phosphorylase by site-directed mutagenesis. Enzyme Microb Technol. 2012, 51(1):59-65.  IF: 2.592
19.Xie X, Xu L, Shi J, Xu Q, Chen N*. Effect of transport proteins on L-isoleucine production with the L-isoleucine-producing strain Corynebacterium glutamicum YILW. J Ind Microbiol Biotechnol. 2012, 39(10): 1549-1556.  IF: 2.321
20.Shen T, Liu Q, Xie X, Xu Q, Chen N*. Improved production of tryptophan in genetically engineered Escherichia coli with TktA and PpsA overexpression. J Biomed Biotechnol. 2012, 2012:605219.  IF: 2.88
21.Xie X, Xia J, Xu Q, He K, Lu L, Chen N*. Low-molecular-mass homotrimer purine nucleotide phosphorylase: characterization and application in enzymatic synthesis of nucleoside antiviral drugs. Biotechnol Lett. 2011, 33(6):1107-1112. IF: 1.683

22.Xie X, Wang G, Xia J, Chen N. Characterization of a recombinant cold-adapted purine nucleoside phosphorylase and its application in ribavirin bioconversion. World J Microbiol Biotechnol. 2011, 27:1175-1181.  IF: 1.532


PATENT FILINGS:
1.Hydroxy-and dicarboxylic-fat synthesis by microbes, US 2015/0225753 A1.
2.Xylose-induced genetically engineered bacteria used for producing ectoine and use thereof, PCT/CN2017/088284.

3.Genetically engineered bacteria with high-yield uridine and its construction method and use, PCT/CN2018/072020.


CONTACT INFORMATION:
Address:No. 29, 13th Avenue, TEDA, Tianjin 300457, P. R. China
Tel: +86-(0)22-60601251
Fax: +86-(0)22-60602298
Email: xixianxie@tust.edu.cn
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