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Associate Professors

Dr Yu Aiqun
Associate Professor

Personal details:
Family name: Yu
First name: Aiqun
E-mail: yuaiqun@tust.edu.cn
Tel: +86 022 60602723

Affiliations:
College of Biotechnology, Tianjin University of Science and Technology, China 
State Key Laboratory of Food Nutrition and Safety, China
Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, China
Tianjin Key Laboratory of Industrial Microbiology, China 

Research Interest:
Engineering microorganisms for efficient production of biofuels, biochemicals and biopharmaceuticals.
Application of advanced synthetic biology tools to facilitate production of biofuels, biochemicals and biopharmaceuticals.

Education:
2009.9-2012.12. Doctor of science in microbiology, College of life sciences, Nankai University, Tianjin, China. 
2006.9-2009.6. Master of science in microbiology, College of life sciences, Fujian Normal University, Fuzhou, China.
2002.9-2006.6. Bachelor of science in biotechnology, College of life sciences, Shandong Normal University, Jinan, China.

Professional Experience:
2016.9-, Associate Professor, College of Biotechnology, Tianjin University of Science and
Technology, Tianjin, China.
2013.12-2016.5, Postdoctoral Research Fellow, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
2013.3-2013.11, Postdoctoral Research Fellow, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore. 

Current Projects:
Metabolic engineering of Yarrowia lipolytica for microbial production of naturally occurring terpene — limonene.
Metabolic engineering of Yarrowia lipolytica for microbial production of naturally occurring terpene — bisabolene.

Selected Publications:
Ai-Qun Yu*, Ya-Kun Zhao, Ya-Ru Pang, Zhi-Hui Hu, Cui-Ying Zhang, Dong-Guang Xiao, Matthew Wook Chang, Susanna Su Jan Leong. An oleaginous yeast platform for renewable 1‑butanol synthesis based
on a heterologous CoA‑dependent pathway and an endogenous pathway. Microbial Cell Factories, 2018, 17: 166.
Ai-Qun Yu*, Ya-Ru Pang, Zhi-Hui Hu, Dong-Guang Xiao. Advances in metabolic engineering for the microbial production of short branched-chain fatty acids and short branched-chain alcohols. Microbiology China, 2018, 45(1): 173-180.
Ya-Ru Pang, Zhi-Hui Hu, Dong-Guang Xiao, Ai-Qun Yu*. Advances in metabolic engineering for the microbial production of naturally occurring terpenes-limonene and bisabolene: a mini review. Chinese Journal of Biotechnology, 2018, 34(1): 24-33.
Ai-Qun Yu, Nina Kurniasih Pratomo Juwono, Jee Loon Foo, Susanna Su Jan Leong, Matthew Wook Chang*. Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids. Metabolic Engineering, 2016, 34: 36-43.
Ai-Qun Yu, Nina Kurniasih Pratomo Juwono, Tee-Kheang Ng, Hua Ling, Han-Saem Cho, Susanna Su Jan Leong, Matthew Wook Chang*. Genetic engineering of an unconventional yeast for renewable biofuel and biochemical production. Journal of Visualized Experiments, 2016, 115, e54371.
Ai-Qun Yu, Nina Kurniasih Pratomo Juwono, Susanna Su Jan Leong, Matthew Wook Chang*. Production of fatty acid-derived valuable chemicals in synthetic microbes. Frontiers in Bioengineering and Biotechnology, 2014, 2: 78.
Ai-Qun Yu, Jian-Chun Zhu, Biao Zhang, Lai-Jun Xing, Ming-Chun Li*. Knockout of fatty acid desaturase genes in Pichia pastoris GS115 and its effect on the fatty acid biosynthesis and physiological consequences. Archives of Microbiology, 2012, 194(12): 1023-1032. 
Ai-Qun Yu, Tong-Lei Shi, Biao Zhang, Lai-Jun Xing, Ming-Chun Li*. Transcriptional regulation of desaturase genes in Pichia pastoris GS115. Lipids, 2012, 47(11): 1099-1108.
Ai-Qun Yu, Tong-Lei Shi, Biao Zhang, Lai-Jun Xing, Ming-Chun Li*. Effects of low temperature and exogenous unsaturated fatty acids on fatty acid desaturase gene expression of Mortierella alpina ATCC 16266. Acta Microbiologica Sinica, 2012, 52(11): 1369-1377. 
Ai-Qun Yu, Jian-Chun Zhu, Biao Zhang, Lai-Jun Xing, Ming-Chun Li*. Effects of different carbon sources on the growth, fatty acids production, and expression of three desaturase genes of Mortierella alpina ATCC 16266. Current Microbiology, 2011, 62(5): 1617-1622.
Ai-Qun Yu, Xian-Zhang Jiang, Xiao-Feng Xia, Song-Gang Wu, Jian-Zhong Huang*. Isolation and molecular identification of Mucor sp. EIM-10. Chinese Journal of Bioprocess Engineering, 2009, 7(2): 74-78.
Wei Suong Teo, Hua Ling, Ai-Qun Yu, Matthew Wook Chang*. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel. Biotechnology for Biofuels, 2015, 8: 177.
Tong-Lei Shi, Ai-Qun Yu, Ming Li, Meng Zhang, Lai-Jun Xing, Ming-Chun Li*. Identification and characterization of a novel C20-elongase gene from the marine microalgae, Pavlova viridis, and its use for the reconstitution of two pathways of long-chain polyunsaturated fatty acids biosynthesis in Saccharomyces cerevisiae. Biotechnology Letters, 2013, 35(8): 1271-1282.
Tong-Lei Shi, Ai-Qun Yu, Ming Li, Xiu-Yuan Ou, Lai-Jun Xing, Ming-Chun Li*. Identification of a novel C22-Δ4-producing docosahexaenoic acid (DHA) specific polyunsaturated fatty acid desaturase gene from Isochrysis galbana and its expression in Saccharomyces cerevisiae. Biotechnology Letters, 2012, 34(12): 2265-2274.
Jian-Zhong Huang, Xian-Zhang Jiang, Xiao-Feng Xia, Ai-Qun Yu, Ruo-Yu Mao, Xiao-Feng Chen, Bao-Yu Tian*. Cloning and functional identification of delta5 fatty acid desaturase gene and its 5’-upstream region from marine fungus Thraustochytrium sp. FJN-10. Marine Biotechnology, 2011, 13(1): 12-21.
Zhi-Hui Hu, Bing-Xu Chen, Ai-Qun Yu, Dong-Guang Xiao*. Strategies of metabolic engineering Saccharomyces cerevisiae to produce plant-derived D-limonene. Chinese Journal of Biotechnology, 2018, 34(1): 24-33.
Hao Lan, Xiu-Yuan Ou, Ming Li, Ai-Qun Yu, Tong-Lei Shi, Lai-Jun Xing, Ming-Chun Li*. Expression of Δ6-fatty acid elongase gene from Mortierella alpina in Pichia pastoris. Acta Scientiarum Naturalium Universitatis Nankaiensis, 2013, 46(2): 100-106.

Teaching:
Yeast Technology, Downstream Processing of Bioengineering, Fermentation Engineering, Scientific Writing.

Address:
Room 107, Building 2
College of Biotechnology, Tianjin University of Science and Technology
No.29 the 13th Street TEDA, Tianjin 300457, China

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