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Associate Professors


Hua Sun, Ph.D, Associate Professor of Tianjin University of Science and Technology. She received a bachelor"s degree in pharmaceutical chemistry from Shenyang Pharmaceutical University in 2001, and a Ph.D degree in pharmaceutical chemistry from Shenyang Pharmaceutical University in 2007. She worked as a visiting scholar at State University of New York, Upstate Medicinal University from March 2012 to May 2013. She was selected as the training program for young and middle-aged backbone talents in Tianjin. She was a youth committee member of Pharmaceutical Association Tianjin pharmaceutical chemistry branch.


RESEARCH INTERESTS:
- Drug Discovery:          Design, synthesis and biological activity evaluation of new chemical compounds for the treatment of diabetes and cancer.

- Organic Process Research:  Development and optimization of organic reactions in pharmaceutical industry and their transfer to a larger scale for manufacture.


MAIN COURSES:
- For bachelors:        Medicinal Chemistry, Pharmaceutical Technology Experiments 
- For Graduate students: Comprehensive analysis of organic spectrums, Pharmaceutical technology and Engineering

SELECTED PUBLICATIONS (as First author or Corresponding author):
[1] Hua Sun, Xiaotong Song, Yunchang Tao, Ming Li, Ke Yang, Hang Zheng, Zongxin Jin, Robert H. Dodd, Guojun Pan, Kui Lu, Peng Yu. Synthesis and α-glucosidase inhibitory and glucose consumption-promoting activities of flavonoid-coumarin hybrids. Future Medicinal Chemistry. 2018, 10(9): 1055-1066.
[2] Mei-yan Wang, Xian-chao Cheng, Xiao-bo Li, Ying Ma, Yu Li, Lan-lan Zang, Yu-qing Duan, Xiao-tong Song, Peng Yu, Hua Sun*, Run-ling Wang *. Synthesis, Biological Evaluation and Mechanistic Studies of Novel Dual Inhibitors by Targeting α-Glucosidase and Protein Tyrosine Phosphatase 1B. Chemical Biology & Drug Design. 2018, 92(3):1647-1656.
[3] Sun, Hua; Wang, Dong; Song, Xiaotong; Zhang, Yazhou; Ding, Weina; Peng, Xiaolin; Zhang, Xiaoting; Li, Yashan; Ma, Ying; Wang, Runling; Yu, Peng, Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: alpha-Glucosidase and alpha-Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects. , Journal of Agricultural and Food Chemistry, 2017, 65: 1574~1581
[4] Sun, Hua; Ding, Weina; Song, Xiaotong; Wang, Dong; Chen, Mingzhu;Wang, Kaili; Zhang, Yazhou; Yuan, Peng; Ma, Ying; Wang, Runling; Dodd, Robert H.; Zhang, Yongmin; Lu, Kui; Yu, Peng, Synthesis of 6-hydroxyaurone analogues and evaluation of their alpha-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives, Bioorganic Medicinal Chemistry Letters. 2017,27(15): 3226~3230
[5] Hua Sun, Yazhou Zhang, Weina Ding, Xue Zhao, Xiaotong Song, Dong Wang, Yashan Li, Kailin Han, Yang Yang, Ying Ma, Runling Wang, Dong Wang, Peng Yu. Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as a-glucosidase inhibitors. European Journal of Medicinal Chemistry 2016, 123, 365-378. 
[6] Hua Sun, Partick Y. K. Yue, Shao-Rong Wanga, Lihong Huo, Ying Zhao, Songbo Xie, Jens Vindahl Kringelum, Ole Lund, Olivier Taboureau, Jun Zhou, Ricky N. S. Wong and Wei-Shuo Fang. Synthesis and Biological Evaluations Triterpenoids-Jacaranone Conjugates. Medicinal Chemistry, 2016, 12, 1-11. 
[7] Hua Sun, Ya Nan Lei, Hao Meng Wang, Yu Ou Teng, Hong Ye Zhao, Qing Wei Yao, and Peng Yu. First total synthesis and cytotoxicity of naturally occurring Lespedeza E1. Chemistry of natural Compounds. 2016, 52(4): 896~898 
[8]Hua Sun, Yashan Li, Xiaoting Zhang, Yanan Lei, Weina Ding, Xue Zhao, Haomeng Wang, Xiaotong Song, Qingwei Yao, Yongmin Zhang, Ying Ma, Runling Wang, Tao Zhu and Peng Yu. Synthesis, α-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones. Bioorganic Medicinal Chemistry Letters. 2015, 25: 4567–4571. 
[9] Kailin Han, Yashan Li, Yazhou Zhang, Yuou Teng, Ying Ma, Meiyan Wang, Runling Wang, Weiren Xu, Qingwei Yao, Yongmin Zhang,  Haijuan Qin, Hua Sun*, and Peng Yu*. Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitors.  Bioorganic Medicinal Chemistry Letters. 2015, 25: 1471–1475.
[10] Hua Sun, Ting Liu, Yan-Jun Shen, Li-Ming Zhang, Min Wang.Preparation and Crystal Structure of 15α-Hydroxyl-oleanolic Acid. Chinese Journal of Structural Chemistry. 2010, 29: 1798-1801.  
[11] SUN Hua, LIU Ting, SHEN Yan-Jun, ZHANG Li-Ming, WANG Min. Preparation and Crystal Structure of 15α-Hydroxyl-oleanolic Acid. Chinese J. Struct. Chem. 2010, 29(12), 1798-1801. 
[12] Hua SUN, Wei-Shuo FANG and Chun HU. An Efficient Semi-synthesis and Structure Revision of a cytotoxic triterpenoid 25-acetoxy-3α-hydroxyolean-12-en- 28-oic acid from Liquidamber styraciflua. J. Asian Nat. Prod. Research. 2008, 10(4), 271-276. 
[13] Hua SUN, Wei-Shuo FANG, Wen-Zhao WANG, and Chun HU. Structure-activity relationships of oleanane- and ursane type triterpenoids. Botanical Studies. 2006, 47: 339-368. 

BOOKS: 
[1] Medicinal Chemistry, Tsinghua University press. 2013. (“12th Five-Year plan" Planning teaching materials for general higher education)
[2] Medicinal Chemistry, China Medical Science and Technology Press. 2012.(Teaching materials for education and pharmacy in national colleges and Universities)

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