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Lectures

Meng Xin, assistant professor; Master supervisor; Tianjin "131" talent level 3rd; Tianjin Science and Technology Commissioner; Member of Chinese Chemistry Society; Member of Tianjin Microbiology Society.


Lecture: 
Undergraduate course: Chemical Pharmaceutical Technology. 

Graduate course: Glycoengineering; Pharmaceutical production quality management engineering.


Research fields:
Research areas include molecular medicine and carbohydrate chemistry.
[1] Chemoenzymatic synthesis of natural oligosaccharide fragments with important biological activities and study on Structure-Activity Relationship (SAR) of functional molecules containing carbohydrate;
[2] Screening of antitumor carbohydrate drugs based on the TACA to prepare the oligosaccharide medicine or glycoprotein;

[3] Development and development of glycopeptide vaccine.


Projects:
[1] National Natural Science Foundation of China (No. 21502139), Novel regioselective chemoenzymatic synthesis of disialyl TF and its fluorinated derivatives and their application in tumor vaccines, 2016-2018,Project Leader. 
[2] Science and Technology Commissioner Foundation of Tianjin (No. 15JCTPJC56200), Development of a new PGL-tb1 tuberculosis vaccine, 2015-2016, Project Leader.
[3] Foundation of Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education and Tianjin Key Lab of Industrial Microbiology (Tianjin University of Science & Technology) (No. 2016IM102), Enzymatic synthesis of prebiotic sialyl lactose by immobilized enzyme, Project Leader.
[4] Laboratory Innovation Foundation of Undergraduate (Tianjin University of Science & Technology) (No. 1604A306), 2016-2017, Project Leader.
[5] Ministry of Health Major Scientific and Technological Projects (No. 2015ZX09J15105-002-003), Study on culture and purification of adenovirus, 2015-2018,Participant.
[6]  National Natural Science Foundation of China(No. 81503086),Design, screening and antitumor activity of human skin flap inhibitors, 2016-2018,Participant.
[7] Enterprise project(No. 1400040028), Development of thirteen valent pneumococcal conjugate vaccine, 2014-2016, Participant.
[8] Enterprise project(No. 1400040027), Clinical development of quadrivalent meningitis vaccine, 2014-2016, Participant. 

[9] Enterprise project(No. 1500040057), Development of surface protein of Streptococcus pneumoniae, 2014-2017, Participant.


Publications:
[1] Hai-Peng Liu#, Xin Meng#, Qun Yu, Yun-Chang Tao, Hao-Jie He, Yao Yu, Hao Chang, Yun He, Peng Yu*, Yang Yang*. Synthesis of S-sialyl polymers as efficient polyvalent influenza inhibitors and captures. Journal of Carbohydrate Chemistry. 2018,37 (1):18-29. 
[2] Xin Meng, Meibing Yang, Yang Li, Xiaobin Li, Tianwei Jia, Haojie He, Qun Yu, Na Guo, Yun He, Peng Yu, Yang Yang. Multivalent neuraminidase hydrolysis resistant triazole-sialoside protein conjugates as influenza-adsorbents. Chinese Chemical Letters, 2018, 29, 76–80.
[3] De-Min Wang#, Xin Meng#, Xiao-Bin Li, Hao-Jie He, Teng-Fei Zhao, Tian-Wei Jia, Yun He,Yang Yang* and Peng Yu*. Modification of bovine serum albumin with  aminophenylboronic acid as glycan sensor based on surface plasmon resonance and isothermal titration calorimetry. Heterocyclic Communications, 2017, 23(3): 237–243.
[4] Xin Meng, Chuanming Ji, Chao Su, Di Shen, Yaxin Li, Peijie Dong, Ding Yuan, Mengya Yang, Song Bai, Demei Meng, Zhenchuan Fan, Yang Yang*, Peng Yu*, Tao Zhu*. Synthesis and immunogenicity of PG-tb1 monovalent glycoconjugate. European Journal of Medicinal Chemistry, 2017, 134 (7V), 140-146. 
[5] Yang Yang, Hai-Peng Liu, Qun Yu, Mei-Bing Yang, De-Min Wang, Tian-Wei Jia, Hao-Jie He, Yun He, Hai-Xia Xiao, Suri S. Iyer, Zhen-Chuan Fan, Xin Meng*, Peng Yu*. Multivalent S-sialoside protein conjugates block influenza hemagglutinin and neuraminidase. Carbohydrate Research, 2016, 435, 68–75. 
[6] Pan Guojun, Xiao Na, Shen Di, Chen Minglang, Li Yi, Lu Kui,Yang Yang, Meng Xin*, Yu Peng*, Synthesis and hypoglycemic activity of novel quercetin conjugates [J],Chin. J. Org. Chem,2017, 37 (1) :133-140.
[7] Xin Meng, Wenlong Yao,Jiansong Cheng,Xu Zhang,Lan Jin,Hai Yu,Xi Chen,Fengshan Wang*,Hongzhi Cao*,Regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes. Journal of the American Chemical Society,2014, 136(14): 5205-5208. (IF=13.038,JCR一区Top)
[8] Xin Meng,Feng Tian*,Jian Yang,Chun-Nian He,Nan Xing,Fan Li,Chitosan and alginate polyelectrolyte complex membranes and their properties for wound dressing application. Journal of Materials Science: Materials in Medicine,2010,21(5): 1751-1759. (IF=2.272,JCR二区)
Patents:
[1] Meng Xin, Yu Peng, Zhu Tao, Su Chao, Yuan Ding, Dong Peijie, Li Xiao, Liang Jianmei, Lian Xujing. Synthesis and application of sialated TF antigen and its fluoride derivatives, CN201711385873.9 

[2] Meng Xin, Zhu Tao, Yu Peng, Ji Chuanming, Pan Guojun, Chen he, Su Chao, Shen Di. A PGL-tb1 oligosaccharide conjugate of Mycobacterium tuberculosis and its preparation and application, CN201610788095.7


Zip code:300457
Office tel.:022-60912562
Fax:022-60602298
Email:mengxin@tust.edu.cn
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