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Associate Professors


ZhangJian  Ph.D, Associate professor


Education
2008/09-2013/01, Doctor of biochemical engineering,school of chemical engineering,, Tianjin University
2000/07-2003/06, Master of food science,college of food science, Southwest University 
1996/07-2000/06, Bachelor of food science,college of food science and engineering, Gansu Agricultural University

Professional Experiences
Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, college of biotechnology, Tianjin University of Science and Technology  
Time:2012-current 
Position:Associate professor
Time:2005-2012
Position: Research associate
Time:2003-2005
Position:Research assistant
Tianjin SF—Bio Industrial Bio-tec Co., Ltd, Tianjin University of Science and Technology (Joint-Supervision)
Time:2014.9-2017.5
Position:Postdoctoral fellow 
Department of physiology and Biophysics, Virginia Federal University (VCU)
Time:2015.6-2015.9
Position:Visiting scholar 
London Research and Development Centre, Agriculture and Agri-Food Canada 
Time:2018.1-2019.1
Position:Visiting scholar 

Teaching
Brewing Technology, Frontiers of Bioengineering, Course Design of Bioengineering

Research Interests
Safety regulation of food biological manufacturing
Rapid detection and control the hazards formed in food biological manufacturing.
Brewing technology of fruit wine

Analysis of microbiota and their metabolites in the brewing process and improve the brewing technology.


Fungal metabolism and regulation 
To discover bioactive fungal metabolites using living strategy-based approach; to investigate the biosynthetic pathways of important metabolites for the production of structurally diversified metabolite libraries and through metabolic manipulations of the producing strains to improve the production of targeted compounds.

Main scientific research projects (In recent five years)
1.National Natural Science Foundation: The molecular basis and regulatory mechanism on the formation of biogenic amines during the brewing of traditional Chinese rice wines.
2.National Natural Science Foundation: Formation mechanism of ethyl carbamate in fermented foods.
3.Tianjin enterprise postdoctoral innovation project: Development of molecular detection method for ochratoxin A producing strain
4.Tianjin funded training selected outstanding postdoctoral program of internationalization.
5.Enterprise entrusted project: Investigation the content of Ochratoxin A in agricultural products in China.

Recent Publications (In recent five years)
[1] Jian Zhang, Xiaojuan Zhu, Ruitao Xu, Qiang Gao, Depei Wang, Ying Zhang. Isolation and identification of histamine-producing Enterobacteriaceae from Qu fermentation starter for Chinese rice wine brewing. International Journal of Food Microbiology 2018, 281: 1–9
[2] Ying Zhang, Yan Li, Xiaojuan Zhu, Min Li, Haoyu Chen, Xiaoling Lv, Jian Zhang *. Development and validation of a solid-phase extraction method coupled with HPLC-UV detection for the determination of biogenic amines in Chinese rice wine. Food Additives & Contaminants: Part A. 2017,34(7): 1172−1183
[3] Jian Zhang, Liuyang Zhu, Haoyu Chen, Min Li, Xiaojuan Zhu, Qiang Gao, Depei Wang, and Ying Zhang *. A Polyketide Synthase Encoded by the Gene An15g07920 Is Involved in the Biosynthesis of Ochratoxin A in Aspergillus niger. Journal of Agricultural and Food Chemistry, 2016, 64 (51): 9680–9688. 
[4] Jian Zhang *, Guoxin Liu, Ying Zhang, Qiang Gao, Depei Wang, and Hao Liu *. Simultaneous Determination of Ethyl Carbamate and Urea in Alcoholic Beverages by High-Performance Liquid Chromatography Coupled with Fluorescence Detection. Journal of Agricultural and Food Chemistry, 2014, 62(13), 2797–2802
[5] Jian Zhang, Ying Zhang, Yi Wen, Qiang Gao, Depei Wang, Mengmeng Zhao, Ye Hand and Zhijiang Zhou *. A Compatible Membrane Process for Separation and Concentration of Pediocin PA-1 from Fermentation Broth. Separation Science and Technology, 2014, 49(13): 1978–1984
[6] Li Hou, Ling Liu, Hongfei Zhang, Lin Zhang, Lan Zhang, Jian Zhang, Qiang Gao, Depei Wang*. Functional analysis of the mitochondrial alternative oxidase gene (aox1) from Aspergillus niger CGMCC 10142 and its effects on citric acid production. Applied Microbiology and Biotechnology, 2018, 102(18): 7981-7995.
[7] Chuanyou Chang, Jun Zhang, Shenxi Ma, Lin Wang, Depei Wang, Jian Zhang, Qiang Gao*. Purification and characterization of glutamate decarboxylase from Enterococcus raffinosus TCCC11660. Journal of Industrial Microbiology & Biotechnology, 2017, 44(6):817-824.
[8] Pingping Tian, Peng Cao, Dong Hu, Depei Wang, Jian Zhang, Lin Wang, Yan Zhu, Qiang Gao*. Comparative metabolomics reveals the mechanism of avermectin production enhancement by S-adenosylmethionine. Journal of Industrial Microbiology & Biotechnology, 2017, 44(4):595-604.. 
[9] Lu Wang, Jianhua Zhang, Zhanglei Cao, Yajun Wang, Qiang Gao, Jian Zhang, Depei Wang. Inhibition of oxidative phosphorylation for enhancing citric acid production by Aspergillus niger. Microbial Cell Factories (2015) 14(1):7.
[10] Vice-editor, Wine Production Technology (2nd Edition), Beijing: Chemical Industry Press, May 2012.

Patents 
[1] Zhang Jian, Zhang Ying, Zhou Zhijiang, Han Ye. A method for isolation and extraction of Staphylococcin lactate PA-1 from fermentation broth, 2015.4, China, ZL 201310237 976.6
[2]. Wang Depei, Gao Ling FA, Li Lei, Zhang Jian, Gao Qiang. Screening and Application of a Low-yielding Ethyl Carbamate Wine Yeast, 2012.10, China, ZL2011110129484.6
[3]. Gao Ling FA, Zhang Ying, Gao Qiang, Song Lei, Feng Yu, Zhang Jian, Wang Depei. A production method and application of high-yield gamma aminobutyric acid. 2012.8, China, ZL 201110051732.X
[4]. Gao Ling FA, Zhang Ying, Feng Yu, Ren Xue, Zhang Jian, Yang Feng. A method for the preparation of gamma aminobutyric acid vinegar, 2013.1, China, ZL 200910069735.9 
[5] Zhang Jian, Wang Xiaoxia, Zhang Ying, Gaoqiang, Wang Depei. A ochratoxin A producing strain, 2014.10, China, CN201410577019.2.
[6] Zhang Jian, Li Min, Zhang Ying. Nucleic acid aptamers specifically recognizing ochratoxin A and their preparation methods, 2017.8.31, China, CN201710771917.5.

Honors & Awards
“Complex mutation breeding of high-yield citrate strain and its green fermentation application” won the 1st prize of China Light Industry Council Science and Technology Progress Award in 2016
   “Development of microbial fermented feed for cow” won the 3rd prize of Tianjin Science and Technology Invention Award in 2009.

Contact information
Address: Room 107, Building No. 2, College of Biotechnology, Tianjin University of Science and Technology, TEDA, Tianjin, 300457, China. 
Office phone: 022-60602715
E-mail: zj96sk@tust.edu.cn

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