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Professors

  

 Tongcun Zhang, man, Ph.D, professor. Distinguished professor of Tianjin, member of the Tianjin CPPCC. He is also a member of the Academic Committee of the Key Laboratory (Jiangnan University) of the Ministry of Education for Industrial Biotechnology, member of Academic Committee of Tianjin Key Laboratory of protein science (Nankai University), director of Chinese Fermentation Industry Association polyol branch, director of Chinese Society of Biochemistry and Molecular Biology, director of Tianjin Microbial Society, director of Tianjin Cell Biology Society, Senior member of the American Cancer Society, member of American College of Cardiology, and Special expert of China Health Food Association.


Research field and direction
[1] Molecular mechanism of abnormal transcriptional regulation in major diseases such as cardiovascular diseases and tumors and related new drug development
[2] Mechanism of functional genes and transcriptional regulation of probiotics and industrial microorganisms
[3] The regulation and mechanism of intestinal microecology and health

Fundings
[1] NSFC: The mechanism of Stat3 inhibiting myocardin inducing cardiac hypertrophy, 800 thousand RMB, 2013-2016.
[2] 863 Program: Food microbe genome modification(functional gene analysis, safety and functional evaluation of probiotics), 2 million 150 thousand RMB, 2012-2015.
[3] 863 Program: Preparation of natural polysaccharides and development of functional polysaccharides, 580 thousand RMB, 2012-2015.
[4] Tianjin Application Foundation and Frontier Technology Research Plan: Identification and molecular breeding of L. casei HZ1 novel antihypertensive peptide, 2014-2017.
[5] NSFC: The mechanism and differentiation of vascular smooth muscle cells induced by Myocardin and estrogen receptor, 2009-2012.
[6] NSFC: Myocarin inducing cardiac hypertrophy and its mechanism, 2007-2009.
[7] 863 Program: Key technologies for the targeted screening and functional development of probiotics, 2008-2010.
[8] 973 Program: Research on the structural mechanism of epigenetics (topic 4-research on the structure and function of important proteins in epigenetic regulation), 2009-2014
[9] Ph.D. Programs Foundation of Ministry of Education of China: The mechanism of promoting estrogen metabolism by MRTF-A, 2012-2014.
[10] Tianjin Applied Foundation and Frontier Technology Research Project: Interaction of Myocardin family transcription factor and src-1 and its role in drug metabolism, 2007-2009.
[11] Science and Technology Innovation Special Project of Dongli district, Tianjin city: Research and industrialization of recombinant pig transfer factor rTF, 2011-2012.
[12] Haihe Scholars Start Fundation of Tianjin University of Science and Technology: The role and mechanism of Myocardin in the pathogenesis of atherosclerosis, 2008-2010.
[13] Transverse project: Establishment of D- tagog lactobacillus bioconversion production system, 2013-2014.
[14] Transverse project: Optimization of fermentation conditions for nucleotide production of bacillus glutamate, 2012-2013.

Main academic achievements
He has published more than 110 scientific papers, including more than 70 papers included in SCI or EI, participated in the preparation of 6 teaching materials or monographs, and authorized or applied for 9 invention patents. The main academic papers published are as follows:
[1] Xing WJ, Liao XH, Wang N, Zhao DW, Zheng L, Zheng L, Dong J, Zhang TC*. MRTF-A and STAT3 promote MDA-MB-231 cell migration via hypermethylating BRSM1. IUBMB Life. 2015 Apr 9.(IF 2.755)
[2] Li XM, Luo XG, Wang N, Zhou H, Si CL, Li K, Ma N, Zhang TC*. The extract of Hypericum ascyron L. induces bacterial cell death through apoptosis pathway. J Ethnopharmacol. 2015 May 26; 166: 205-210.( IF 2.939) 
[3] Li XM, Luo XG, Zhang CZ, Wang N, Zhang TC*. Quality evaluation of Hypericum ascyron extract by two-dimensional high-performance liquid chromatography coupled with the colorimetric 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide method. J Sep Sci. 2015, 38(4): 576-584.(IF 2.594)
[4] Rui Zhang, Nan Wang, Man Zhang, Li-Nan Zhang, Zhi-Xia Guo,  Xue-Gang Luo, Hao Zhou, Hong-Peng He, Zhang TC*. Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells. Stem Cells International. 2015. (IF 2.806)
[5] Li M, Wang N, Gong HQ, Li WZ, Liao XH, Yang XL, He HP, Cao DS, Zhang TC*. Ca²⁺signal-induced cardiomyocyte hypertrophy through activation of myocardin. GENE. 2015.15;557(1):43-51.(IF 2.082)
[6] Li XM*, Luo XG*#, Si CL, Wang N, Zhou H, He JF, Zhang TC#. Antibacterial active compounds from Hypericum ascyron L. induce bacterial cell death through apoptosis pathway. Eur J Med Chem. 2015, 96: 436-444. (*Co-first author with student; #Co-corresponding authors)(IF 3.432)
[7] Xiang-Zhu Shu, Li-Nan Zhang, Rui Zhang, Cai-Jiao Zhang , Hong-Peng He, Hao Zhou, Nan Wang , Zhang TC*. Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in humanumbilical vein endothelial cells. GENE. 2015 May 25;563(1):17-23.(IF 2.082)
[8] Ruo-Lei Jian, Li-Bin Mao, Yao Xu, Xiao-Fan Li, Feng-Po Wang, Xue-Gang Luo, Hao Zhou, Hong-Peng He, Nan Wang, Zhang TC*. Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells. GENE. 2015 May 10;562(1):107-16.(IF 2.082)
[9] Xing-Hua Liao, Nan Wang, Dong-Wei Zhao, De-Liang Zheng, Li Zheng, Wen-Jing Xing, Hao Zhou, Dong-Sun Cao, Zhang TC*. NF-κB (p65) negatively regulates myocardin-induced cardiomyocyte hypertrophy through multiple mechanisms. Cellular Signalling. 2014, 26 (12), 2738-2748.(IF 4.471)
[10] He H, Liu X, Wang D, Wang Y, Liu L, Zhou H, Luo X, Wang N, Ji B, Luo Y, Zhang TC*. SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells. GENE. 2014,553 (2):98-104. (IF2.19)
[11] Xing-Hua Liao, Nan Wang, Long-Yue Liu, Li Zheng, Wen-Jing Xing, Dong-Wei Zhao, Xue-Guang Sun, Peng Hu, Jian Dong, Zhang TC*. MRTF-A and STAT3 synergistically promote breast cancer cell migration. Cellular Signalling. 2014,26(11):2370-2380.(IF 4.471)
[12] Xing-Hua Liao, Yan-Qi Li, Nan Wang, Li Zheng, Wen-Jing Xing, Dong-Wei Zhao, Ting-Bao Yan, Yue Wang, Long-Yue Liu, Xue-Guang Sun, Peng Hu, Hao Zhou, Zhang TC*. Re-expression and epigenetic modification of maspin induced apoptosis in MCF-7 cells mediated by myocardin. Cellular Signalling. 2014,26(6):1335-1346.(IF 4.304)
[13] Gu XC, Luo XG, Wang CX, Ma DY, Wang Y, He YY, Li W, Zhou H, Zhang TC*. Cloning and analysis of Bile Salt Hydrolase Genes from Lactobacillus plantarum TH1 CGMCC No. 8198. Biotechnol Lett. 2014,36(5): 975-983.(IF1.853)
[14] Xing-Hua Liao, Yue Wang, Nan Wang, Ting-Bao Yan, Wen-Jing Xing, Li Zheng, Dong-Wei Zhao, Yan-Qi Li, Long-Yue Liu, Xue-Guang Sun, Peng Hu, Zhang TC*. Human chorionic gonadotropin (hCG) decreases human breast cancer cell proliferation and promotes differentiation. IUBMB Life. 2014,66(5):352-360.(IF 2.789)
[15] Luo XG, Zhang CL, Zhao WW, Liu ZP, Liu L, Mu A, Guo S, Wang N, Zhou H, Zhang TC*. Histone methyltransferase SMYD3 promotes MRTF-A - mediated transactivation of MYL9 and migration of MCF-7 breast cancer cells. Cancer Lett. 2014,344(1): 129-137.(IF 4.238)
[16] Li XM, Luo XG, Ma N, Li K, Li W, Ma DY, Zhang TC*. Quality and antitumour activity evaluation of extract of Hypericum ascyron. Biomed Chromatogr. 2014,36(5): 975-984. (IF1.966) 
[17] Xing–Hua Liao, Da–Lin Lu, Nan Wang, Long–Yue Liu, Yue Wang, Yan–Qi Li,Ting–Bao Yan, Xue–Guang Sun, Peng Hu and Zhang TC*. Estrogen receptor a mediates proliferation of breast cancer MCF–7 cells via a p21/PCNA /E2F1-dependent pathway. The FEBS journal. 2014,281(3): 927-42.(IF 4.25)
[18] Zhipeng Liu, Xuegang Luo, Lei Liu, Wenwen Zhao, Shu Guo, Yu Guo, Nan Wang, Hongpeng He, Xinghua Liao, Wenjian Ma, Hao Zhou, Zhang TC*. Histone acetyltransferase p300 promotes Megakaryoblastic leukemia 1- mediated transactivation of catechol-O-methyltransferase. Acta Bioch Bioph Sin. 2013,45(12): 1002-1010.(IF 1.807)
[19] Chunling Zhang, Xuegang Luo, Lei Liu, Shu Guo, Wenwen Zhao, Ai Mu, Hao Zhou, Nan Wang, Zhang TC*. MRTF-A is upregulated by 17β-estradiol and promotes migration of MCF-7 breast cancer cells via transactivation of MYL9 and CYR61. Acta Bioch Bioph Sin. 2013,45(11): 921-927.(IF 1.807)
[20] Nan Wang, Rui Zhang, Shui-Jing Wang, Chun-Ling Zhang, Li-Bin Mao,Chun-Yu Zhuang, Yan-Yang Tang, Xue-Gang Luo, Hao Zhou, Zhang TC*. Vascular endothelial growth factor stimulates endothelial differentiation rom mesenchymal stem cells viaRho/myocardin-related transcription actor-A signaling pathway. The International Journal of Biochemistry & Cell Biology. 2013,45(7) :1447-1456.(IF 4.634)
[21] Nan Wang, Yao Xu, Tao Qin, Feng-Po Wang, Lin-Lin Ma, Xue-Gang Luo, Zhang TC*. Myocardin-related transcription factor-A is a key regulator in retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells. Gene. 2013,523(2) : 178-186.(IF 2.341)
[22] Feng Lin, Nan Wang, Zhang TC*. The role of endothelial-mesenchymal transition in development and pathological process. IUBMB Life. 2012,64(9):717-723.(IF 4.514)
[23] Nan Wang, Guang-Da Ren, Zhen Zhou, Yao Xu, Tao Qin, Ru-Fa Yu, Zhang TC*. Cooperation of Myocardin and Smad2 in Inducing Differentiation of Mesenchymal Stem Cells into Smooth Muscle Cells. IUBMB Life. 2012,64(4):331-339.(IF 3.514)
[24] Jiao Lu, Jinlei Tang,Yi Liu, Xinna Zhu, Zhang TC*,Xueli Zhang .Combinatorial modulation of galP and glk gene expression for improved alternative glucose utilization. Appl Microbiol Biotechnol.2012, 93(6):2455-2462.(IF 3.425)
[25] Luo XG, Tian WJ, Ni M, Jing XL, Lv LH, Wang N, Jiang Y, Zhang TC*. Soluble expression of active recombinant human tissue plasminogen activator derivative (K2S) in Escherichia coli. Pharm Biol. 2011,49(6): 653-657.(IF 0.878)
[26] Liao XH, Wang N, Liu QX, Qin T, Cao B, Cao DS, Zhang TC*. Myocardin-Related Transcription Factor-A Induces Cardiomyocyte Hypertrophy. IUBMB Life.2011, 63(1):54-61.(IF 3.514)
[27] J. Wang, Zhang TC* and X. Liu. Preliminary crystallographic analysis of the N-terminal domain of FILIA, a protein essential for embryogenesis. crystallization communications.2010, 66(9):1111-1114.(IF 0.563)
[28] Xiao-Lan Jing, Xue-Gang Luo, Wen-Jing Tian, Li-Hui Lv, Yong Jiang, Nan Wang, Zhang TC*. High-Level Expression of the Antimicrobial Peptide Plectasin in Escherichia coli. Curr Microbiol.2010, 61(3):197-202.(IF 1.51)
[29] Xue-Gang Luo, Tao Xi, Shu Guo, Zhi-Peng Liu, Nan Wang, Yong Jiang and Zhang TC*. Effects of SMYD3 overexpression on transformation, serum dependence, and apoptosis sensitivity in NIH3T3 cells. IUBMB Life. 2009,61(6): 679-684.(IF 3.578)
[30] Nan Wang, Zhen Zhou, Xinghua Liao and Zhang TC*. Role of microRNAs in cardiac hypertrophy and heart failure. IUBMB Life. 2009,61(6):566-571.(IF 3.578)
[31] Xin W*, Zhang TC*, Cao D, Wang Z, Antos CL, Li S, Wang Y, Olson EN, Wang DZ., Myocardin induces cardiac hypertrophy. Circ Res. 2006 Apr 28;98(8):1089-97(IF9.8) (*Co- first author).
[32] Faucette S*, Zhang TC*, Moore R,Sueyoshi T,Omiecinski C,Lecluyse E,Negishi M,Wang H, Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers. J Pharmacol Exp Ther. 2006 Oct 13(IF 4.908) (*Co- first author).
[33] Wang H,Faucette S, Zhang TC,et al,Validation of a human CAR variant(hCAR3) as the in vitro predictor for PXR independent CYP2B6/CYP3A4 induction Dug Meta Rev. 38:115, 179, 2006.(IF5.135).

Awards
He was awarded the 2012 advanced society worker of tianjin association of science and technology, the 2012 excellent master"s thesis of tianjin university of science and technology, the 2013 excellent master"s thesis of tianjin university of science and technology, and the 2014 excellent master"s thesis of tianjin university of science and technology.

Contacts
Office address: College of Biotechnology, Tianjin University of Science and Technology, no. 29, 13 Street, Tianjin Economic-Technological Development Area (TEDA), Tianjin.
Zip code: 300457
Office phone: 022-60600518,60602099
Fax: 022-60602298
Email: tony@tust.edu.cn
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