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Professors


Wang Nan, Ph. D., Professor, School of bioengineering, Tianjin University of Science and Technology. Candidate of "Tianjin 131 Innovative Talents Training Project Level 1". Team Leader of “Tianjin 131 Innovative Talents Team”. "Excellent Young Teachers Subsidy Program". Tianjin Youth"Innovation, Entrepreneurship and Excellence"advanced personal honorary title. She is a member of the Chinese Society of Cell Biology, the Chinese Society of Biochemistry and the Stem Cell Branch of the Chinese Society of Cell Biology. She is a peer reviewer of several SCI journals, such as Stem Cells, Experimental Cell Research, Journal of Cellular and Molecular Medicine, Journal of Cellular Physiology, BMC Cancerand so on.

At present, she is mainly engaged in the transcriptional regulation and epigenetic modification of cardiovascular diseases and stem cell differentiation. At the same time, she also carries out the regulatory role and mechanism of probiotics and functional factors in body development and intestinal disease regulation. She presided over 8 scientific research projects at or above the provincial and ministerial level, participated in many national and provincial projects, and published more than 80 papers, of which more than 20 SCI papers were published by the first or corresponding author.


Lecturer course:
Undergraduate:《cell biology》, 《Introduction to biopharmaceutical》, 《frontier progress of Pharmaceutical Engineering》

Graduate student: 《molecular pharmacology》


Main teaching research and achievements
She has participated in one teaching reform project, won one award for teaching achievement at school level, published three teaching reform papers and compiled one textbook.
[1]Tianjin University of Science and Technology Educational and Teaching Reform Project: Establishment of a new bilingual teaching system of Pharmacology for pharmaceutical engineering specialty, 2012-2014. Fifth participants.
[2]Xuegang Luo, Tongcun Zhang, Nan Wang, Hua Sun, Yuou Teng, Hongpeng He. Construction and practice of bilingual teaching system for pharmacology of pharmaceutical engineering specialty. Tianjin University of Science and Technology. The teaching achievement award is the first prize. March 2018.
[3]N Wang,M Li,TC Zhang,XG Luo。Discussion on the Teaching Methods of Pharmaceutical Engineering Education。Creative Education,2013,3 (7B):80-82。
Juke Wang, Xuegang Luo, Nan Wang, Bingye Dai, Tongcun Zhang. Relying on the provincial and ministerial level key laboratories of universities to cultivate undergraduates" scientific research ability. Light industry education in China, 2012,04:66-68。
[5] Xuegang Luo, Tongcun Zhang, Nan Wang, Yong Jiang. Experience in classroom teaching of pharmaceutical preparations engineering. Pharmaceutical Education, 2008, 24(4): 24-25。

[6] 《Pharmacology (Bilingual)》, Huazhong University of Science and Technology press,2013年8月。


Research field and direction
[1] Epigenetic modification regulates angiogenesis and remodeling
[2] LncRNA regulates smooth muscle phenotype transformation and arteriosclerosis

[3] Regulation of probiotics and functional factors on body development and intestinal diseases


Fundings:
1. "Tianjin University of Science and Technology Microecological Regulation and Molecular Pharmacology Team". Tianjin 131 Innovative Talents Team Leader. 201801-2020, 1.2 million.
2. Food Nutrition Function and Safety Assessment Based on Intestinal Microecological Regulation (TD13-5015). Head of Innovation Team of Tianjin Institutions of Higher Learning. 2018.01-2020.12, 1.8 million.
3. "Health function of probiotics and mechanism of food nutrient metabolism based on intestinal microbiology" is the fourth sub-project of "Research on the mechanism of probiotics and intestinal microorganisms affecting human cell differentiation and development" (2017YFD0400304). National key research and development plan. 2017/01-2020/12, 231.4 million, sub subject 1.1 million, sub project leader.
4.DNA demethylation specifically regulates the differentiation and angiogenesis of endothelial cells (17JCZDJC33600). Tianjin Natural Science Fund. 201704-202004, 0.2 million, project leader.
5. Molecular mechanism of MRTF-A regulating CYR61-mediated differentiation of mesenchymal stem cells into endothelial cells (31171303). National Natural Science Foundation of China. 2012-2015, 0.6 million, project leader.
6. MRTF participates in the regulation of differentiation of mesenchymal stem cells into insulin secreting cells (212010). Key projects of science and technology research of the Ministry of education. 2012-2014, 0.1 million, project leader.
7.TGF-beta activates Myocardin family to induce differentiation of bone marrow mesenchymal stem cells (30800561). National Natural Science Foundation of China Youth Fund. 2009-2011, 0.2 million, project leader.
8. Molecular control of bone marrow mesenchymal stem cells differentiating into smooth muscle cells (09JCZDJC18100). Tianjin Key Project of Applied Foundation and Frontier Technology Research Program, 2009-2011, 0.2 million. project leader.
9. Myocardin regulates the differentiation of bone marrow mesenchymal stem cells (20080409). Tianjin University of Science and Technology talent introduction fund, 2008-2010. project leader.
10. Preparation of natural polysaccharides and preparation of functional polysaccharides (2012AA021505). The national high technology research and development plan (863). 2012-2015, 0.58 million. third participants.
11. Genome transformation of food microorganisms (2012AA022108). The national high technology research and development plan (863). 201211-201512, 2.1 million. sixth participants.
12. MRTF-A promotes estrogen metabolism and its mechanism (20111208110001). Funded by the doctoral program, special research fund. 2012-2014, 1.20 million. Third participants.
The interaction between 13.Myocardin and SRC-1 and its function in drug metabolism (07JCYBJC16400). Tianjin Natural Science Foundation project. 2007-2010, 80 thousand. Third participants.
14.Research on the key technologies of targeted screening and functional development of probiotics (2008AA10Z336). The National 863 plan, 2007-2010110 million. Sixth participants.

15. Membrane linked protein mediated signal transduction of neural stem cell proliferation and differentiation (30470404). The National Natural Science Foundation of China. 2005-2007. Third participants.


Main academic achievements
She has published more than 80 scientific papers, including more than 20 papers indexed by SCI as the first author or corresponding author. She also participated in 6 patents for invention. The main academic papers published are as follows:
1.Kuramoto K#, Wang N#, Fan Y, Zhang W, Schoenen FJ, Frankowski KJ, Marugan J, Zhou Y, Huang S, He C*. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 2016 Sep;12(9):1460-71. (# Co-first author) (SCI, 1区, IF=9.108)
2.Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, He C. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 2016 Oct 28:141-56. (SCI, 1区, IF=9.108)
3.Zhang R#, Wang N#*, Zhang LN, Huang N, Song TF, Li ZZ, Li M, Luo XG, Zhou H, He HP, Zhang XY, Ma W, Zhang TC*. Knockdown of Dnmt1 and Dnmt3a Promotes the Angiogenesis of hMSCs Leading to Arterial Specific Differentiation. Stem Cells. 2016 May;34(5):1273-83. (SCI, 1区, IF= 5.902)
4.Liao XH#, Wang N#, Zhao DW, Zheng DL, Zheng L, Xing WJ, Ma WJ, Bao LY, Dong J, Zhang TC*. STAT3 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin. J Biol Chem. 2015 Aug 7;290(32):19641-52. (SCI, 2区, IF= 4.258)
5.Zhuang C, Yuan Y, Song T, Wang H, Huang L, Luo X, He H, Huo L, Zhou H, Wang N*, Zhang T*. miR-219a-5p inhibits breast cancer cell migration and epithelial-mesenchymal transition by targeting myocardin-related transcription factor A. Acta Biochim Biophys Sin (Shanghai). 2017 Oct 25:1-10. 
6.Mao L, Wang H, Ma F, Guo Z, He H, Zhou H, Wang N*. Exposure to static magnetic fields increases insulin secretion in rat INS-1 cells by activating the transcription of the insulin gene and up-regulating the expression of vesicle-secreted proteins. Int J Radiat Biol. 2017 Aug;93(8):831-840. 
7.Xing-Hua Liao#, Nan Wang#*, Dong-Wei Zhao, De-Liang Zheng, Li Zheng, Wen-Jing Xing, Hao Zhou, Dong-Sun Cao, Tong-Cun Zhang*. NF-κB (p65) negatively regulates myocardin-induced cardiomyocyte hypertrophy through multiple mechanisms. Cellular Signalling. 2014 Dec;26(12):2738-48.. (# Co-first author) (*, corresponding author) (SCI, 2区, IF=4.132) 
8.Xing-Hua Liao#, Yan-Qi Li#, Nan Wang#,*, Li Zheng, Wen-Jing Xing, Dong-Wei Zhao, Ting-Bao Yan, Yue Wang, Long-Yue Liu, Xue-Guang Sun, Peng Hu, Hao Zhou, Tong-Cun Zhang*. Re-expression and epigenetic modification of maspin induced apoptosis in MCF-7 cells mediated by myocardin. Cellular Signalling. 2014 Mar 6;26(6):1335-1346. (# Co-first author) (*, corresponding author) (SCI, 2区;IF=4.132) 
9.Li M#, Wang N#*, Zhang J, He HP, Gong HQ, Zhang R, Song TF, Zhang LN, Guo ZX, Cao DS, Zhang TC*. MicroRNA-29a-3p attenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytes. Gene. 2016 Jul 1;585(1):44-50. (SCI, 3区;IF=2.319) 
10.Li M, He HP, Gong HQ, Zhang J, Ma WJ, Zhou H, Cao DS, Wang N*, Zhang TC*. NFATc4 and myocardin synergistically up-regulate the expression of LTCC α1C in ET-1-induced cardiomyocyte hypertrophy. Life Sci. 2016 Jun 15;155:11-20. (SCI, 3区;IF=2.685)
11.Zhang R#, Wang N#*, Zhang M , Zhang LN, Guo ZX, Luo XG, Zhou H, He HP, Zhang TC*. Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells. Stem Cells Int. 2015; 2015:534758. (SCI, 3区;IF= 3.687)
12.Li W#, Wang N#*, Li M, Gong H, Liao X, Yang X, Zhang T*. Protein kinase Cα inhibits myocardin-induced cardiomyocyte hypertrophy through the promotion of myocardin phosphorylation. Acta Biochim Biophys Sin (Shanghai). 2015 Sep;47(9):687-95. 
13.Xing WJ#, Liao XH#, Wang N#*, Zhao DW, Zheng L, Zheng L, Dong J, Zhang TC*. MRTF-A and STAT3 promote MDA-MB-231 cell migration via hypermethylating BRSM1. IUBMB Life. 2015 Mar;67(3):202-17. (SCI, 3区;IF= 2.653)
14.Shu XZ, Zhang LN, Zhang R, Zhang CJ, He HP, Zhou H, Wang N*, Zhang TC*. Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells. Gene. 2015 Mar 5.563, 17-23. (SCI, 3区;IF= 2.319)
15.Jian RL, Mao LB, Xu Y, Li XF, Wang FP, Luo XG, Zhou H, He HP, Wang N*, Zhang TC*. Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells. Gene 2015 May 10;562(1):107-16. (SCI, 3区;IF= 2.319)
16.Man Li#, Nan Wang#*, Hui-Qin Gong, Wei-Zong Li, Xing-Hua Liao, Xiao-Long Yang, Hong-Peng He, Dong-Sun Cao, Tong-Cun Zhang*. Ca2+ signals induced cardiomyocyte hypertrophy through activation of myocardin. Gene. 2015 Feb 15;557(1):43-51..(# Co-first author) (*, corresponding author) (SCI, 3区;IF= 2.319)
17.Xing-Hua Liao#, Nan Wang#*, Long-Yue Liu, Li Zheng, Wen-Jing Xing, Dong-Wei Zhao, Xue-Guang Sun, Peng Hu, Jian Dong, Tong-Cun Zhang*. MRTF-A and STAT3 synergistically promote breast cancer cell migration. Cellular Signalling. 2014 Nov;26(11):2370-80. (# Co-first author) (*, corresponding author) (SCI, 2区)
18.Liao XH#, Wang Y#, Wang N#,*, Yan TB, Xing WJ, Zheng L, Zhao DW, Li YQ, Liu LY, Sun XG, Hu P, Zhang TC*. Human chorionic gonadotropin decreases human breast cancer cell proliferation and promotes differentiation. IUBMB Life. 2014 May;66(5):352-60. (# Co-first author) (*, corresponding author) (SCI, 3区)
19.Xing-Hua Liao#, Da-Lin Lu#, Nan Wang#, Long-Yue Liu, Yue Wang, Yan-Qi Li, Ting-Bao Yan, Xue–Guang Sun, Peng Hu and Tong-Cun Zhang*. Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway. FEBS J. 2014 Feb;281(3):927-42. . (# Co-first author) (*, corresponding author)  (SCI,3区;IF=4.001)
20.Nan Wang, Rui Zhang, Shui-Jing Wang, Chun-Ling Zhang, Li-Bin Mao,Chun-Yu Zhuang, Yan-Yang Tang, Xue-Gang Luo, Hao Zhou, Tong-Cun Zhang*.Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription actor-A signaling pathway. The International Journal of Biochemistry & Cell Biology. 2013 Jul;45(7):1447-56 (SCI, 2区;收录号175KH;IF=4.125)
21.Nan Wang, Yao Xu, Tao Qin, Feng-Po Wang, Lin-Lin Ma, Xue-Gang Luo, Tong-Cun Zhang*. Myocardin-related transcription factor-A is a key regulator in retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells. Gene.523 (2013): 178-186. (SCI, 3区;收录号164QK;IF=2.196)
22.Lin F, Wang N*, Zhang TC*. The role of endothelial-mesenchymal transition in development and pathological process. IUBMB Life. 2012 Sep;64(9):717-23. (* Corresponding author) (SCI, 3区;收录号993VA;IF=2.789)
23.Nan Wang, Guang-Da Ren, Zhen Zhou, Yao Xu, Tao Qin, Ru-Fa Yu, Tong-Cun Zhang*. Cooperation of myocardin and smad2 in inducing differentiation of mesenchymal stem cells into smooth muscle cells. IUBMB Life. 2012 Apr;64(4):331-9. (SCI, 3区;收录号907OK;IF=2.789)
24.Liao Xing-Hua#, Nan Wang#, Qing-Xi Liu, Tao Qin, Bo Cao, Dong-Sun Cao, Tong-Cun Zhang*. Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy. IUBMB Life. 2011; 1, 63(1): 54-61. (* Co-first author) (SCI, 3区;收录号725WH;IF 2011 = 3.514) 
25.Nan Wang, Zhen Zhou, Xinghua Liao and Tongcun Zhang*,Role of microRNAs in cardiac hypertrophy and heart failure. IUBMB Life, 2009 Jun;61(6):566-71. (SCI,3区;收录号454IU;IF= 3.578)
26.Wang N, Sun C, Huo S, Zhang Y, Zhao J, Zhang S, Miao J. Cooperation of phosphatidylcholine-specific phospholipase C and basic fibroblast growth factor in the neural differentiation of mesenchymal stem cells in vitro. Int J Biochem Cell Biol. 2008; 40(2):294-306. (SCI, 2区, IF= 4.178)  
27.Wang N, Xie K, Huo S, Zhao J, Zhang S, Miao J. Suppressing Phosphatidylcholine-specific Phospholipase C and elevating ROS level, NADPH oxidase activity and Rb level induced neuronal differentiation in mesenchymal stem cells. J Cell Biochem. 2007 Apr 15;100(6):1548-57. (SCI, 3区, IF= 3.54)
28.Wang N, Lv X, Su L, Zhao B, Zhang S, Miao J. D609 blocks cell survival and induces apoptosis in neural stem cells. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4780-3. (SCI, 3区, IF= 2.531) 

29.Wang N, Du CQ, Wang SS, Xie K, Zhang SL, Miao JY. D609 induces vascular endothelial cells and marrow stromal cells differentiation into neuron-like cells. Acta Pharmacol Sin. 2004 Apr;25(4):442-6. (IF= 1.676)


Awards:

In 2011, she instructed undergraduates to participate in the "Challenge Cup" extracurricular academic and technological works competition, and won the "Tianjin First Prize" and the "Excellent Instructor" title; in 2013, she instructed undergraduates to participate in the "Challenge Cup" extracurricular academic and technological works competition, and won the "Tianjin Third Prize"; in 2013, "Advanced Individuals" at the school level; and in 2013, "First Teacher and Student". Advanced Individual in the Activities of Helping One Student; in 2015, Advanced Individual Honour of Tianjin Youth "Innovation, Entrepreneurship and Excellence".


Contacts:
Office address: College of Biotechnology, Tianjin University of Science and Technology, No. 29, 13 Street, Tianjin Economic-Technological Development Area (TEDA), Tianjin.
Zip code: 300457
Office phone: 022-60602099
Fax: 022-60602298
Email: wn929@tust.edu.cn

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