Dr. Zhen Liu, Assistant Professor

Research field

Her research fields focus on the pharmacodynamics, toxicology and pharmacokinetics of antitumor drugs.

[1] The Science Foundation for Post Doctorate Research of China, 2015M570229, 2015-2016, Principal investigator
[2] The National Natural Science Foundation of China, 81703014, 2018/01-2020/12, Principal investigator
[3] Scientific research project of Tianjin Municipal Education Commission, 2017KJ010, 2017/05-2020/04, Principal investigator
[4] The National Natural Science Foundation of China, 81673647, 2017/01-2020/12, CO-PI

[5] The National Natural Science Foundation of China, 31601203, 2017/01-2019/12, CO-PI 

1.Liu Z, Zheng Q, Chen WZ, Wu M, Pan GJ, Yang K, Li XZ, Man SL, Teng YO, Yu P, Gao WY. Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways. European Journal of Medicinal Chemistry, 2017, 125:760-769. 
2.Liu Z, Zheng Q, Chen WZ, Man SL, Teng YO, Meng X, Zhang YM, Yu P, Gao WY. Paris saponin I inhibits proliferation and promotes apoptosis through down-regulating AKT activity in human non-small-cell lung cancer cells and inhibiting ERK expression in human small-cell lung cancer cells. RSC Advances, 2016, 6: 70816-70824. 
3.Teng YO, Wang LX, Liu H, Yuan Y, Zhang Q, Wu M, Wang LY, Wang HM, Liu Z*, Yu P*. 3"-Geranyl-mono-substituted chalcone Xanthoangelovl induces apoptosis in human leukemia K562 cells via activation of mitochondrial pathway. Chemico-Biological Interactions, 2017, 261:103-107.
4.Liu Z, Wang JY, Gao WY, Man SL, Guo HM, Zhang JZ, Liu CX. Formulation and in vitro absorption analysis of Rhizoma paridis steroidal saponins. International Journal of Pharmaceutics, 2013, 441(1-2): 680-686. 
5.Liu Z, Li HF, Fan YY, Liu YX, Man SL, Yu P, Gao WY. Combination treatment with Rhizoma Paridis and Rhizoma Curcuma longa extracts and 10-hydroxycamptothecin enhances the antitumor effect in H22 tumor model by increasing the plasma concentration. Biomedicine & Pharmacotherapy, 2016, 83: 627-634. 
6.Liu Z, Gao WY, Man SL, Zhang Y, Li HF, Wu SS, Zhang JZ, Liu CX. Synergistic effects of Rhizoma Paridis and Rhizoma Curcuma longa on different animal tumor models. Environmental Toxicology and Pharmacology, 2014, 38(1): 31-40. 
7.Liu Z, Gao WY, Jing SS, Zhang Y, Man SL, Wang Y, Zhang JZ, Liu CX. Correlation among cytotoxicity, hemolytic activity and the composition of steroidal saponins from Paris L.. Journal of Ethnopharmacology, 2013, 149(2): 422-430. 
8.Liu Z, Wang JY, Gao WY, Man SL, Wang Y, Liu CX. Preparative separation and purification of steroidal saponins in Paris polyphylla var. yunnanensis by macroporous adsorption resins. Pharmaceutical Biology, 2013, 51(7): 899-905. 
9.Liu Z, Zhang JZ, Gao WY, Liu CX. Antinociceptive activity and Chemical composition of Wei-Chang-An-Wan extracts. Pharmaceutical Biology, 2013, 51: 790-797.
10.Liu Z, Li N, Gao WY, Man SL, Yin SS, Liu CX. Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L.. Journal of Ethnopharmacology, 2012, 142(3): 789-794. 
11.Liu Z, Gao WY, Man SL, Wang JY, Li N, Yin SS, Wu SS., Liu CX. Pharmacological evaluation of sedative-hypnotic activity and gastro-intestinal toxicity of Rhizoma Paridis saponins. Journal of Ethnopharmacology, 2012, 144(1): 67-72.

No.29, 13th Avenue, Tianjin Economic and Technological Development Area, Tianjin 300457, China 
Phone: 022-60912562
Email: liuzhen5957@tust.edu.cn