Associate Professors


Name: Kui Lu                             Degree: Ph.D.                            
Phone: +862260912562                      Email: lukui@tust.edu.cn
Address: Room 607, Yifu Building, Tianjin University of Science & Technology, Tianjin, 300457

September 2002-July 2007: 
Ph.D. in Organic Chemistry in College of Chemistry and Molecular Engineering, Peking University
Advisor: Professor Zhen Yang and Jiahua Chen

September 1998-July 2002: 
B.S. in chemistry, in College of Applied Chemistry, China Agricultural University
Advisor: Professor Daoquan Wang 

Associate Professor, Tianjin University of Science & Technology (December 2012-Present)
Assistant Professor, Tianjin University of Science & Technology (July 2011-November 2012)
Groupleader, Bioduro (Beijing) Co., Lid. (A PPD’s Company) (September 2008-May 2011)
Postdoc, University of California Los Angeles (August 2007-August 2008)

Experiments of Organic Reactions for Drug Synthesis for Undergraduate Students
Drug Design and Synthesis and Modern Organic Synthesis for Graduate Students

Drug synthesis 
Organic synthesis

Second level of 131 talents in Tianjin (2015)
Third level of 131 talents in Tianjin (2013)

[1] Transition-Metal-Free Direct Trifluoromethylthiolation and Trifluoromethylsulfoxidation of Electron-rich Aromatics with CF3SO2Na in the presence of PCl3. Xia Zhao*, Aoqi Wei, Bo Yang, Tianjiao Li, Quan Li, Di Qiu and Kui Lu*, J. Org. Chem., 2017, 82, 9175.
[2] Synthesis and anti-oxidant activity evaluation of (±)-Anastatins A, B and their analogs. Guojun Pan, Xuehui Li, Long Zhao, Meng Wu, Chao Su, Xuzhe Li, Yongmin Zhang, Peng Yu, Yuou Teng* and Kui Lu *, Eur. J. Med. Chem. 2017, 138, 577.
[3] Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5, 6-disubstituted derivatives. Hua Sun, Weina Ding, Xiaotong Song, Dong Wang, Mingzhu Chen, Kaili Wang, Yazhou Zhang, Peng Yuan, Ying Ma, Runling Wang, Robert H. Dodd, Yongmin Zhang, Kui Lu* and Peng Yu*, Bioorg. Med. Lett. 2017, 27, 3226
[4] Transition-metal-free Trifluoromethylthiolation and Difluoromethylthiolation of Thiols with Trifluoromethanesulfonyl Chloride and Difluoromethanesulfonyl Chloride. Xia Zhao,* Tianjiao Li, Bo Yang, Di Qiu and Kui Lu*, Tetrahedron. 2017, 73, 3112.
[5] Total Synthesis of I3,II8-Biapigenin and Ridiculuflavone A. Kui Lu,* Ke Yang, Xiaoliang Jia, Xing Gao, Xia Zhao, Guojun Pan, Yantao Ma, Qiyao Huang and Peng Yu*, Org. Chem. Front, 2017, 4, 578
[6] Transition-Metal Free Direct Difluoromethylthiolation of Electron-Rich Aromatics with Difluoromethanesulfonyl Chloride. Xia Zhao,* Aoqi Wei, Tianjiao Li, Zhiyang Su, Jun Chen, and Kui Lu*, Org. Chem. Front, 2017, 4, 232.
[7] Transition Metal-Free Direct Trifluoromethylthiolation of Indoles using Trifluoromethanesulfonyl Chloride in the Presence of Triphenylphosphine. Kui Lu,* Zhijie Deng, Ming Li, Tianjiao Li and Xia Zhao*, Org. Biomol. Chem. 2017, 15, 1254.
[8] Synthesis and antioxidant evaluation of desmethylxanthohumol analogs and their dimers. Yuou Teng, Xuzhe Li, Ke Yang, Xuehui Li, Zijun Zhang, Luyao Wang, Zhijie Deng, Binbin Song, Zhihong Yan, Yongmin Zhang, Kui Lu,* and Peng Yu*, Eur. J. Med. Chem. 2017, 125, 335
[9] 1,4-Addition Ugi Reaction Using Cyclic α,β-Unsaturated Ketone as Substrate. Kui Lu,* Yantao Ma, Meile Gao, Yan Liu, Ming Li, Chuanming Xu, Xia Zhao,* and Peng Yu*, Org. Lett. 2016, 18, 5038. 
[10] Iodine-catalysed regioselective thiolation of flavonoids using sulfonyl hydrazides as sulfenylation reagents 
Xia Zhao*, Zhijie Deng, Aoqi Wei, Boyang Li and Kui Lu*, Org. Biomol. Chem. 2016, 14, 7304.
[11] Synthesis of Substituted Pyrroles via Copper-catalyzed Cyclization of Ethyl Allenoates with Activated Isocyanides. Kui Lu*, Fang Ding, Long Qin, Xiaoliang Jia, Chuanming Xu, Xia Zhao, Qingwei Yao and Peng Yu*, Chem-Asian. J. 2016, 11, 2121.
[12] Total synthesis of 8-(6″-umbelliferyl)-apigenin and its analogs as anti-diabetic reagents. Guojun Pan, Lianbo Zhao, Na Xiao, Ke Yang, Yantao Ma, Xia Zhao, Zhenchuan Fan, Yongmin Zhang, Qingwei Yao, Kui Lu* and Peng Yu*, Eur. J. Med. Chem. 2016, 122, 674.
[13] Iodine-catalyzed thiolation of electron-rich aromatics using sulfonyl hydrazides as sulfenylation reagents Xia Zhao*, Tianjiao Li, Lipeng Zhang, and Kui Lu*, Org. Biomol. Chem. 2016, 14, 1131.
[14] Potassium iodide promoted thiolation of pyrazolones and benzofurans using aryl sulfonyl chlorides as sulfenylation reagents. Xia Zhao*, Xiaoyu Lu, Aoqi Wei, Xiaoliang Jia, Jun Chen and Kui Lu*, Tetrahedron Lett. 2016, 57, 5330.
[15] Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Hirohito Shimizu†, Johann Schredelseker†, Jie Huang†, Kui Lu†, Shamim Naghdi, Fei Lu, Sarah Franklin, Hannah DG Fiji, Kevin Wang, Huanqi Zhu, Cheng Tian, Billy Lin, Haruko Nakano, Amy Ehrlich, Junichi Nakai, Adam Z Stieg, James K Gimzewski, Atsushi Nakano, Joshua I Goldhaber, Thomas M Vondriska, György Hajnóczky, Ohyun Kwon, Jau-Nian Chen* elife 2015, 4 (†Co-fisrt author)
[16] Synthesis of 6-or 8-Bromo Flavonoids by Regioselective Mono-Bromination and Deprotection Protocol from Flavonoid Alkyl Ethers. Guojun Pan, Ke Yang, Yantao Ma, Xia Zhao, Kui Lu*, Peng Yu* Bull. Korean. Chem. Soc. 2015, 36, 1460.
[17] Total synthesis of (±)-Anastatins A and B. Guojun Pan, Yantao Ma, Ke Yang, Xia Zhao, Hui Yang, Qingwei Yao, Kui Lu*, Tao Zhu*, Peng Yu* Tetrahedron Lett., 2015, 56, 4472-4475.
[18] Synthesis of 2-Aryl and 3-Aryl Benzo[b]furan Thioethers Using Aryl Sulfonyl Hydrazides as Sulfenylation Reagents. Xia Zhao*, Lipeng Zhang, Xiaoyu Lu, Tianjiao Li and Kui Lu*, J. Org. Chem., 2015, 80, 2918-2924.
[19] p-Toluenesulphonic acid-promoted, I2-catalysed sulphenylation of pyrazolones with aryl sulphonyl hydrazides. Xia Zhao*, Lipeng Zhang, Tianjiao Li, Guiyan Liu, Haomeng Wang and Kui Lu*, Chem. Commun., 2014, 50, 13121-13123.
[20] Concise Synthesis of Prenylated and Geranylated Chalcone Natural Products by Regiospecific Iodination and Suzuki Coupling Reactions. Haomeng Wang, Zhihong Yan, Yanan Lei, Kai Sheng Qingwei Yao, Kui Lu* and Peng Yu*, Tetrahedron Lett., 2014, 55, 897-899.
[21] Regioselective Iodination of Flavonoids by N-Iodosuccinimide under Neutral Conditions. Kui Lu, Jie Chu Haomeng Wang, Xiaoli Fu, Dewu Quan, Hongxia Ding, Qingwei Yao and Peng Yu*, Tetrahedron Lett., 2013, 54, 6345-6438.
[22] Development of a Concise and Diversity-Oriented Approach for the Synthesis of Plecomacrolides via the Diene-Ene RCM. Kui Lu, Mengwei Huang, Zheng Xiang, Yongxiang Liu, Jiahua Chen* and Zhen Yang*, Org. Lett., 2006, 8, 1193-1196.
[23] A Concise and Diversity-Oriented Strategy for the Synthesis of Benzofurans and Indoles via Ugi and Diels-Alder Reactions. Kui Lu, Tuoping Luo, Zheng Xiang, Reza Fathi*, Jiahua Chen* and Zhen Yang*, J. Comb. Chem., 2005, 7, 958-967.