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Professors


Fu-Feng Liu

Ph.D., Full Professor,
College of Biotechnology,
Tianjin University of Science & Technology, 
Tianjin 300457, P. R. China.
Tel. +86-22-60602717
Email: Fufengliu@tust.edu.cn

PERSONAL BACKGROUND
Education
1998.09-02.07 Chemistry & Biology College, Yantai University, B.S.
2003.09-05.08 Dept. Chem. Eng., Tianjin University, M.S.
2005.09-08.09 Dept. Chem. Eng., Tianjin University, Ph. D.

Employment
2002.07-2003.08 Technician, Yichang Fine Chemical Factory of Fushan Distict
2008.12-2011.06 Lecturer, Dept. Chem. Eng., Tianjin University.
2011.06-2016.04 Associate professor, Dept. Chem. Eng., Tianjin University.
2013.03-2015.05    Xiangjian Scholar, The Hong Kong Polytechnic University. 
2016.04-2016.11    Associate professor, Tianjin University of Science & Technology.
2016.12-present     Full professor, Tianjin University of Science & Technology.

RESEARCH
Research Area

- Rational design of novel enzyme 
- Amyloid aggregation and its inhibition

Foundings
1.National Natural Science Foundation of China (21878234), 660,000, 2019.01-2022.12
2.Discipline Leading Talent Training Program of college of Tianjin city, 600,000, 2017.09-2020.08
3.Natural Science Foundation of Tianjin from Tianjin Municipal Science and Technology Commission, China (18JCZDJC33000), 200,000, 2018.04-2021.03.
4.Funding of Distinguished Scholar Professor of Tianjin City, 1,000,000 2018.07-2022.06
5.Funding of Haihe River Scholar, 500,000 2016.04-2019.03
6.National Natural Science Foundation of China (21576199), 764,000, 2016.01-2019.12
7.National Natural Science Foundation of China (20906068), 200,000, 2010.01-2012.12.
8.Natural Science Foundation of Tianjin from Tianjin Municipal Science and Technology Commission, China (10JCYBJC04500), 100,000, 2010.04-2013.03.
9.China Postdoctoral Foundation (2013M530115), 80, 000, 2013.03-2015.02.
10.China Postdoctoral Foundation (2012T50241), 100, 000, 2013.03-2015.02.
11.Independent Innovation Foundation of Tianjin University, China, 50,000, 2010.01-2011.12.

Publications
60. Fufeng Liu٭, Wenjuan Wang, Jingcheng Sang, Longgang Jia, Fuping Lu. Hydroxylated Single Wall Carbon Nanotube Inhibits Aβ1-42 Fibrillogenesis, Disaggregates Preformed Fibrils, and Protects against Aβ42-Induced Cytotoxicity. ACS Chemical Neuroscience. In Press.
59. Shuhong Mao#; Jian-Wen Wang#; Fufeng Liu#; Zhangliang Zhu; Dengke Gao; Qianqian Guo; Panpan Xu; Zheng Ma; Yali Hou; Xiaotao Cheng; Dengyue Sun; Fuping Lu* and Hui-Min Qin*. Engineering of 3-ketosteroid-∆1-dehydrogenase based site-directed saturation mutagenesis for efficient biotransformation of steroidal substrates, Microbial Cell Factories, 2018, 17: 141.
58. Yuyuan Zhao; Rong Zhu; Xiyong Song; Zheng Ma; Shengfeng Chen; Dongni Wu; Fufeng Liu; Songying Ouyang; Jianguo Zhang; Seeram Ramakrishna; Xiaofeng Zhu; Liumin He. Assembly pathway selection of designer SAP and fabrication of hierarchical scaffolds for neural regeneration, ACS Appl. Mater. Interfaces. 2018, 10(31): 26128-26141.
57. Yu Li, Xiaoyan Hu, Jingcheng Sang, Ying Zhang, Huitu Zhang, Fuping Lu٭, Fufeng Liu٭. An acid-stable β-glucosidase from Aspergillus aculeatus: Gene expression, biochemical characterization and molecular dynamics simulation, International Journal of Biological Macromolecules, 2018, 119: 462-469. 
56. Junying Wang, Ying Zhang, Xingji Wang, Jinzhao Shang, Yu Li, Huitu Zhang, Fuping Lu,٭ Fufeng Liu٭. Biochemical characterization and molecular mechanism of acid denaturation of a novel α-amylase from Aspergillus niger. Biochemical Engineering Journal, 2018, 137: 222-231.
55. L. Jia, W. Wang, J. Shang, W. Zhao, W., Y. Wang, F. Lu*, F.-F. Liu*. Highly Efficient Soluble Expression, Purification and Characterization of Recombinant Aβ42 from Escherichia coli, RSC Advances, 2018, 8: 18434-18441.
54. N. Lu*, Y. Sun, Y. Ding, R. Tian, L. Li,* F.-F. Liu* Adsorption of human serum albumin on functionalized single-walled carbon nanotubes reduced cytotoxicity. Chemico-Biological Interactions, Doi: 10.1016/j.cbi.2018.03.015.
53. H. Zhang, X. Dong,* F.-F. Liu, J. Zheng, Y. Sun. Ac-LVFFARK-NH2 conjugation to β-cyclodextrin exhibits significantly enhanced performance on inhibiting amyloid β-protein fibrillogenesis and cytotoxicity, Biophysical Chemistry, 2018, 235: 40-47.
52. J. Meng#, H. Zhang#, X. Dong*, F.-F. Liu, Y. Sun*. RTHLVFFARK-NH2: A potent and selective modulator on Cu2+-mediated amyloid-β protein aggregation and cytotoxicity, Journal of Inorganic Biochemistry, 2018, 181: 56-64.

2017
51. H. Qin, Z. Zhu, Z. Ma, P. Xu, Q. Guo, S. Li, J. Wang, S. Mao, F.-F. Liu*, and F.-P. Lu*. Rational design of cholesterol oxidase for efficient bioresolution of cholestane skeleton substrates, Scientific Reports, 2017, 7: 16375. 
50. J. Zhao, F.-F. Liu, C. Huang, J. Shentu, M. Wang, C. Sun, L. Chen, S. Yan, F. Fang, Y. Wang, S. Xu, C. Benjamin Naman, Q. Wang, S. He*, W. Cui*. 5-Hydroxycyclopenicillone inhibits β-amyloid oligomerization and produces anti-β-amyloid neuroprotective effects in vitro, Molecules, 2017, 22(10): E1651.
49. J.-J. Guo#, W.-Q. Sun#, F.-F. Liu*. Brazilin inhibits the Zn2+-mediated aggregation of amyloid β-protein and alleviates cytotoxicity, Journal of Inorganic Biochemistry, 2017, 177: 183-189.
48. J.-J. Guo#, W.-Q. Sun#, L. Li, F.-F. Liu*, W.-Y. Lu*. Brazilin Inhibits Fibrillogenesis of Human Islet Amyloid Polypeptide, Disassembles Mature Fibrils, and Alleviates Cytotoxicity, RSC Advances, 2017, 7: 43491-43501.
47. H. Liu, X.-Y. Dong, F.-F. Liu, J. Zhen, Y. Sun*. Iminodiacetic acid-conjugated nanoparticles as a bifunctional modulator against Zn2+-mediated amyloid β-protein aggregation and cytotoxicity. Journal of colloid and Interface Science, 2017, 505: 973-982.
46. S.-Y. Xiang, F.-F. Liu, J.-J. Lin, C.-H. Huang, L.-P. Chen, C. Wang, S. He, Q.-W. Wang, W. Cui*, J.-R. Zhang*. Fucoxanthin inhibits Aβ assembly and attenuates Aβ oligomers-induced cognitive impairments, J. Agr. Food Chem., 2017, 65(20): 4092-4102.
45. F.-F. Liu, Y.-B. Fan, Z. Liu, S. Bai. Molecular Mechanism Underlying Affinity Interactions between ZAβ3 and the Aβ16-40 Monomer, Acta Phys. Chim. Sin., 2017, 33(9): 1905-1914. 
44. 刘逸寒,王洪彬,刘夫锋,张会图,秦慧民,路福平. 微生物碱性蛋白酶的研究与开发,天津科技大学学报, 2017, 32(2): 1-6.
43. B.-L. Xie, F.-F. Liu, X.-Y. Dong*, Y.-J. Wang, X. M. Liu, Y. Sun*. Modulation Effect of Acidulated Human Serum Albumin on Cu2+-Mediated Amyloid β-Protein Aggregation and Cytotoxicity under a Mildly Acidic Condition. Journal of Inorganic Biochemistry, 2017, 171: 67-75. 
2016. 
42. H.-C. Shen, J.- Y. Ding, L. Li, F.-F. Liu*. Effect of Y220C Mutant on the Conformational Transition of p53C Probed by Molecular Dynamics Simulation. Acta Phys. Chim. Sin. 2016, 32(10): 2620-2627.
41. Y.-L. Tu, S. Ma, F.-F. Liu,* Y. Sun, X.-Y. Dong*. Hematoxylin Suppresses Amyloid β-Protein Aggregation and Reduces Amyloid Cytotoxicity, The Journal of Physical Chemistry B, 120 (44), 11360–11368. 
40. J.- Y. Ding, H.-C. Shen, F.-F. Liu*. Virtual Screening of Small Molecular Stabilizer for Y220C Mutation of p53C. Chem. J. Chinese U. 2016, 37(4): 706-714.
39.  H.-C. Liu, B.-L. Xie, X.-Y. Dong, L. Zhang, Y.-J. Wang, F.-F. Liu, Y. Sun*.  Negatively charged hydrophobic nanoparticles inhibit amyloid β-protein fibrillation: The presence of an optimal charge density. Reactive and Functional Polymers, 2016, 103: 108-116.
38.  S. Li, F.-F. Liu, L.-L. Yu, Y. Sun, X.-Y. Dong, Dual Effect of Thioflavin T on Amyloid β-Protein 1-40 Fibrillization, Acta Phys. Chim. Sin., 2016, 32(6): 1391-1396.
2015. 
37. M-Z Zhang, R-D Hu, H Chen, Y Chang, X Gong, F-F Liu, J Zheng*, Interfacial interaction and lateral association of cross-seeding assemblies between hIAPP and rIAPP oligomers. Physical Chemistry Chemical Physics, 2015, 17 (16): 10373-10382.
36. W-J Du, J-J Guo, M-T Gao, S-Q Hu, X-Y Dong, Y-F Han, F-F Liu*, S-Y Jiang*, Y Sun*: Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity. Scientific Reports, 2015, 7992.
35. N Xiong, X-Y Dong, J Zheng, F-F Liu*, Y Sun*: Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity. ACS Applied Materials & Interfaces, 2015, 7: 5650-5662.
2014
34. F.-F. Liu, W.-J. Du, Y. Sun, J. Zheng*, and X.-Y. Dong*. Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-β protein, Frontiers of Chemical Science and Engineering, 2014, 8: 433-444.
33. W.-W. Zhao, F.-F. Liu, Q.-H. Shi, and Y. Sun*. Octapeptide-based affinity chromatography of human immunoglobulin G: Comparisons of three different ligands, Journal Chromatography A 2014, 1359: 100-111.
32. S. Bai, Y. Chang, X.-J. Liu, F.-F. Liu*. Interactions between trehalose and amino acids by molecular dynamics simulations, Acta Phys. Chim. Sin. 2014, 30(7): 1239-1246.
31. N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Synergistic inhibition of acid-induced protein denaturation by trehalose and NaCl: Thermodynamic and kinetic studies, Biochemical Engineering Journal, 2014, 91: 231-239. SCI: AS0EJ. Oct. 15, 2014
30. W.-W. Zhao, F.-F. Liu*, Q.-H. Shi, X.-Y. Dong, and Y. Sun*. Biomimetic design of affinity peptide ligands for human IgG based on Protein A-IgG complex. Biochemical Engineering Journal, 2014, 88: 1-11.
29. N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Counteraction of Trehalose on Urea-Induced Protein Unfolding: Thermodynamic and Kinetic Studies, Biochemical Engineering Journal, 2013, 79(15): 120-128. Oct 15, 2013
28. S.-Y. Chang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Molecular insight into conformational transmission of human P-glycoprotein, The Journal of Chemical Physics, 2013,139(22): 225102. (Cover page)
27. F.-F. Liu, B. Huang, X.-Y. Dong, and Y. Sun*. Molecular Basis for the Dissociation Dynamics of Protein A-Immunoglobulin G1 Complex. Plos One, 2013, 8(6): e66935.
26. S.-Y. Chang, F.-F. Liu*. Molecular Simulations of ATP-Binding Cassette Transporters, Progress in Chemistry, 2013, 25(7): 1208-1218.
25. S. Bai, R. Zhou, F.-F. Liu*. Rational Design of Affinity Ligand for the Oriented Immobilization of Trypsin, Acta Phys. Chim. Sin. 2013, 29(2): 439-448.
24. N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Equilibrium and kinetic studies of the counteraction of trehalose on acid-induced protein unfolding. Biochemical Engineering Journal, 2013, 70: 188-195.
23. X.-Y. Dong, W.-J. Du, F.-F. Liu*. Molecular Dynamics Simulation and Binding Free Energy Calculation of the Conformational Transition of Amyloid Peptide 42 Inhibited by Peptide Inhibitors, Acta Phys. Chim. Sin. 2012, 28 (11), 2735-2744.
22. 刘夫锋, 孙彦. 配基理性设计技术及其应用进展. 生物产业技术, 2012, 03, 70-74.
21. N. Zhang, F.-F. Liu*, X.-Y. Dong, and Y. Sun*. Molecular Insight into the Counteraction of Trehalose on Urea-Induced Protein Denaturation Using Molecular Dynamics Simulation. The Journal of Physical Chemistry B, 2012, 116: 7040-7047.
20. F.-F. Liu, Z. Liu, S. Bai, X.-Y. Dong, and Y. Sun*. Exploring the inter-molecular interactions in amyloid-β protofibril with molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area free energy calculations. The Journal of Chemical Physics, 2012, Apr 14; 136 (14):145101.
19. S.-H. Wang, F.-F., Liu, X.-Y. Dong, Y. Sun*. Calorimetric and Spectroscopic Studies of the Interactions between Insulin and (-)-Epigallocatechin-3-gallate. Biochemical Engineering Journal, 2012, 62: 70-78.
18. B. Huang, F.-F. Liu*, X.-Y. Dong, Y. Sun*. Molecular Mechanism of the Effects of Salt and pH on the Affinity between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations, The Journal of Physical Chemistry B, 2012, 116, 424-433.
17. Y. Sun*, Q.-H. Shi, L. Zhang, G. Zhao, F. -F. Liu: Adsorption and chromatography. In ed. Comprehensive Biotechnology, Vol. 2, Chapter 2.47. pp. 665-679. Elsevier, 2011.
16.  F. -F. Liu, X. -Y. Dong, L. Z. He, A. P. J. Middelberg, Y. Sun*: Molecular Insight into Conformational Transition of Amyloid β-Peptide 42 Inhibited by (-)-Epigallocatechin-3-gallate Probed by Molecular Simulations. The Journal of Physical Chemistry B, 2011, 115, 11879-11887. 
15.  B. Huang, F.-F. Liu, X.-Y. Dong, Y. Sun*. Molecular Mechanism of the Affinity Interactions between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations. The Journal of Physical Chemistry B, 2011, 115, 4168-4176.
14.  S.-H. Wang, F.-F., Liu, X.-Y. Dong, Y. Sun*. Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Peptide 42 and (-)-Epigallocatechin-3-gallate. The Journal of Physical Chemistry B, 2010, 114: 11576-11583.
13.  F.-F. Liu, L. Ji, X.-Y. Dong*: Effects of molecular volume and fractional polar surface area of osmolytes on the thermal stability of Chymotrypsin inhibitor 2. Acta Phys. Chim. Sin., 2010, 26 (10):2813-2820. 
12. F.-F. Liu, X.-Y. Dong, Y. Sun*: Molecular Dynamics Simulation of the Conformational Transition of Amyloid Peptide 42 Inhibited by Trehalose. Acta Phys. Chim. Sin., 2010, 26(6):1643-1650.
11. F.-F. Liu, J. Luo, L. Zhang, X.-Y. Dong, Y. Sun*: Molecular basis for polyol-induced protein stability revealed by molecular dynamics simulations. Journal of Chemical Physics, 2010, 132: 225103.
10.  F.-F. Liu, J. Luo, X.-Y. Dong, Y. Sun*: BIOT 146-Molecular dynamics simulation of the inhibition effect of trehalose on the nucleation and elongation of amyloid beta-peptide oligomers. Abstracts of papers of the American Chemical Society, Vol: 238, 146-BIOT, Aug 16 2009. 
9.   F.-F. Liu, J. Luo, X.-Y. Dong, Y. Sun*: Molecular insight into the inhibition effect of trehalose on the nucleation and elongation of Amyloid β-peptide oligomers. The Journal of Physical Chemistry B, 2009, 113 (32): 11320-11329.
8. X.-Y. Dong, J.-H. Liu, F.-F. Liu, Y. Sun*: Self-interaction of native and denatured Lysozyme in the presence of osmolytes, L-arginine and guanidine hydrochloride. Biochemical Engineering Journal, 2009, 43: 321-326.
7. Y. Sun*, F.-F. Liu, Q.-H. Shi: Approaches to high-performance preparative chromatography of proteins, Advances in Biochemical Engineering /Biotechnology, 2009, 113: 217-254.
6. F.-F. Liu, X.-Y. Dong, Y. Sun*: Molecular mechanism for the effects of trehalose on β-hairpin folding revealed by molecular dynamics simulation. Journal of Molecular Graphics & Modelling, 2008, 27 (4): 421-429.
5. F.-F. Liu, X.-Y. Dong, Y. Sun*: Discovery and design of affinity ligands for protein chromatography. Journal of Biotechnology, 2008, 136: S497.
4. F.-F. Liu, X.-Y. Dong, T. Wang, Y. Sun*: Rational design of peptide ligand for affinity chromatography of tissue-type plasminogen activator by the combination of docking and molecular dynamics simulations. Journal of Chromatography A, 2007, 1175 (2): 249-258.
3. F.-F. Liu, T. Wang, X.-Y. Dong, Y. Sun*: Rational design of affinity peptide ligand by flexible docking simulation. Journal of Chromatography A, 2007, 1146 (1): 41–50. 
2. W.-H. Wang, Y.-M. Feng, F.-F. Liu, X.-L. Chang, Y. Sun*: Adsorption characteristics of undarria pinnatifida against Ni2+ in aqueous solution. Technology of Water Treatment, 2005, 31 (4): 14-16. (In Chinese)
1.   W.-H. Wang, Y.-M. Feng, F.-F. Liu: Adsorption properties and models of Cd2+ on Ulopteryx Pinnatifida from aqueous solution. Journal of Yantai University (Natural Science and Engineering Edition), 2005, 18 (4): 276-280. (In Chinese)
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