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Associate Professors


HE Hongpeng,phD,Associate Professor

Member of Association of Microbiology, China 


Education and working experience:
2012.7 -,Tianjin University of Science & Technology,College of Biotechnology,Associate Professor. 
2008.5-2011.12,Institute of Molecular and Cell Biology, A-STAR, Singapore, Research Fellow. 
2003.1–2008.5,National University of Singapore,School of Medicine,phD graduate. 
2000.7-2002.12,Tianjin Medical University General Hospital,Resident doctor.  
1997.9–2000.7,Tianjin Medical University,Nuclear Medicine,graduate for Master’s degree.  

1992.9–1997.7,Dalian Medical University,Clinical Medicine,Bachelor.  


Modules:  
Undergraduate:Cell Biology,Technical English 

Graduate: Biopharmaceutical Technology, Advanced Pharmacology


Research fields  
The research of our group mainly focuses on the mechanisms of female cancers such as breast cancer and cervical cancer. We study the roles of deregulated coding or noncoding gene transcription in cancer biology with molecular and epigenetic methods. Also, we study the anticancer activities of small chemical compounds and explore the underlying mechanisms. The effects of microorganisms like lactic acid bacteria on the proliferation and death of cancer cells and the epigenetic mechanisms are also in the scope of our research. 
In details, our research directions include: 
[1] The transcriptional regulation of HPV genes in cervical cancer cells. 
[2] The interactions between HVP proteins and the host cells. 
[3] The biology of non-coding lncRNA in cancer cells. 
 [4] The functions of MRTF-A in breast cancer metastasis. 

[5] The anticancer potentials of small chemical compounds and the mechanisms. 


Funding:  
 [1] National Natural Science Foundation of China, No. 31301073, ‘the epigenetic regulation of HPV E6/E7 gene transcription in HeLa cells’,Start from 2014 Jan to 2016 Dec. 

[2] Applied Basic Science and Frontier Technology Program of Tianjin, No. 13JCYBJC38000, ‘the regulation of cervical cancer associated high risk HPV E6/E7 genes’, Start from 2013 Oct to 2016 Sept. 


Representative publications:  
1.He Hongpeng, Wei Z, Du F, Meng C, Zheng D, Lai Y, Yao H, Zhou H, Wang N, Luo XG, Ma W, Zhang TC. Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells. Cell Signal. 2017 Feb;31:87-95.
2.He Hongpeng, Lai Yongwei, Hao Yunpeng, Liu Yupeng, Zhang Zijiang, Liu Xiang, Guo Chenhong, Zhang Mengmeng, Zhou Hao, Wang Nan, Luo Xue-Gang, Huo Lihong, Ma Wenjian, Zhang Tong-Cun. Selective p300 inhibitor C646 inhibited HPV E6-E7 genes, altered glucose metabolism and induced apoptosis in Cervical Cancer cells. Eur J Pharmacol. 2017 Oct 5;812:206-215. 
3.He Hongpeng, Du Fu, He Yongping, Wei Zhaoqiang, Meng Chao, Xu Yuexin, Zhou Hao, Wang Nan, Luo Xue-Gang, Ma Wenjian, Zhang Tong-Cun. The Wnt-β-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells. Oncotarget. 2018 Jan 4;9(20):15239-15251
4.Meng Chao, He Yongping, Wei Zhaoqiang, Lu Yulin, Du Fu, Ou Guofang, Wang Nan, Luo Xue-Gang, Ma Wenjian, Zhang Tong-Cun, He Hongpeng*. MRTF-A mediates the activation of COL1A1 expression stimulated by multiple signaling pathways in human breast cancer cells. Biomed Pharmacother. 2018 Aug;104:718-728. 
5.Hongpeng HE, Fa-Xing YU, Chi SUN, Yan LUO. CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes. PLoS One. 2011; 6(7):e22088. Epub 2011 Jul 15.
6.Hongpeng HE* and Yan LUO*. Brg1 regulates the transcription of human papillomavirus type 18 E6 and E7 genes. Cell Cycle. 2012 Feb 1;11(3).
7.Hongpeng HE, Mei-Chin LEE, Li-Ling ZHENG, Lei ZHENG, Yan LUO*. Integration of the Metabolic/Redox State, Histone Gene Switching, DNA Replication and S-phase Progression by Moonlighting Metabolic Enzymes. Biosci Rep. 2013 33(2)
8.He Hongpeng, Liu X, Wang D, Wang Y, Liu L, Zhou H, Luo X, Wang N, Ji B, Luo Y, Zhang T. SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells. Gene. 2014 Oct 6. v553 (2014) p98–104.
9.He Hongpeng, Wang D, Yao H, Wei Z, Lai Y, Hu J, Liu X, Wang Y, Zhou H, Wang N, Luo XG, Zhang TC. Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells. Biochem Biophys Res Commun. 2015 Oct 19.v467:813-820.
10.Xing-Hua Liao(#),Li Zheng(#),Hong-Peng He(#),De-Liang Zheng,Zhao-Qiang Wei,Nan Wang,Jian Dong,Wen-Jian Ma,Tong-Cun Zhang,STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells,Cellular Signalling,2015,27(11):2285-2295.
11.Zhang, Rui(#),Wang, Nan,Zhang, Man,Zhang, Li-Nan,Guo, Zhi-Xia,Luo, Xue-Gang,Zhou, Hao,He, Hong-Peng,Zhang, Tong-Cun,Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells.,Stem Cells Int,2015,2015:534758-534758.

12.Li Man(#), He Hong-Peng(#), Gong Hui-Qin, Zhang Jian, Ma Wen-Jian, Zhou Hao, Cao Dong-Sun, Wang Nan, Zhang Tong-Cun. NFATc4 and myocardin synergistically up-regulate the expression of LTCC α1C in ET-1-induced cardiomyocyte hypertrophy. Life Sci. 2016 Jun 15;155:11-20.


Contacting information:  
Address:Building 13, room 408, The 13th Avenue No. 29, TEDA Tianjin, China 
Post code:300457 
Tel:022-60602099 
Fax:022-60602298 
Email: hehongpeng@tust.edu.cn
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