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Associate Professors


PERSONAL INFORMATION

Shen Yanbing, Ph.D, Associate professor, College of Biotechnology, Tianjin University of Science and Technology, Master Supervisor


COURSES OFFERED:
Biopharmaceutical Technology; Principle of Biopharmaceutical Synthesis.

RESEARCH INTERESTS:
The screening and improvement of industrial microorganisms with important values in pharmacy industry;The biocatalysis reactions and the process control using the whole microbial cells as catalysts.

PUBLICATIONS:
More than 30 papers were published in international journals, in addition 20s patent applications. The major papers were as follows:
[1] Shen YB, Niu LL, Yu ZQ, Wang M*, Shang ZH, Yang Y. Sodium alginate-grafted β-cyclodextrins as a matrix for immobilized Arthrobacter simplex for cortisone acetate biotransformation, Applied Surface Science, 2018,444:42-47.
[2] Liu JJ, Wang LF, Shen YB*, Su LQ, Wang M*. Effect of β-cyclodextrins Derivatives on Steroids Biotransformation by Arthrobacter simplex, Applied Biochemistry and Biotechnology, 2018, 185(4), 1004-1013.
[3] Su LQ, Shen YB*, Xia ML, Shang ZH, Xu SP, An XJ, Wang M*. Overexpression of cytochrome p450 125 in Mycobacterium: a rational strategy in the promotion of phytosterols biotransformation, Journal of Industrial Microbiology and Biotechnology, 2018, 45(10): 857-86.
[4] Su LQ, Shen YB*, Zhang WK, Gao T, Shang ZH, Wang M*. Cofactor engineering to regulate NAD+/NADH ratio with its application to phytosterols biotransformation[J]. Microbial Cell Factories, 2017, 16(1):182.
[5] Shen YB, Yu ZQ, Yang X, Wang F, Wang M*. A new technique for promoting cyclic utilization of cyclodextrins in biotransformation, Journal of Industrial Microbiology and Biotechnology, 2017,44(1):1-7.  
[6] Wang LF, Shen YB, Liu MJ, Tang R, Wang M*. Influence of imidazolium-based ionic liquids on the steroid biotransformation by Arthrobacter simplex[J]. Journal of Chemical Technology & Biotechnology, 2018,93(2):426-431.
[7] Qin N, Shen YB*, Yang X, Su LQ, Tang R, Li W, Wang M*. Site-directed mutagenesis under the direction of in-silico protein docking modeling reveals the active site residues of 3-ketosteroid-Δ1-dehydrogenase from Mycobacterium neoaurum, World Journal of Microbiology and Biotechnology, 2017,33:146.
[8] Su LQ , Shen YB*, Gao T, Luo JM, Wang M*. Improvement of AD biosynthesis and cofactors analysis response to enhanced oxygen transfer by oxygen vectors in Mycobacterium neoaurum TCCC11979, Applied Biochemistry and Biotechnology, 2017,182:1564-1574.
[9] Qiao YQ, Shen YB*, Huang W, Wang YP, Ren JJ, Xia T, Wang M. Biocatalyst-mediated production of 11α, 15α-dihydroxy derivatives of androst-1, 4-dien-3, 17-dione, Journal of Bioscience and Bioengineering, 2017,123(6):692-697.
[10] Tang R, Shen YB, Wang M*, Zhai Y, Gao Q. Highly chemoselective and efficient production of 2,6-difluorobenzamide using Rhodococcus ruber CGMCC3090 resting cells.[J]. Journal of Bioscience & Bioengineering, 2017,124 (6): 641-646.
[11] Shen YB, Wang LF, Liang JT, Tang R, Wang M*. Effects of two kinds of imidazolium-based ionic liquids on the characteristics of steroid-transformation Arthrobacter simplex[J]. Microbial Cell Factories, 2016, 15:118. 
[12] Shen YB, Wang F, Wang YP, Zhao Q, Wang M*. Cyclic utilization of HP-b-CD in the bioconversion of cortisone acetate by Arthrobacter simplex[J]. Biotechnol Lett, 2016, 38: 597-602. 
[13] Liu Y, Shen YB*, Qiao YQ, Su LQ, Li C, Wang M*. The effect of 3-ketosteroid-Δ1-dehydrogenase isoenzymes on the transformation of AD to 9α-OH-AD by Rhodococcus rhodochrous DSM43269[J]. Journal of Industrial Microbiology and Biotechnology, 2016, 43: 1303-1311. 
[14] Liu Y, Cao F, Xiong H, Shen YB, Wang M*. Application of 2,4-Dinitrophenyl-hydrazine(DNPH) in High-Throughput Screening for Microorganism Mutants Accumulating 9α-Hydroxyandrost-4-ene-3,17-dione (9α-OHAD)[J]. PLOS ONE, 2016, 10(11).
[15] Shen YB, Liang JT, Li HN, Wang M*. Hydroxypropyl-β-cyclodextrin-mediated alterations in cell permeability, lipid and protein profiles of steroid-transforming Arthrobacter simplex[J]. Applied Microbiology and Biotechnology, 2015, 99(1): 387-397.
[16] Xie RL, Shen YB, Qin N, Wang YB, Su LQ, Wang M*. Genetic differences in ksdD influence on the ADD/AD ratio of Mycobacterium neoaurum[J]. Journal of Industrial Microbiology and Biotechnology, 2015, 42: 507-513.
[17] Chen X, Shen YB, Liang QK, Flavell R, Hong ZY, Yin ZN, Wang M*. Effect of Bavachinin and its derivatives on T cell differentiation[J]. International Immunopharmacology, 2014, 19(2): 399-404.
[18] Luo JM, Liang QK, Shen YB, Chen X, Yin ZN, Wang M*. Biotransformation of bavachinin by three fungal cell cultures[J]. Journal of Bioscience and Bioengineering, 2014, 117(2): 191-196.
[19] Shen YB, Wang M*, Li XD, Zhang JL, Sun H, Luo JM. Highly efficient synthesis of 5-cyanovaleramide by Rhodococcus ruber CGMCC3090 resting cells. Journal of Chemical Technology and Biotechnology. 2012, 87: 1396-1400. 
[20] Shen YB, Wang M*, Li HN, Wang YB, Luo JM. Influence of hydroxypropyl-β-cyclodextrin on phytosterol biotransformation by different strains of Mycobacterium neoaurum. Journal of Industrial Microbiology and Biotechnology. 2012, 39(9), 1253-1259.
[21] Cui LY, Shen YB, Guo XD,Wang YZ, Luo JM, Wang M*.Effects of HP-β-CD on growth and morphology of Absidia coerulea. World Journal of Microbiology and Biotechnology, 2012, 28(8):2723-2729.
[22] Shen YB, Wang M*, Zhang LT , Ma YH, Ma B , Zheng Y , Liu H, Luo JM. Effects of hydroxypropyl-β-cyclodextrin on cell growth, activity, and integrity of steroid-transforming Arthrobacter simplex and Mycobacterium sp. Applied Microbiology and Biotechnology , 2011,90(6): 1995-2003.

CONTACT
Address: College of Bioengineering, Tianjin University of Science and Technology No. 29, St. No. 13 Tianjin Econmic-Technological Development Area (TEDA), Tianjin 300457, P. R. China 
Tel (Office): +86 22 60601256
Fax: +86 22 60602298
E-mail: shenyb@tust.edu.cn

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