Associate Professors


Shen Yanbing, Ph.D, Associate professor, College of Biotechnology, Tianjin University of Science and Technology, Master Supervisor

Biopharmaceutical Technology; Principle of Biopharmaceutical Synthesis.

The screening and improvement of industrial microorganisms with important values in pharmacy industry;The biocatalysis reactions and the process control using the whole microbial cells as catalysts.

More than 30 papers were published in international journals, in addition 20s patent applications. The major papers were as follows:
[1] Shen YB, Niu LL, Yu ZQ, Wang M*, Shang ZH, Yang Y. Sodium alginate-grafted β-cyclodextrins as a matrix for immobilized Arthrobacter simplex for cortisone acetate biotransformation, Applied Surface Science, 2018,444:42-47.
[2] Liu JJ, Wang LF, Shen YB*, Su LQ, Wang M*. Effect of β-cyclodextrins Derivatives on Steroids Biotransformation by Arthrobacter simplex, Applied Biochemistry and Biotechnology, 2018, 185(4), 1004-1013.
[3] Su LQ, Shen YB*, Xia ML, Shang ZH, Xu SP, An XJ, Wang M*. Overexpression of cytochrome p450 125 in Mycobacterium: a rational strategy in the promotion of phytosterols biotransformation, Journal of Industrial Microbiology and Biotechnology, 2018, 45(10): 857-86.
[4] Su LQ, Shen YB*, Zhang WK, Gao T, Shang ZH, Wang M*. Cofactor engineering to regulate NAD+/NADH ratio with its application to phytosterols biotransformation[J]. Microbial Cell Factories, 2017, 16(1):182.
[5] Shen YB, Yu ZQ, Yang X, Wang F, Wang M*. A new technique for promoting cyclic utilization of cyclodextrins in biotransformation, Journal of Industrial Microbiology and Biotechnology, 2017,44(1):1-7.  
[6] Wang LF, Shen YB, Liu MJ, Tang R, Wang M*. Influence of imidazolium-based ionic liquids on the steroid biotransformation by Arthrobacter simplex[J]. Journal of Chemical Technology & Biotechnology, 2018,93(2):426-431.
[7] Qin N, Shen YB*, Yang X, Su LQ, Tang R, Li W, Wang M*. Site-directed mutagenesis under the direction of in-silico protein docking modeling reveals the active site residues of 3-ketosteroid-Δ1-dehydrogenase from Mycobacterium neoaurum, World Journal of Microbiology and Biotechnology, 2017,33:146.
[8] Su LQ , Shen YB*, Gao T, Luo JM, Wang M*. Improvement of AD biosynthesis and cofactors analysis response to enhanced oxygen transfer by oxygen vectors in Mycobacterium neoaurum TCCC11979, Applied Biochemistry and Biotechnology, 2017,182:1564-1574.
[9] Qiao YQ, Shen YB*, Huang W, Wang YP, Ren JJ, Xia T, Wang M. Biocatalyst-mediated production of 11α, 15α-dihydroxy derivatives of androst-1, 4-dien-3, 17-dione, Journal of Bioscience and Bioengineering, 2017,123(6):692-697.
[10] Tang R, Shen YB, Wang M*, Zhai Y, Gao Q. Highly chemoselective and efficient production of 2,6-difluorobenzamide using Rhodococcus ruber CGMCC3090 resting cells.[J]. Journal of Bioscience & Bioengineering, 2017,124 (6): 641-646.
[11] Shen YB, Wang LF, Liang JT, Tang R, Wang M*. Effects of two kinds of imidazolium-based ionic liquids on the characteristics of steroid-transformation Arthrobacter simplex[J]. Microbial Cell Factories, 2016, 15:118. 
[12] Shen YB, Wang F, Wang YP, Zhao Q, Wang M*. Cyclic utilization of HP-b-CD in the bioconversion of cortisone acetate by Arthrobacter simplex[J]. Biotechnol Lett, 2016, 38: 597-602. 
[13] Liu Y, Shen YB*, Qiao YQ, Su LQ, Li C, Wang M*. The effect of 3-ketosteroid-Δ1-dehydrogenase isoenzymes on the transformation of AD to 9α-OH-AD by Rhodococcus rhodochrous DSM43269[J]. Journal of Industrial Microbiology and Biotechnology, 2016, 43: 1303-1311. 
[14] Liu Y, Cao F, Xiong H, Shen YB, Wang M*. Application of 2,4-Dinitrophenyl-hydrazine(DNPH) in High-Throughput Screening for Microorganism Mutants Accumulating 9α-Hydroxyandrost-4-ene-3,17-dione (9α-OHAD)[J]. PLOS ONE, 2016, 10(11).
[15] Shen YB, Liang JT, Li HN, Wang M*. Hydroxypropyl-β-cyclodextrin-mediated alterations in cell permeability, lipid and protein profiles of steroid-transforming Arthrobacter simplex[J]. Applied Microbiology and Biotechnology, 2015, 99(1): 387-397.
[16] Xie RL, Shen YB, Qin N, Wang YB, Su LQ, Wang M*. Genetic differences in ksdD influence on the ADD/AD ratio of Mycobacterium neoaurum[J]. Journal of Industrial Microbiology and Biotechnology, 2015, 42: 507-513.
[17] Chen X, Shen YB, Liang QK, Flavell R, Hong ZY, Yin ZN, Wang M*. Effect of Bavachinin and its derivatives on T cell differentiation[J]. International Immunopharmacology, 2014, 19(2): 399-404.
[18] Luo JM, Liang QK, Shen YB, Chen X, Yin ZN, Wang M*. Biotransformation of bavachinin by three fungal cell cultures[J]. Journal of Bioscience and Bioengineering, 2014, 117(2): 191-196.
[19] Shen YB, Wang M*, Li XD, Zhang JL, Sun H, Luo JM. Highly efficient synthesis of 5-cyanovaleramide by Rhodococcus ruber CGMCC3090 resting cells. Journal of Chemical Technology and Biotechnology. 2012, 87: 1396-1400. 
[20] Shen YB, Wang M*, Li HN, Wang YB, Luo JM. Influence of hydroxypropyl-β-cyclodextrin on phytosterol biotransformation by different strains of Mycobacterium neoaurum. Journal of Industrial Microbiology and Biotechnology. 2012, 39(9), 1253-1259.
[21] Cui LY, Shen YB, Guo XD,Wang YZ, Luo JM, Wang M*.Effects of HP-β-CD on growth and morphology of Absidia coerulea. World Journal of Microbiology and Biotechnology, 2012, 28(8):2723-2729.
[22] Shen YB, Wang M*, Zhang LT , Ma YH, Ma B , Zheng Y , Liu H, Luo JM. Effects of hydroxypropyl-β-cyclodextrin on cell growth, activity, and integrity of steroid-transforming Arthrobacter simplex and Mycobacterium sp. Applied Microbiology and Biotechnology , 2011,90(6): 1995-2003.

Address: College of Bioengineering, Tianjin University of Science and Technology No. 29, St. No. 13 Tianjin Econmic-Technological Development Area (TEDA), Tianjin 300457, P. R. China 
Tel (Office): +86 22 60601256
Fax: +86 22 60602298
E-mail: shenyb@tust.edu.cn