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Associate Professors


Shuhong Mao

Associate Professor,
Key Laboratory of Industrial Fermentation Microbiology,   Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, No.29, 13th Avenue, TEDA, Tianjin 300457, People’s Republic of China                                                     
EDUCATION 
PhD: Institute of Modern Physics, Chinese Academic of Science, China June, 2006

ESEARCH INTERESTS
Enzyme or immobilization
bioprocess development 
biocatalysis and biotransformation

RESEARCH EXPERIENCE
Associate professor: College of Biotechnology, Tianjin University of Science and Technology, Tianjin, P.R. China, (2006-present) 

Visiting Scholar: Center for Biotechnology and Interdisciplinary Studies(CBIS),  Rensselaer Polytechnic Institute (RPI), Troy, NY. (2015.9-2016.9)


Steroid biotransformation: 
Screening of the strains with high efficient activity in Steroid biotransformation; 
Ionic liquid /water biphasic system for steroid biotransformation;
Bioconversion of monosaccharides and disaccharides into aldonic acids: 
Screening of the strains with high efficiency in aldonic acids production;
Immobilization of the enzyme for efficient aldonic acids production; 

Major Research Projects: 
Study on the construction of ionic liquid/ water biphasic system for steroid biotransformation, Natural Science Foundation of China, (No. 21206127)           
15α Hydroxylation of 18-methyl-estr-4-ene-3, 17-dione by Penicillium raistrickii in Ionic Liquid/Water Biphasic System. Applied Basic Research Programs of Science and Technology Commission Foundation of Tianjin,  (No.12JCQNJC06400)   

 Study on the efficient whole cell biotransformation of steroids 1-en-dehydrogenation by Arthrobacter simplex in deep eutectic solvents containing system, Natural Science Foundation of China, (No. 21878233)


PAPERS
1. Shuhong Mao, Qianqian Guo, Panpan Xu, Dengge Gao, Xiaotao Cheng, Menglu Zhu, Dengyue Sun, Zhangliang Zhu, Fuping Lu(*) and Huimin Qin(*), Biochemical and structural characterization of 3-ketosteroid- Delta 1-dehydrogenase, a candidate enzyme for efficient bioconversion of steroids, Journal of Chemical Technology and Biotechnology, 2018 DOI: 10.1002/jctb.5780.
2. Shuhong Mao, Jian-Wen Wang, Fufeng Liu, Zhangliang Zhu, Dengke Gao, Qianqian Guo, Panpan Xu, Zheng Ma, Yali Hou, Xiaotao Cheng, Dengyue Sun, Fuping Lu(*), and Hui-Min Qin(*), Engineering of 3-ketosteroid-Delta(1)-dehydrogenase based site-directed saturation mutagenesis for efficient biotransformation of steroidal substrates, Microbial Cell Factories, 2018, 17:141. 
3. Mao Shuhong; Li Kang; Hou Yali; Liu Yanna; Ji Shaoxian; Qin Huimin,  Lu Fuping(*), Synergistic effects of components in deep eutectic solvents relieve toxicity and improve the performance of steroid biotransformation catalyzed by Arthrobacter simplex, Journal of Chemical Technology and Biotechnology, 2018, 93(9): 2729-2736. 
4. Shuhong Mao, Xuerong Wang, Zhijiang Ge, An Su, Lixia Zhang, Yanqing Li, Fuping Lu(*), Microbial hydroxylation of 16α, 17α-epoxyprogesterone by Penicillium decumbens. Iranian Journal of Pharmaceutical Research, 2017, 16: 1161-1166.
5. Shuhong Mao,Lixia Zhang,Zhijiang Ge,Xuerong Wang,Yanqing Li,Xiaoguang Liu,Fei Liu,Fuping Lu(*),Microbial hydroxylation of steroids by Penicillium decumbens, Journal of Molecular Catalysis B: Enzymatic, 2016, 133(SI): S346~S351.
6.Shuhong Mao, Lu Yu, Shaoxian Ji, Xiaoguang Liu, Fuping Lu(*), Evaluation of deep eutectic solvents as co-solvent for steroids 1-en-dehydrogenation biotransformation by Arthrobacter simplex, Journal of Chemical Technology and Biotechnology,2016,91(4):1099-1104.
7. Bio-production of L-rhamnonate by Pseudomonas taetrolens, Advances in Applied Biotechnology, 2018, 444: 615-621
8. Huitu Zhang,Yao Tian,Jianling Wang,Yonghai Li,Haikuan Wang,Shuhong Mao,Xiaoguang Liu,Chunxia Wang,Songtao Bie,Fuping Lu,Construction of engineered Arthrobacter simplex with improved performance for cortisone acetate biotransformation,Applied Microbiology and Biotechnology,2013,97(21):9503-9514.
9. Shuhong Mao,Boyuan Hua,Na Wang,Xiaojie Hu,Zhijiang Ge,Yanqing Li,Sha Liu,Fuping Lu(*),11 alpha hydroxylation of 16 alpha, 17-epoxyprogesterone in biphasic ionic liquid/water system by Aspergillus ochraceus,Journal of Chemical Technology and Biotechnology,2013,88(2):287-292.
10. Shuhong Mao,Xiaojie Hu,Boyuan Hua,Na Wang,Xiaoguang Liu,Fuping Lu(*),15 alpha-Hydroxylation of a steroid (13-ethyl-gon-4-en-3,17-dione) by Penicillium raistrickii in an ionic liquid/aqueous biphasic system,Biotechnology Letters,2012,34(11):2113-2117.
11. Shuhong Mao,Kai Liu,Fuping Lu(*),Lianxiang Du. Colorimetric sensors based on hydrogen-bond-induced pi-delocalization and/or anion-triggered deprotonation,Mini-Reviews in Organic Chemistry,2010,7(3):221-229.
12. Shuhong Mao,Na Wang,Zhijiang Ge,Boyuan Hua,Yanqing Li,Fuping Lu(*),Using water miscible ionic liquid to improve the efficiency of 15-hydroxylation of 13-ethyl-gon-4-en-3,17-dione by Penicillium raistrickii,Proceedings of the 2012 International Conference on Applied Biotechnology, ICAB 2012,2012.10.18-2012.10.19.
13. Linlin Huang,Xiaoguang Liu,Yulan He,Pingping Wei,Shuhong Mao,Fuping Lu(*),Screening for Strains Capable of 13β-ethyl-4-gonene-3, 17-dione biotransformation and identication of product,2014 International Conference on Applied Biotechnology, ICAB 2014,597-606.
14. Lu Yu,Shuhong Mao,Shaoxian Ji,Xiaoguang Liu,Fuping Lu(*),Reduction reaction of methyl condensation compound by Saccharomyces cerevisia,2014 International Conference on Applied Biotechnology, ICAB 2014,343-348. 
15. Shuhong Mao Genming Jin, Zengquan Wei, Hongmei Xie, Investigation on the properties of group II introns for potential gene therapy, 2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008, 347-348.

Tel.: +86-22-60601958            Fax: +86-22-60602298
E-mail: shuhongmao@tust.edu.cn
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