Ning Chen

TITLE: Professor, College of Biotechnology, Tianjin University of Science and Technology
Director, National and Local United Engineering Lab of Metabolic Control Fermentation Technology

Director, Tianjin Engineering Lab of Efficient and Green Amino Acid Manufacture

Technical Director, Chinese Amino acid technology service center
Vice chairman, Amino Acid Branch of China Biotech Fermentation Industry Association 
Vice chairman, Fermentation Engineering Committee of China Food Industry Association
Vice chairman, Tianjin Society for Microbiology; Trustee, Chinese Society for Microbiology

Standing director, Journal of Chinese Biotechnology; Letters in Biotechnology; Bulletin of Fermentation Science and Technology

Research interest is mainly on Fermentation Engineering including strain breeding and construction, fermentation process optimization and industrialization for production of amino acids and nucleotides. Another research field is Metabolic Engineering including Quantitative analysis of metabolic network and metabolic control fermentation. 

Presided over more than 30 national and provincial projects, published more than 100 research papers, applied for more than 40 national invention patents, participated in the formulation of more than 10 national and industry standards, and published 9 books.

1.Ning Y, Wu X, Zhang C, Xu Q, Chen N*, Xie X. Pathway construction and metabolic engineering for fermentative production of ectoine in Escherichia coli. Metab Eng, 2016, 36:10-18.  IF: 8.201
2.Wu H, Li Y, Ma Q, Li Q, Jia Z, Yang B, Xu Q, Fan X, Zhang C, Chen N*, Xie X. Metabolic engineering of Escherichia coli for high-yield uridine production. Metab Eng, 2018, 49:248-256.  IF: 8.201
3.Zhang C, Li Y, Ma J, Liu Y, He J, Li Y, Zhu F, Meng J, Zhan J, Li Z, Zhao L, Ma Q, Fan X, Xu Q, Xie X, Chen N*. High production of 4-hydroxyisoleucine in Corynebacterium glutamicum by multistep metabolic engineering. Metab Eng, 2018, 49:287-298.  IF: 8.201
4.Fan X, Wu H, Jia Z, Li G, Li Q, Chen N, Xie X*. Metabolic engineering of Bacillus subtilis for the co-production of uridine and acetoin. Appl Microbiol Biotechnol, 2018, 102(20):8753-8762.  IF: 3.340
5.Zhang C, Qi J, Li Y, Fan X, Xu Q, Chen N*, Xie X. Production of α-ketobutyrate using engineered Escherichia coli via temperature shift. Biotechnol Bioeng, 2016, 113(9):2054-9.  IF: 4.126
6.Li Y, Wei H, Wang T, Xu Q, Zhang C, Fan X, Ma Q, Chen N, Xie X*. Current status on metabolic engineering for the production of l-aspartate family amino acids and derivatives. Bioresour Technol, 2017, 245:1588-1602.  IF: 5.651
7.Fan X, Wu H, Li G, Yuan H, Zhang H, Li Y, Xie X, Chen N*. Improvement of uridine production of Bacillus subtilis by atmospheric and room temperature plasma mutagenesis and high-throughput screening. PLoS One, 2017, 12(5):e0176545.  IF: 3.234
8.Gui Y, Ma Y, Xu Q, Zhang C, Xie X, Chen N*. Complete genome sequence of Corynebacterium glutamicum CP, a Chinese l-leucine producing strain. J Biotechnol, 2016, 220:64-65.  IF: 2.871
9.Xie X, Liang Y, Liu H, Liu Y, Xu Q, Zhang C, Chen N*. Modification of glycolysis and its effect on the production of L-threonine in Escherichia coli. J Ind Microbiol Biotechnol, 2014, 41:1007-1015.  IF: 2.439
10.Liu Q, Cheng Y, Xie X, Xu Q, Chen N*. Modification of tryptophan transport system and its impact on production of L-tryptophan in Escherichia coli. Bioresour Technol. 2012, 114:549-554.  IF: 4.75
11.Xie X, Huo W, Xia J, Xu Q, Chen N*. Structure-activity relationship of a cold-adapted purine nucleoside phosphorylase by site-directed mutagenesis. Enzyme Microb Technol. 2012, 51(1):59-65.  IF: 2.592
12.Xie X, Xu L, Shi J, Xu Q, Chen N*. Effect of transport proteins on L-isoleucine production with the L-isoleucine-producing strain Corynebacterium glutamicum YILW. J Ind Microbiol Biotechnol. 2012, 39(10): 1549-1556.  IF: 2.321

13.Shen T, Liu Q, Xie X, Xu Q, Chen N*. Improved production of tryptophan in genetically engineered Escherichia coli with TktA and PpsA overexpression. J Biomed Biotechnol. 2012, 2012:605219.  IF: 2.88

Authorized Patents:
1.A Corynebacterium glutamicum strain and the method for fermentative production of α-ketoglutarate by using this strain. ZL201110392778.8.
2.Production technology of antiviral agent ribavirin with its precursor addition by fermentation of Bacillus amyloliquefaciens. ZL201310097836.3.
3.Production of 5’ inosinic acid by recombinant expression of ribose phosphate transferase. ZL201410032597.8.
4.Separation and extraction of branched chain amino acids from fermentation broth by two stage membrane continuous crystallization process. ZL201510880406.8.
5.A genetic engineered α-ketoglutarate producing strain and its application. ZL201410132996.1.

6.An L-isoleucine hydroxylase encoding gene, its genetic engineering strain and application. ZL201410132444.0.

Amino Acid Fermentology, Editor, China Light Industry Press, 2007.

Enzyme Engineering, Editor, China Light Industry Press, 2005.

1."Key Technologies of Metabolic Regulation of Temperature Sensitive Glutamate Producing Mutants and Industrialization", Outstanding Award for Scientific and Technological Progress, China General Chamber of Commerce, 2017.
2.“Key Technology of Betaine Improving Production of Amino Acids and Industrialization”, First Award for Scientific and Technological Progress, China Light Industry Council, 2017.
3.“Key Technologies and Industrialization of High Efficiency and Clean Production of Glutamate from Corn”, First Award for Scientific and Technological Progress, Heilongjiang Province, 2017.
4.“Research and Industrialization of Key Technologies for Production of Aromatic Amino Acids and derivatives”, First Award for Scientific and Technological Progress, China Light Industry Council, 2015.
5.“Research and Development of New Technology for Extracting Threonine by Membrane Filtration”, Third Award for Scientific and Technological Progress, The Inner Mongolia Autonomous Region, 2015.
6.“Metabolic Regulation Technology and Industrialization of Branched Chain Amino Acids”, Second Award for Scientific and Technological Progress, Tianjin Municipality, 2013.
7.Honor of Outstanding Science and Technology Worker in Tianjin, 2014.
8.Honor of Outstanding Communist of Tianjin Municipal Education Commission, 2012.

9.Honor of Tianjin May 1 Labor Medal Award, 2009.

Contact Information:
Address:No. 29, 13th Avenue, TEDA, Tianjin 300457, P. R. China
Tel: +86-(0)22-60601251
Fax: +86-(0)22-60602298
Email: ningch@tust.edu.cn