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Associate Professors


Han Pei-pei, Ph.D, Associate Professor.


Teaching
Undergraduate course: Enzyme engineering

Postgraduate course: Synthetic biology


Research Interests
1.Fermentation production of natural food ingredients.
2.Biosynthesis and regulation of microbial active polysaccharides.

3. Cultivation of microalgae and development of active substances.


Current Research Projects
1. National Natural Science Foundation of China Projects: The study on the regulation mechanism of Nostoc flagelliforme polysaccharide biosynthesis during liquid fermentation.

2. National Natural Science Foundation of China Projects: Study on the mechanism for light regulation of polysaccharides biosynthesis in Nostoc flagelliforme.


Committee Member
1. Chinese Institute of Food Science and Technology
2. Chinese Society for Microbiology

3. Tianjin Society of Food Science


Publications
1.Shi-gang Shen, Shi-ru Jia, Yi-kai Wu, Rong-rong Yan, Ya-Hui Lin, Dong-xue Zhao, Pei-pei Han*. Effect of culture conditions on the physicochemical properties and antioxidant activities of polysaccharides from Nostoc flagelliforme. Carbohydrate Polymers, 2018, 198: 426-433
2.Shi-gang Shen, Rong-jun Guo, Rong-rong Yan, Yi-kai Wu, Dong-xue Zhao, Ya-hui Lin, He-xin Lv, Shi-ru Jia*, Pei-pei Han*. Comparative proteomic analysis of Nostoc flagelliforme reveals the difference in adaptive mechanism in response to different ultraviolet-B radiation treatments. Molecular Biology Reports, 2018, accept
3.Shi-gang Shen, Shi-ru Jia, Rong-rong Yan, Yi-kai Wu, Hui-yan Wang, Ya-hui Lin, Dong-xue Zhao, Zhi-lei Tan, He-xin Lv and Pei-pei Han*. The physiological responses of terrestrial cyanobacterium Nostoc flagelliforme to different intensities of ultraviolet-B radiation. RSC Advances, 2018, 8, 21065-21074
4.Pei-pei Han*, Rong-jun Guo, Shi-gang Shen, Rong-rong Yan, Yi-kai Wu, Shun-yu Yao, Hui-yan Wang, Shi-ru Jia*. Proteomic profiling of Nostoc flagelliforme reveals the common mechanism in promoting polysaccharide production by different light qualities. Biochemical Engineering Journal 132 (2018) 68–78.
5.Pei-pei Han, Shi-gang Shen, Rong-jun Guo, Shun-yu Yao, Ying Sun, Zhi-lei Tan, Shi-ru Jia*. The regulation of photosynthetic pigments in terrestrial Nostoc flagelliforme in response to different light colors. Algal Research 25 (2017) 128–135 
6.Pei-pei Han* Shun-yu Yao, Rong-jun Guo, Rong-rong Yan, Yi-kai Wu, Shi-gang Shen, Shi-ru Jia*. Influence of culture conditions on extracellular polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Nostoc flagelliforme. RSC Advances, 2017, 7, 45075-45084
7.Pei-pei Han*, Shun-yu Yao, Rong-jun Guo, Shi-gang Shen, Rong-rong Yan, Zhi-lei Tan, Shi-ru Jia*. The relationship between monosaccharide composition of extracellular polysaccharide and activities of related enzymes in Nostoc flagelliforme under different culture conditions. Carbohydrate Polymers 174 (2017) 111–119
8.Pei-pei Han, Shi-gang Shen, Hui-Yan Wang, Shun-yu Yao, Zhi-lei Tan,  Cheng Zhong, Shi-ru Jia*. Applying the strategy of light environment control to improve the biomass and polysaccharide production of Nostoc flagelliforme. Journal of Applied Phycology,2017, 29(1):55-65
9.Pei-pei Han, Shi-gang Shen, Hui-Yan Wang, Ying Sun, Yu-jie Dai, Shi-ru Jia*. Comparative metabolomic analysis of the effects of light quality on polysaccharide production of cyanobacterium Nostoc flagelliforme. Algal Research-Biomass Biofuels and Bioproducts, 2015, 9: 143-150. 
10.Pei-pei Han, Shi-gang Shen, Shi-ru Jia, Hui-yan Wang, Cheng Zhong, Zhi-lei Tan, He-xin Lv. Comparison of bacterial community structures of terrestrial cyanobacterium Nostoc flagelliforme in three different regions of China using PCR-DGGE analysis. World Journal of Microbiology and Biotechnology, 2015, 31(7):1061-1069.
11.Pei-pei Han, Ying Sun, Shi-ru Jia*, Cheng Zhong, Zhi-lei Tan. Effects of light wavelengths on extracellular and capsular polysaccharide production by Nostoc flagelliforme. Carbohydrate Polymers, 2014, 105: 145–151.
12.Pei-pei Han, Ying Sun, Xiao-ying Wu, Ying-jin Yuan, Yu-jie Dai, Shi-ru Jia*. Emulsifying, Flocculating, and Physicochemical Properties of Exopolysaccharide Produced by Cyanobacterium Nostoc flagelliforme. Applied Biochemistry and Biotechnology, 2014,  172(1): 36-49. 
13.Pei-pei Han, Shi-ru Jia*, Ying Sun, Zhi-lei Tan, Cheng Zhong, Yu-jie Dai, Ning Tan, Shi-gang Shen. Metabolomic approach to optimizing and evaluating antibiotic treatment in the axenic culture of cyanobacterium Nostoc flagelliforme. World Journal of Microbiology & Biotechnology 2014, 30 (9): 2407-2418. 
14.Pei-pei Han, Ting-xiang Ye, Bin Qiao, Ying-jin Yuan*. Taxoids profiling of suspension Taxus chinensis var. mairei cells in response to shear stress. Biochemical Engineering Journal. 2013, 77: 66-73. 
15.Pei-Pei Han and Ying-Jin Yuan*. Lipidomic analysis reveals activation of phospholipid signaling in mechanotransduction of Taxus cuspidata cells in response to shear stress. FASEB Journal. 2009, 23: 623-630. 
16.Pei-Pei Han and Ying-Jin Yuan*. Metabolic profiling as a tool for understanding defense response of Taxus cuspidata cells to shear stress. Biotechnology Progress. 2009, 25: 1244-1253. 
17.Pei-pei Han, Jian Zhou and Ying-jin Yuan*. Analysis of phospholipids, sterols, and fatty acids in Taxus chinensis var. mairei cells in response to shear stress. Biotechnology and Applied Biochemistry.2009, 54: 105–112. 
18.Tao Bo, Pei-Pei Han, Qin-Zhi Su, Ping Fu, Feng-Zhu Guo, Zuo-Xing Zheng, Zhi-Lei Tan, Cheng Zhong, Shi-Ru Jia*, Antimicrobial epsilon-poly-L-lysine induced changes in cell membrane compositions and properties of Saccharomyces cerevisiae, Food Control, 2016, 61:123-134.
19.Tao Bo, Miao Liu, Cheng Zhong, Qian Zhang, Qin-zhi Su, Zhi-lei Tan, Pei-pei Han, Shiru Jia. Metabolomic Analysis of Antimicrobial Mechanisms of epsilon-Poly-L-lysine on Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 2014, 62(19): 4454-4465.
20.Cheng Zhong, Gui-Cai Zhang, Miao Liu, Xin-Tong Zheng, Pei-Pei Han, Shi-Ru Jia*, Metabolic flux analysis of Gluconacetobacter xylinus for bacterial cellulose production, Applied Microbiology and Biotechnology, 2013, 97:6189-6199 
21.Zhen Ding, Shiru Jia, Pei-pei Han, Nannan Yuan, Ning Tan. Effects of carbon sources on growth and extracellular polysaccharide production of Nostoc flagelliforme under heterotrophic high-cell-density fed-batch cultures. Journal of Applied Phycology, 2013, 25(4): 1017-1021
22.Cheng Zhong, Rui Wang, Zhao Zhou, Shi-Ru Jia*, Zhi-Lei Tan, Pei-Pei Han, Functional properties of protein isolates from Caragana Korshinskii Kom. extracted by three different methods, Journal of Agricultural and Food Chemistry, 2012, 60: 10337-10342 

Contact me
Office: 29# 13th Street, Tianjin Economic Developing Area, Tianjin300457
Tel: 86-022-60602822
Fax: 86-022-60602298
Email: pphan@tust.edu.cn

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