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Lectures

Dr. Qing Zhao, lecturer, School of bioengineering, Tianjin University of Science and Technology

Primary Course:

Undergraduate programme 《Molecular Biology》


Teaching Achievement:
Excellent instructor of the third microbiology art competition of Tianjin University of Science and Technology
Instructor of the silver award for college students' Business Plan Competition in Tianjin, 2018
Instructor of the third prize for “i Chuang Da Ren” college students' Business Plan Competition in Tianjin, 2018

Instructor of the gold award for college students' Business Plan Competition of Tianjin University of Science and Technology, 2018


Research Interest:
Discovery, modification, preparation and application of functional proteins
Research and application of industrial enzyme

Research Projects:
1. Foundation of Tianjin Engineering Research Center of Safety Control Technology in Food Processing,2018-2019,project principals

2. Ph.D. Programs Foundation of Ministry of Education of China,2015-2017,project principals


Publications:
1. Tian Zhao, Zhipeng Li, Zhouliang Guo, Ali Wang, Zhenxing Liu, Qing Zhao, Yuyin Li, McKenzie EA, Aipo Diao*, Functional recombinant human Legumain protein expression in Pichia pastoris to enable screening for Legumain small molecule inhibitors, Protein Expr Purif., 2018, 150: 12-16.
2. Qing Zhao, Weiyan Zuo, Shangrong Zhang, Yongqiang Zhang, Chuanyong Li, Shu Jie Li*, Proton pump inhibitors have pH‑dependent effects on the thermostability of the  carboxyl‑terminal domain of voltage‑gated proton channel Hv1, Eur Biophys J, 2018, 47(3):237-247. doi: 10.1007/s00249-017-1253-3.
3. Xudong Wang, Wang Xi, Qing Zhao, Shangrong Zhang , Jiwei Qin, Jili Lv, Yongzhe Che, Weiyan Zuo, Shu Jie Li*, The Voltage-gated Proton Channel Hv1 Is Required for Insulin Secretion in Pancreatic β Cells, BioRxiv, 2017, doi: https://doi.org/10.1101/097816
4. Qing Zhao1, Xudong Wang1, Wang Xi, Shangrong Zhang, Jiwei Qin, Jili Lv, Yongzhe Che, Weiyan Zuo, Shu Jie Li*, Deficiency of Voltage-gated Proton Channel Hv1 Leads to hypoinsulinaemia, hyperglycemia and glucose intolerance in mice, BioRxiv, 2017, doi: http://dx.doi.org/10.1101/097816.
5. Qing Zhao, Yongzhe Che, Qiang Li, Shangrong Zhang, Ying-Tang Gao, Yifan Wang, Xudong Wang, Wang Xi, Weiyan Zuo, Shu Jie Li*, The voltage-gated proton channel Hv1 is expressed in pancreatic islet β-cells and regulates insulin secretion, Biochem. Biophys. Res. Commun., 2015, doi: 10.1016/j.bbrc.2015.11.027.
6. Qing Zhao, Chuanyong Li, Shu Jie Li#, The pH-sensitive structure of the C-terminal domain of voltage-gated proton channel and the thermodynamic characteristics of Zn2+ binding to this domain, Biochem. Biophys. Res. Commun., 2015, doi: 10.1016/j.bbrc.2014.11.060.
7. Qing Zhao, Yongqiang Zhang, Shu Jie Li*, Interaction of dievalent ions with human voltage-gated p,roton channel Hv1, Biometals, 2014, doi: 10.1007/s10534-014-9751-6.
8. Dalong Zhang, Rui Zhang, Jie Zhang, Liying Chen, Chunxia Zhao, Wenyue Dong, Qing Zhao, Qiaqing Wu, Dunming Zhu*, Engineering a hydroxysteroid dehydrogenase to improve its soluble expreesion for the asymmetric reduction of cortistone to 11 beta-hydrocortisone, Appl. Mocrobiol. Biotechnol., 2014, doi: 10.1007/s00253-014-5967-1.
9. Xiangtao Liu, Qing Zhao, Jie Ren, Wenyue Dong, Qiaqing Wu∗, Dunming Zhu*, N-terminal truncation of a maleate cis–trans isomerase from Rhodococcus jostii RHA1 results in a highly active enzyme for the biocatalytic production of fumaric acid, J. Mol. Catal. B: Enzym., 2013, doi: 10.1016/j.molcatb.2013.04.002
10. Yongqiang Zhang, Honghua Deng, Qing Zhao, Shu Jie Li*, Interaction of Presequence with human translocase of inner membrane of mitochondria Tim23, Biochem. Biophys. Res. Commun., 2013, doi: 10.1016/j.bbrc.2013.06.070.
11. Yongqiang Zhang, Honghua Deng, Qing Zhao, Shu Jie Li*, Interaction of Presequence with Human translocase of the Inner Membrane of Mitochondria Tim50, J. Phys. Chem. B, 2012, doi: 10.1021/jp2108279.
12. Yongqiang Zhang, Yun Xu, Qing Zhao, Zhina Ji, Honghua Deng, Shu Jie Li*, The structural characteristics of human preprotein translocase of the inner mitochondrial membrane Tim23: implications for its physiological activities, Protein Expr. Purif., 2012, doi: 10.1016/j.pep.2012.01.009.
13. Yongqiang Zhang, Yun Xu, Qing Zhao, Zhina Ji, Qiang Li, Shu Jie Li*, Expression and structural characterization of human translocase of inner membrane of mitochondria Tim50, Protein Expr. Purif., 2011, doi: 10.1016/j.pep.2011.06.012.
14. Yifan Wang, Shu Jie Li*, Juncheng Pan, Yongzhe Che, Jian Yin, Qing Zhao, Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis, Biochem. Biophys. Res. Commun., 2011, doi: 10.1016/j.bbrc.2011.07.102.
15. Shu Jie Li *, Qing Zhao, Qiangjun Zhou, Hideaki Unno, Yujia Zhai, and Fei Sun, The role and structure of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1, J. Biol. Chem., 2010, doi: 10.1074/jbc.M109.040360. 
16. Shu Jie Li*, Qing Zhao, Qiangjun Zhou and Yujia Zhai, Expression, purification, crystallization and preliminary crystallographic study of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1, Acta Crystallogr. 2009, doi: 10.1107/S1744309109003777.

Contact information
Address:Room 107, Building No.2, Tianjin University of Science & Technology
Technological Development Area (TEDA), Tianjin,
Postal Code:300457
Telephone:022-60602948
Email:zhao_qing@tust.edu.cn
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