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Professors

Xuegang Luo, Ph.D, Professor, Vice Dean of College of Biotechnology
Director of China Biotech Fermentation Industry Association Probiotic Products Branch; Director of Tianjin Food Society; Member of Chinese Pharmacological Society; Member of China Society for Microbiology; Second Level Candidate of Tianjin 131 Innovative Talents Training Program.


Teaching duties
Undergraduate courses:  
Postgraduates courses:


Education Research
[1] Tianjin University of Science and Technology Educational and Teaching Reform Project: Establishment of a New Bilingual Teaching System of Pharmacology for Pharmaceutical Engineering Specialty. PI.
[2] Luo XG, Mu A, Zhao WW, et al. Establishment of a Reformed Chinese-English Bilingual Teaching System of Pharmacology in Tianjin University of Science and Technology, China. Indian Journal of Pharmaceutical Education and Research. 2015, 49(1): 26-30. (SCI)
[3] Xuegang Luo. Pharmacology (Bilingual) (2nd Edn). Huazhong University of Science and Technology Press. 2016. ISBN 978-7-5609-9002-6.
[4] Rong Yu, Gang Guo, Xuegang Luo et al. Biopharmaceutics. Science Press. 2017. SBN 978-7-03-048780-3.
[5] Xuegang Luo, Tongcun Zhang, Nan Wang, Hua Sun, Yuou Teng, Hongpeng He. Construction and Practice of Bilingual Teaching System for Pharmacology of Pharmaceutical Engineering Specialty. First Prize of Tianjin University of Science and Technology Teaching Achievement Award. 2018.
[6] Construction and Practice of Biopharmaceutical Innovation Talents Training System for New Engineering Construction. First Prize of Tianjin University of Science and Technology Teaching Achievement Award. 2018. (Ranked second)
[7] Construction and Practice of Biopharmaceutical Innovation Talents Training System for New Engineering Construction. First Prize of Tianjin teaching achievement award. 2018. (Ranked third)
[11] First Prize of the 6th Young Teachers' Teaching Basic Skills Competition of Tianjin University of Science and Technology.2010.


Research Interests
[1] Microbiota function mechanism and probiotic products;
[2] Transcriptional regulatory mechanism of serious diseases such as cardiovascular and tumor; Microbial synthesis of function factor and biochemical drugs;


Fundings
[1] National Key R&D Program of China: Health function of probiotics and mechanism of food nutrient metabolism based on intestinal microbiology, "Study on regulatory resistance mechanism of probiotics and function genes related to production characters". Sub-PI.
[2] National Natural Science Foundation of China (NSFC) grant: Study on mechanism of SMYD3 in breast cancer TGF-β1 induction of EMT process. PI.
[3] Tianjin Natural Science Foundation Grant: Study on the regulatory function of HMG-CoA reductase and antihyperlipidemia effect of Lactobacillus plantarum CGMCC8198. PI.
[4] Tianjin University of Science and Technology Young Teacher Innovation Fund: The transcriptional repression mechanism of HMGCR in Lactobacillus plantarum CGMCC8198. PI.
[5] National Natural Science Foundation of China (NSFC) grant: Study on interaction between MRTF-A and SMYD3 and transcription activation mechanism of related invasive suppressor gene in tumor progression. PI.
[6] Tianjin Science and Technology Development Fund: Synergistic transcriptional activation of CYR61 by Myocardin-associated transcription factor A and SMYD3. PI.
[7] National Natural Science Foundation of China (NSFC) Grant: Feedback regulation between estrogen receptor alpha and SMYD3 and its effect on estrogen metabolism in breast cells. PI.


Selected Publications
[1]Li ZY, Feng CX, Luo XG*, et al. Revealing the influence of microbiota on the quality of Pu-erh tea during fermentation process by shotgun metagenomic and metabolomic analysis. Food Microbiology, 2018, 76: 405-410. (*Corresponding author )
[2]Miao Z, Li Q, Zhao J, Wang P, Wang L, He HP, Wang N, Zhou H, Zhang TC, Luo XG*. Stable expression of infliximab in CRISPR/Cas9-mediated BAK1-deficient CHO cells. Biotechnol Lett. 2018, 40(8): 1209-1218. (*Corresponding author ) 
[3]Li Q, Miao Z, Luo XG*, Zhao J, Song YJ, Li ZY, Zhou H, Zhang TC, Mao LS. Expression and bioactivity analysis of TNF30, a TNFα nanobody, in Escherichia coli. Biotechnology & Biotechnological Equipment, 2018, June, online. (*Corresponding author ) 
[4]Dong QQ, Wang QT, Wang L, Jiang YX, Liu ML, Hu HJ, Liu Y, Zhou H, He HP, Zhang TC,  Luo XG*. SMYD3-associated Pathway is Involved in the Anti-tumor Effects of Sulforaphane on Gastric Carcinoma Cells. Food Science and Biotechnology, 2018, Mar, online. (*Corresponding author )
[5]Li XM, Luo XG*, He JF, Wang N, Zhou H, Yang PL, Zhang TC*. Induction of apoptosis in human cervical carcinoma HeLa cells by activity compounds from Hypericum ascyron L.. Oncology letters, 2018, 15: 3944-3950. (IF2017=1.664) (*Corresponding author )
[6]Wang L, Wang QT, Liu YP, Dong QQ, Hu HJ, Miao Z, Li S, Liu Y, Zhou H, Zhang TC, Ma WJ, Luo XG*. ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells. Journal of Gastric Cancer, 2017, 17(4): 295-305. (*Corresponding author)
[7]Yang BC, Zhang C, Wang C, Zhou H, Li ZY, Song YJ, Zhang TC, Luo XG*. Soluble expression and purification of heparinase I in Escherichia coli using a hexahistidine-tagged small ubiquitin-like modifier as a fusion partner. Biotechnology & Biotechnological Equipment, 2017, 31(5): 1040-1045. (*Corresponding author)
[8]Zhang CJ, Pan LJ, Lu WH, Zhou H, Wang N, Zhang TC, Luo XG*. Lactobacillus Plantarum CGMCC8198-Fermented Milk Inhibits Melanogenesis in B16F10 Melanoma Cells. Food Science and Technology Research, 2017, 23(5): 669-678. (*Corresponding author)
[9]Chen DJ, Yan LH, Zhang CJ, Si CL, Li ZY, Song YJ, Zhou H, Zhang TC, Luo XG*. Bioconversion of conjugated linoleic acid by Lactobacillus plantarum CGMCC8198 supplemented with Acer truncatum Bunge seeds oil. Food Science and Biotechnology, 2017, 26(6): 1595-1611. (*C orresponding author)
[10]Chen DJ, Liu L, Luo XG*, et al. Effect of SMYD3 on MicroRNAs Expression Profile in MCF-7 Breast Cancer Cells. Oncology letters, 2017, 14: 1831-1840. (*Corresponding author)
[11]Dong QQ, Hu HJ, Luo XG*, et al. Complete Genome Sequence of Lactobacillus plantarum CGMCC8198. Genome Announcements, 2017, 5(6). Pii: e01559-16. (*Corresponding author)
[12]Sun H, Liu Y, Zhang C, Luo X*, Jiang X*. Peptidic β-sheets induce Congo red-derived fluorescence to improve the sensitivity of HIV-1 p24 detection. Anal. Methods, 2017, 9: 1185-1189. (*Corresponding author)
[13]Luo XG, Ma DY, Wang Y, et al. Fusion with pep-1, a cell-penetrating peptide, enhances the transmembrane ability of human epidermal growth factor. Biosci Biotech Bioch, 2016, 80(3): 584-590. 
[14]Luo XG, Zhang CL, Zhao WW, et al. Histone methyltransferase SMYD3 promotes MRTF-A - mediated transactivation of MYL9 and migration of MCF-7 breast cancer cells. Cancer Lett, 2014, 344(1): 129-137. 
[15]Hu HJ, Luo XG*, Dong QQ, Mu A, Shi GL, Wang QT, Chen XY, Zhou H, Zhang TC, Pan LW*. Ethanol extract of Zhongtian hawthorn lowers serum cholesterol in mice by inhibiting transcription of 3-hydroxy-3-methylglutaryl-CoA reductase via nuclear factor-kappa B signal pathway. Experimental Biology and Medicine, 2016, 241(6): 667-674. (*Corresponding author)
[16]Li XM, Luo XG*, Li K, Wang N, Hua EB, Zhang Y, Zhang TC*. Difference in protective effects of three structurally similar flavonoid glycosides from Hypericum ascyron against H2O2-induced injury in H9c2 cardiomyoblasts. Mol Med Rep, 2015, 12: 5423-5428. (*Corresponding author)
[17]Li XM, Luo XG*, Si CL, Wang N, Zhou H, He JF, Zhang TC*. Antibacterial active compounds from Hypericum ascyron L. induce bacterial cell death through apoptosis pathway. Eur J Med Chem. 2015, 96: 436-444. (*Corresponding author)
[18]Li XM, Luo XG*, Wang N, Zhou H, Si CL, Li K, Ma N, Zhang TC*. The extract of Hypericum ascyron L. induces bacterial cell death through apoptosis pathway. J Ethnopharmacol. 2015, 166: 205-210. (*Corresponding author) 
[19]Li XM, Luo XG*, Zhang CZ, Wang N, Zhang T*. Quality evaluation of Hypericum ascyron extract by two-dimensional high-performance liquid chromatography coupled with the colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. J Sep Sci. 2015, 38(4): 576-584. (*Corresponding author) 
[20]Li XM, Luo XG*, Ma N, Li K, Li W, Ma DY, Zhang TC*. Quality and antitumour activity evaluation of extract of Hypericum ascyron. Biomed Chromatogr. 2015, 29(1): 47-52. (*Co-first author with student, corresponding author) 
[21]Gu XC, Luo XG*, Wang CX, Ma DY, Wang Y, He YY, Li W, Zhou H, Zhang TC*. Cloning and analysis of Bile Salt Hydrolase Genes from Lactobacillus plantarum CGMCC No. 8198. Biotechnol Lett, 2014, 36(5): 975-983. (*Corresponding author)
[22]Zhang CL, Luo XG*, Liu L, Guo S, Zhao WW, Mu A, Zhou H, Wang N, Zhang TC*. Myocardin-related transcription factor A is upregulated by 17β-estradiol and promotes migration of MCF-7 breast cancer cells via transactivation of MYL9 and CYR61. Acta Bioch Bioph Sin, 2013, 45(11): 921-927. (*Corresponding author) 
[23]Liu ZP, Luo XG*, Liu L, Zhao W, Guo S, Guo Y, Wang N, He H, Liao X, Ma W, Zhou H, Zhang T*. Histone acetyltransferase p300 promotes MKL1- mediated transactivation of COMT gene and accelerates the metabolism of 17β-estradiol. Acta Bioch Bioph Sin, 2013, 45(12): 1002-1010. (*Corresponding author)


Authorized patents in recent years
[1] Antioxidative and antihypertensive activities of lactic acid bacteria Fermented Dairy Products production method. Patent No.: ZL201110140908.9
[2] Construction and High-rate Expression of Hst 5 engineered strain. Patent No.: ZL201210227517.5
[3] Selective improvement property of bile-tolerance resistant strain and bile salt hydrolase gene. Patent No.: ZL201310491340.4
[4] The effects of Lactobacillus plantarum on reducing blood lipid and weight reduction. Patent No.: ZL201310518617.8
[5] Application of hypericum ascyron extract in antitumor effects and tumor growth inhibition drugs. Patent No.: ZL201310240009.5


Contact
Address: College of Biotechnology, Tianjin University of Science and Technology No. 29, 13th Street, Tianjin Economic-Technological Development Area (TEDA), Tianjin, P.R. China.
Postal code: 300457
Office Telephone: 022-60601104
Email:luoxuegang@tust.edu.cn

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