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讲师


孟璇,博士,yh1187银河网站,讲师。2020年获天津大学博士学位。


主讲课程:

本科生:《有机合成路线设计》


科研领域及方向

[1] 应答响应型药物递送系统

致力于肿瘤微环境调控的智能纳米药物递送系统,包括高分子纳米胶束、无机-有机杂化载体、脂质体、水凝胶等。

[2] 新型生物材料的研究

通过药学、化学、生物学与纳米医学等手段,研究新型纳米材料在生物领域的应用,用于疾病防治与诊疗。


科研项目情况

[1] 973计划:分子基功能碳材料新型拓扑结构的基础与前沿研究,2015-2019;参与。

[2] 国家自然科学基金项目:应答型纳米载体增敏ACSL4缺失肿瘤细胞的程序性铁死亡研究,2020-2023;参与。


主要学术成果

先后发表SCI高水平论文十余篇,累计影响因子>70。发表的主要学术论文有:

1. Meng X, Deng J, Liu F, Guo T, Liu M, Dai P, Fan A, Wang Z, and Zhao Y. Triggered all-active metal organic framework: Ferroptosismachinery contributes to the apoptotic photodynamic antitumor therapy. NanoLetters, 2019, 19(11): 7866-7876. (SCI 1, Top journal, IF: 12.279)

2. Meng X, Gao M, Deng J, Lu D, Fan A, Ding D, Kong D, Wang Z, and Zhao Y.Self-immolative micellar drug delivery: The linker matters. Nano Research,2018, 11(12): 6177-6189. (SCI 1, Top journal, IF: 8.515)

3. Gao M#,Meng X#, Guo X, Zhu J, Fan A, Wang Z, and Zhao Y.All-active antitumor micelles via triggered lipid peroxidation. Journal of ControlledRelease, 2018, 286: 381-393. (Co-first author; SCI 1, Top journal,IF: 7.901)

4. Li J#, Meng X#, Deng J,Lu D, Zhang X, Chen Y, Zhu J, Fan A, Ding D, Kong D, Wang Z, and Zhao Y. Multifunctionalmicelles dually responsive to hypoxia and singlet oxygen: enhanced photodynamictherapy via interactively triggered photosensitizer delivery. ACS Applied Materials& Interfaces, 2018, 10(20): 17117-17128. (Co-first author; SCI 1,Top journal, IF: 8.456)

5. Zhang S#, Meng X#, Wang Z,Fan A, Wang G, Zhao Y, and Tang Y. Engineering hot-melt extruded solid dispersionfor controlled release of hydrophilic drugs. EuropeanJournal of Pharmaceutical Sciences, 2017, 100: 109-115. (Co-first author; SCI 2,IF: 3.532)

6. An Y, Zhu J, Liu F, Deng J, Meng X,Liu G, Wu H, Fan A, Wang Z and Zhao Y. Boosting the ferroptotic antitumor efficacyvia site-specific amplification of tailored lipid peroxidation. ACS Applied Materials& Interfaces, 2019, 11(33): 29655-29666.

7. Yan Q, Guo X, Huang X, Meng X,Liu F, Dai P, Wang Z, and Zhao Y. Gated mesoporous silica nanocarriers for hypoxia-responsivecargo release. ACS Applied Materials & Interfaces, 2019, 11(27):24377-24385.

8. Chen C, Zhao J, Gao M, Meng X,Fan A, Wang Z, and Zhao Y. Photo-triggered micelles: simultaneous activationand release of microtubule inhibitors for on-demand chemotherapy. Biomaterials Science,2018, 6(3): 511-518.

9. Xin K, Li M, Lu D, Meng X, DengJ, Kong D, Ding D, Wang Z, and Zhao Y. Bioinspired coordination micellesintegrating high stability, triggered cargo release, and magnetic resonanceimaging. ACS Applied Materials & Interfaces, 2017, 9(1): 80-91.

10. Li M, Gao M, Fu Y, Chen C, Meng X,Fan A, Kong D, Wang Z, and Zhao Y. Acetal-linked polymeric prodrug micelles forenhanced curcumin delivery. Colloids and Surfaces B: Biointerfaces,2016, 140: 11-18.


联系方式

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真:022-60602298

Emailmengxuan@tust.edu.cn

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